Estrogen-regulated expression of cyp19a1a and cyp19a1b genes in swim-up fry of Labeo rohita

Gupta, Shreyasi; Moulik, Sujata Roy; Pal, Puja; Majumder, Suravi; Das, Saswati; Guha, Payel; Juin, Subir Kumar; Panigrahi, A. K.; Mukherjee, Dilip

doi:10.1016/j.ygcen.2017.06.026

Cited by 18 publications

(6 citation statements)

References 63 publications

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“…These notably include aromatase cyp19a1, Estrogen receptor beta-1, and Epidermal growth factor receptor. Of note, cyp19a2 is not detected at all in our transcriptome data, consistent with only cyp19a1 being a brain aromatase in fish [52]. Increased expression in hatching females under EE2 was rare (8 genes, among them another copy of the Epidermal growth factor receptor).…”

Section: Resultssupporting

confidence: 76%

Sex-specific changes in gene expression in response to estrogen pollution around the onset of sex differentiation in grayling (Salmonidae)

et al. 2019

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The synthetic 17α-ethinylestradiol (EE2) is a common estrogenic pollutant that has been suspected to affect the demography of river-dwelling salmonids. One possibility is that exposure to EE2 tips the balance during initial steps of sex differentiation, so that male genotypes show female-specific gene expression and gonad formation. Here we study EE2 effects on gene expression around the onset of sex differentiation in a population of European grayling ( Thymallus thymallus ) that suffers from sex ratio distortions. We exposed singly-raised embryos to one dose of 1 ng/L EE2, studied gene expression 10 days before hatching, at the day of hatching, and around the end of the yolk-sac stage, and related it to genetic sex (sdY genotype). We found that exposure to EE2 affects expression of a large number of genes, especially around hatching. These effects were strongly sex-dependent. We then raised fish for several months after hatching and found no evidence of sex reversal in the EE2-exposed fish. We conclude that ecologically relevant (i.e. low) levels of EE2 pollution do not cause sex reversal by simply tipping the balance at early stages of sex differentiation, but that they interfere with sex-specific gene expression. Electronic supplementary material The online version of this article (10.1186/s12864-019-5955-z) contains supplementary material, which is available to authorized users.

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Section: Resultssupporting

confidence: 76%

Sex-specific changes in gene expression in response to estrogen pollution around the onset of sex differentiation in grayling (Salmonidae)

et al. 2019

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“…For example, a TiO 2 /ZnO nanocomposite with a Ti:Zn molar ratio of 1 : 0.3 was successfully applied to the photocatalytic degradation of steroid hormones, such as 17 α -ethinylestradiol (EE2) and 17 β -estradiol (E2), at low initial concentrations (from 50 μ g/L to 10 mg/L) [130]. Continuous exposure to these hormones, even at low concentrations, can disrupt the endocrine system [131], inducing serious adverse effects on human health such as infertility and increased incidence of breast, ovarian, and testicular cancer [132]. The obtained TiO 2 /ZnO photocatalyst has showed approximately 25% and 10% mineralization for E2 and EE2, respectively, after 240 min of visible-light irradiation.…”

Section: Discussionmentioning

confidence: 99%

Heavy Metal Removal from Aqueous Effluents by TiO₂ and ZnO Nanomaterials

Lissarrague

Alshehri

Alsalhi

et al. 2023

Adsorption Science & Technology

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The presence of heavy metals in wastewater, such as Ni, Pb, Cd, V, Cr, and Cu, is a serious environmental problem. This kind of inorganic pollutant is not biodegradable for several years, and its harmful effect is cumulative. Recently, semiconductor nanomaterials based on metal oxides have gained interest due to their efficiency in the removal of heavy metals from contaminated water, by inducing photocatalytic ion reduction when they absorb light of the appropriate wavelength. The most commonly applied semiconductor oxides for these purposes are titanium oxide (TiO2), zinc oxide (ZnO), and binary nanomaterials composed of both types of oxides. The main purpose of this work is to critically analyse the existent literature concerning this topic focusing specially in the most important factors affecting the adsorption or photocatalytic capacities of this type of nanomaterials. In particular, photocatalytic activity is altered by various factors, such as proportion of polymorphs, synthesis method, surface area, concentration of defects and particle size, among others. After a survey of the actual literature, it was found that, although these metal oxides have low absorption capacity for visible light, it is possible to obtain an acceptable heavy metal reduction performance by sensitization with dyes, doping with metallic or nonmetallic atoms, introduction of defects, or the coupling of two or more semiconductors.

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“…The Cyp19a1b gene is commonly referred to as aromatase B or brain aromatase ( Mouriec et al, 2009 ), which has estrogen response elements (EREs) in its promoter where ERα and ERβ can bind and control expression ( Menuet et al, 2005 ; Le Page et al, 2006 , 2008 ). In addition, studies in Indian major carp showed that a 6-d E2 treatment significantly increased Cyp19a1b expression in the brain, which was suppressed by aromatase inhibitors ( Gupta et al, 2017 ). The effects of estrogen on the Cyp19a1b gene might be cell-specific and have only been reported in radial glial cells or astrocytes ( Menuet et al, 2005 ; Le Page et al, 2006 , 2008 ).…”

Section: Discussionmentioning

confidence: 99%

Ovarian Hormones Regulate Nicotine Consumption and Accumbens Glutamatergic Plasticity in Female Rats

Maher

Kipp²,

Leyrer‐Jackson³

et al. 2022

eNeuro

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Women report greater cigarette cravings during the menstrual cycle phase with higher circulating levels of 17β-estradiol (E2), which is metabolized to estrone (E1). Both E2 and E1 bind to estrogen receptors (ERs), which have been highly studied in the breast, uterus, and ovary. Recent studies have found that ERs are also located on GABAergic medium spiny neurons (MSNs) within the nucleus accumbens core (NAcore). Glutamatergic plasticity in NAcore MSNs is altered following nicotine use; however, it is unknown whether estrogens impact this neurobiological consequence. To test the effect of estrogen on nicotine use, we ovariectomized (OVX) female rats that then underwent nicotine self-administration acquisition and compared them to ovary-intact (sham) rats. The OVX animals then received either sesame oil (vehicle), E2, or E1+E2 supplementation for 4 or 20 d before nicotine sessions. While both ovary-intact and OVX females readily discriminated levers, OVX females consumed less nicotine than sham females. Further, neither E2 nor E1+E2 increased nicotine consumption back to sham levels following OVX, regardless of the duration of the treatment. OVX also rendered NAcore MSNs in a potentiated state following nicotine self-administration, which was reversed by 4 d of systemic E2 treatment. Finally, we found that E2 and E1+E2 increased ERα mRNA in the NAcore, but nicotine suppressed this regardless of hormone treatment. Together, these results show that estrogens regulate nicotine neurobiology, but additional factors may be required to restore nicotine consumption to ovary-intact levels.

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Estrogen-regulated expression of cyp19a1a and cyp19a1b genes in swim-up fry of Labeo rohita

Cited by 18 publications

References 63 publications

Sex-specific changes in gene expression in response to estrogen pollution around the onset of sex differentiation in grayling (Salmonidae)

Sex-specific changes in gene expression in response to estrogen pollution around the onset of sex differentiation in grayling (Salmonidae)

Heavy Metal Removal from Aqueous Effluents by TiO₂ and ZnO Nanomaterials

Ovarian Hormones Regulate Nicotine Consumption and Accumbens Glutamatergic Plasticity in Female Rats

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Estrogen-regulated expression of cyp19a1a and cyp19a1b genes in swim-up fry of Labeo rohita

Cited by 18 publications

References 63 publications

Sex-specific changes in gene expression in response to estrogen pollution around the onset of sex differentiation in grayling (Salmonidae)

Sex-specific changes in gene expression in response to estrogen pollution around the onset of sex differentiation in grayling (Salmonidae)

Heavy Metal Removal from Aqueous Effluents by TiO2 and ZnO Nanomaterials

Ovarian Hormones Regulate Nicotine Consumption and Accumbens Glutamatergic Plasticity in Female Rats

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Resources

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Heavy Metal Removal from Aqueous Effluents by TiO₂ and ZnO Nanomaterials