Estrogen regulation and ion dependence of taurine uptake by MCF-7 human breast cancer cells

Shennan, D.B.; Thomson, Jean

doi:10.2478/s11658-007-0011-4

Cited by 7 publications

(5 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, taurine concentration seems to be related to estrogen activity in the brain. Indeed, estrogen receptors regulate taurine uptake via the Na þ -dependent taurine transporter (TauT) in MCF-7 human breast cancer cells (Han et al, 2006;Shennan and Thomson, 2007). Both estrogen receptors ERa and ERb are present in the mouse cortex, hippocampus, and striatum, although striatal levels of either messenger RNA or protein are much lower (Küppers and Beyer, 1999;Mitra et al, 2003;Shughrue and Merchenthaler, 2000).…”

Section: Discussionmentioning

confidence: 99%

Longitudinal neurochemical modifications in the aging mouse brain measured in vivo by 1H magnetic resonance spectroscopy

Duarte

Gruetter

2014

Neurobiology of Aging

View full text Add to dashboard Cite

H MRS Brain Metabolism a b s t r a c tAlterations to brain homeostasis during development are reflected in the neurochemical profile determined noninvasively by 1 H magnetic resonance spectroscopy. We determined longitudinal biochemical modifications in the cortex, hippocampus, and striatum of C57BL/6 mice aged between 3 and 24 months . The regional neurochemical profile evolution indicated that aging induces general modifications of neurotransmission processes (reduced GABA and glutamate), primary energy metabolism (altered glucose, alanine, and lactate) and turnover of lipid membranes (modification of choline-containing compounds and phosphorylethanolamine), which are all probably involved in the frequently observed age-related cognitive decline. Interestingly, the neurochemical profile was different in male and female mice, particularly in the levels of taurine that may be under the control of estrogen receptors. These neurochemical profiles constitute the basal concentrations in cortex, hippocampus, and striatum of healthy aging male and female mice.

show abstract

Section: Discussionmentioning

confidence: 99%

Longitudinal neurochemical modifications in the aging mouse brain measured in vivo by 1H magnetic resonance spectroscopy

Duarte

Gruetter

2014

Neurobiology of Aging

View full text Add to dashboard Cite

show abstract

“…An effect of Tat transgene leak also is plausible given that induction of Tat expression induces cortical edema in young Tat-tg mice [46], that Tat likely causes edema in older female Tat-tg mice [15], and that edema triggers cellular taurine loss to counter extracellular hypoosmolality [73]. Because estrogen upregulates taurine transporter activity [76] and reduces taurine efflux in an estrogen receptordependent manner consequent to glutamate excitotoxicity [77], estradiol declines in older female mice also may contribute to the especially low MPFC and striatal taurine levels we found in older female Tattg mice (Fig. 2).…”

Section: Taurinementioning

confidence: 99%

In vivo proton magnetic resonance spectroscopy detection of metabolite abnormalities in aged Tat-transgenic mouse brain

et al. 2021

View full text Add to dashboard Cite

Most individuals living with HIV in the USA are over 45 years old and are vulnerable to the combined effects of HIV and aging. Antiretroviral therapies reduce HIV morbidity and mortality but do not prevent HIV trans-activator of transcription (Tat) protein expression or development of HIV-associated neurocognitive disorder (HAND), which may be caused by Tat. Tattransgenic (Tat-tg) mice are used to study Tat's effects, typically after transgene induction with doxycycline. However, uninduced Tat-tg mice experience transgene leak and model aspects of HAND when aged, including neuroinflammation. We used in vivo 9.4-tesla proton magnetic resonance spectroscopy to compare neurochemistry in aged versus young female and male uninduced Tat-tg mice. Aged Tat-tg mice demonstrated measurable tat mRNA brain expression and had lower medial prefrontal cortex (MPFC) GABA, glutamate, and taurine levels and lower striatal GABA and taurine levels. Females had lower MPFC glutathione and taurine and lower striatal taurine levels. Brain testosterone levels were negatively correlated with age in aged males but not females. Aged mice had cortical abnormalities not previously reported in aged wild-type mice including lower MPFC GABA and taurine levels. As glutathione and taurine levels reflect inflammation and oxidative stress, our data suggest that Tat may exacerbate these processes in aged Tat-tg mice. However, additional studies in controls not expressing Tat are needed to confirm this point and to deconvolve individual effects of age and Tat expression. Sex steroid hormone supplements, which counter climacteric effects, increase taurine levels, and reduce inflammation and oxidative stress, could attenuate some of the brain abnormalities we identified in aged Tat-tg mice.

show abstract

“…In that sense, taurine compromised metastasis in both breast cancer cell lines, independently of the presence of estrogen receptor. Besides, it should be noted that estrogen exerted its significant effect on taurine uptake, through increased expression of TauT transporter in MCF-7 cells (86). It has been reported that Na + -dependent uptake of taurine through TauT transporter was activated by 17β-estradiol and p53 transcription factor, as shown by experiments in MCF-7 cells (87).…”

Section: Beneficial Effect Of Taurine In Various Cancers (In Vitro Anmentioning

confidence: 89%

Role of taurine, its haloamines and its lncRNA TUG1 in both inflammation and cancer progression. On the road to therapeutics? (Review)

Baliou

Kyriakopoulos²,

Spandidos

et al. 2020

Int J Oncol

View full text Add to dashboard Cite

For one century, taurine is considered as an end product of sulfur metabolism. In this review, we discuss the beneficial effect of taurine, its haloamines and taurine upregulated gene 1 (TUG1) long non-coding RNA (lncRNA) in both cancer and inflammation. We outline how taurine or its haloamines (N-Bromotaurine or N-Chlorotaurine) can induce robust and efficient responses against inflammatory diseases, providing insight into their molecular mechanisms. We also provide information about the use of taurine as a therapeutic approach to cancer. Taurine can be combined with other chemotherapeutic drugs, not only mediating durable responses in various malignancies, but also circumventing the limitations met from chemotherapeutic drugs, thus improving the therapeutic outcome. Interestingly, the lncRNA TUG1 is regarded as a promising therapeutic approach, which can overcome acquired resistance of cancer cells to selected strategies. In this regard, we can translate basic knowledge about taurine and its TUG1 lncRNA into potential therapeutic options directed against specific oncogenic signaling targets, thereby bridging the gap between bench and bedside. Contents 1. The role of taurine in inflammation 2. Formation of taurine haloamines 3. Anti-microbial properties of taurine haloamines 4. Anti-inflammatory and anti-oxidant properties of taurine haloamines 5. Therapeutic perspectives and clinical studies 6. Significance of lncRNA TUG1 lncRNA in cancer 7. The association of lncRNA TUG1 and chemoresistance 8. The role of taurine or lncRNA TUG1 as a prognostic marker 9. Conclusions

show abstract

Estrogen regulation and ion dependence of taurine uptake by MCF-7 human breast cancer cells

Cited by 7 publications

References 24 publications

Longitudinal neurochemical modifications in the aging mouse brain measured in vivo by 1H magnetic resonance spectroscopy

Longitudinal neurochemical modifications in the aging mouse brain measured in vivo by 1H magnetic resonance spectroscopy

In vivo proton magnetic resonance spectroscopy detection of metabolite abnormalities in aged Tat-transgenic mouse brain

Role of taurine, its haloamines and its lncRNA TUG1 in both inflammation and cancer progression. On the road to therapeutics? (Review)

Contact Info

Product

Resources

About