Estrogen Regulation of the Expression of Pain Factor NGF in Rat Chondrocytes

Shang, Xiaoqiang; Zhang, Liaoran; Jin, Rilong; Hu, Yang; Tao, Hairong

doi:10.2147/jpr.s297442

Cited by 3 publications

(3 citation statements)

References 46 publications

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“… 52 , 53 Estrogen significantly reduced NGF mRNA and protein expression levels in rat chondrocytes. 54 This is similar to previous studies showing that estrogen reduced NGF levels in rat hippocampus and sympathetic neurons. 55 , 56 Moreover, long-term estrogen replacement decreased TrkA mRNA levels in the DRG, which can alter NGF response.…”

Section: Downregulation Of Trpv1 and P2x3 By Estrogensupporting

confidence: 92%

Estrogen-dependent regulation of transient receptor potential vanilloid 1 (TRPV1) and P2X purinoceptor 3 (P2X3): Implication in burning mouth syndrome

Seol

Chung

2022

Journal of Dental Sciences

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Sex differences in the nervous system have gained recent academic interest. While the prominent differences are observed in mood and anxiety disorders, growing number of evidences also suggest sex difference in pain perception. This review focuses on estrogen as the key molecule underlying such difference, because estrogen plays many functions in the nervous system, including modulation of transient receptor potential vanilloid 1 (TRPV1) and P2X purinoceptor 3 (P2X3), two important nociceptive receptors. Estrogen was shown in various studies to up-regulate TRPV1 expression through two distinct pathways, resulting in pro-nociceptive effect. However, estrogen alleviated pain in other studies, by down-regulating nerve growth factor (NGF)–activated pathways and TRPV1. Estrogen may also attenuate nociception by inhibiting P2X3 receptors and ATP-signaling. Understanding the mechanism underlying the pro- and anti-nociceptive effect of estrogen might be crucial to understand pathophysiology of the burning mouth syndrome (BMS), a common chronic orofacial pain disorder in menopausal women. The involvement of TRPV1 is strongly suspected because of burning sensation. Reduced estrogen level of the BMS patient might have caused increased activity of P2X3 receptors. Interestingly, the increased expression of TRPV1 and P2X3 in oral mucosa of BMS patients was reported. The combinational impact of differential modulation of TRPV1/P2X3 during menopause might be an important contributing factor of etiology of BMS. Understanding the estrogen-dependent regulation of nociceptive receptors may provide a valuable insight toward the peripheral mechanism of sex-difference in pain perception.

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Section: Downregulation Of Trpv1 and P2x3 By Estrogensupporting

confidence: 92%

Estrogen-dependent regulation of transient receptor potential vanilloid 1 (TRPV1) and P2X purinoceptor 3 (P2X3): Implication in burning mouth syndrome

Seol

Chung

2022

Journal of Dental Sciences

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“…High E2 concentration has been linked to increased IL1β stimulated proteoglycan degradation and MMP production in chondrocytes [ 83 ]. Interestingly, E2 has been observed to reduce nerve growth factor (NGF) expression in chondrocytes significantly, even after stimulation by TGFβ1 or IL1β, indicating estrogen can play a role in regulating NGF, which is integral to the development of OA pain, suggesting that E2 is associated with decreased OA pain [ 84 ]. The contradictory results make it difficult to understand the role estrogen plays in cartilage degradation and further demonstrates more research is needed.…”

Section: Protective Effect Of Sex Hormones On Cartilage Degradationmentioning

confidence: 99%

Sex-dependent variation in cartilage adaptation: from degeneration to regeneration

Patel

Chen²,

Katzmeyer

et al. 2023

Biol Sex Differ

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Despite acknowledgement in the scientific community of sex-based differences in cartilage biology, the implications for study design remain unclear, with many studies continuing to arbitrarily assign demographics. Clinically, it has been well-established that males and females differ in cartilage degeneration, and accumulating evidence points to the importance of sex differences in the field of cartilage repair. However, a comprehensive review of the mechanisms behind this trend and the influence of sex on cartilage regeneration has not yet been presented. This paper aims to summarize current findings regarding sex-dependent variation in knee anatomy, sex hormones’ effect on cartilage, and cartilaginous degeneration and regeneration, with a focus on stem cell therapies. Findings suggest that the stem cells themselves, as well as their surrounding microenvironment, contribute to sex-based differences. Accordingly, this paper underscores the contribution of both stem cell donor and recipient sex to sex-related differences in treatment efficacy. Cartilage regeneration is a field that needs more research to optimize strategies for better clinical results; taking sex into account could be a big factor in developing more effective and personalized treatments. The compilation of this information emphasizes the importance of investing further research in sex differences in cartilage biology.

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“…This result suggests that the MEK-ERK signaling pathway may be mediated by the modulatory effects of E2 on NGF. 186 …”

Section: Molecular Mechanisms By Which Estrogen Alleviates Ivd Degene...mentioning

confidence: 99%

Low back pain and osteoarthritis pain: a perspective of estrogen

et al. 2023

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Low back pain (LBP) is the world’s leading cause of disability and is increasing in prevalence more rapidly than any other pain condition. Intervertebral disc (IVD) degeneration and facet joint osteoarthritis (FJOA) are two common causes of LBP, and both occur more frequently in elderly women than in other populations. Moreover, osteoarthritis (OA) and OA pain, regardless of the joint, are experienced by up to twice as many women as men, and this difference is amplified during menopause. Changes in estrogen may be an important contributor to these pain states. Receptors for estrogen have been found within IVD tissue and nearby joints, highlighting the potential roles of estrogen within and surrounding the IVDs and joints. In addition, estrogen supplementation has been shown to be effective at ameliorating IVD degeneration and OA progression, indicating its potential use as a therapeutic agent for people with LBP and OA pain. This review comprehensively examines the relationship between estrogen and these pain conditions by summarizing recent preclinical and clinical findings. The potential molecular mechanisms by which estrogen may relieve LBP associated with IVD degeneration and FJOA and OA pain are discussed.

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Estrogen Regulation of the Expression of Pain Factor NGF in Rat Chondrocytes

Cited by 3 publications

References 46 publications

Estrogen-dependent regulation of transient receptor potential vanilloid 1 (TRPV1) and P2X purinoceptor 3 (P2X3): Implication in burning mouth syndrome

Estrogen-dependent regulation of transient receptor potential vanilloid 1 (TRPV1) and P2X purinoceptor 3 (P2X3): Implication in burning mouth syndrome

Sex-dependent variation in cartilage adaptation: from degeneration to regeneration

Low back pain and osteoarthritis pain: a perspective of estrogen

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