Estrogen Regulation of the human PEMT (phosphatidylethanolamine N‐methyltransferase) gene

Resseguie, Mary; Song, Jun; Costa, Kerry-Ann da; Wang, Shuli; Kozyreva, O. V.; Zeisel, Steven H.

doi:10.1096/fasebj.20.4.a612-c

Cited by 2 publications

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“…However, the liver employs an additional pathway catalyzed by phosphatidylethanolamine N-methyltransferase (PEMT), which converts PE to PC using three methyl groups from S-adenosylmethionine 45 . Interestingly, PEMT activity exhibits sexual dimorphism 46 and the Pemt gene is regulated by estrogen 47 , 48 . Furthermore, Pemt −/− mice on a high-fat diet display sex-specific differences in their plasma lipoprotein profiles 49 .…”

Section: Discussionmentioning

confidence: 99%

Deficiency of the lipid flippase ATP10A causes diet-induced dyslipidemia in female mice

Norris,

Yazlovitskaya,

Zhu

et al. 2024

Sci Rep

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Genetic association studies have linked ATP10A and closely related type IV P-type ATPases (P4-ATPases) to insulin resistance and vascular complications, such as atherosclerosis. ATP10A translocates phosphatidylcholine and glucosylceramide across cell membranes, and these lipids or their metabolites play important roles in signal transduction pathways regulating metabolism. However, the influence of ATP10A on lipid metabolism in mice has not been explored. Here, we generated gene-specific Atp10A knockout mice and show that Atp10A−/− mice fed a high-fat diet did not gain excess weight relative to wild-type littermates. However, Atp10A−/− mice displayed female-specific dyslipidemia characterized by elevated plasma triglycerides, free fatty acids and cholesterol, as well as altered VLDL and HDL properties. We also observed increased circulating levels of several sphingolipid species along with reduced levels of eicosanoids and bile acids. The Atp10A−/− mice also displayed hepatic insulin resistance without perturbations to whole-body glucose homeostasis. Thus, ATP10A has a sex-specific role in regulating plasma lipid composition and maintaining hepatic liver insulin sensitivity in mice.

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Section: Discussionmentioning

confidence: 99%

Deficiency of the lipid flippase ATP10A causes diet-induced dyslipidemia in female mice

Norris,

Yazlovitskaya,

Zhu

et al. 2024

Sci Rep

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Utilizing Flaxseed as an Antimicrobial Alternative in Chickens: Integrative Review for Salmonella enterica and Eimeria

Weston,

Hales,

Hales

2024

CIMB

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This review provides an integrative framework for understanding flaxseed (Linum utassitissimum) as an antimicrobial alternative for poultry production. We begin by familiarizing the reader with the global legislation of antibiotics in animal husbandry; highlighting gaps and current issues for Salmonella enterica (S. enterica) and Eimeria (coccidiosis-inducing). We then discuss the natural, symbiotic characteristics of the Galliformes order (chicken-like birds) and Linum (the flaxes). The key immunological themes in this review include: (i) flaxseed’s regulation of innate and adaptive immunity in chickens, (ii) flaxseed’s ability to accelerate chicken recovery from infection with S. enterica and Eimeria, and (iii) flaxseed’s strengthening of immunity via vitamin B6 antagonism. Research indicates that whole flaxseed increases adaptive immune capacity by augmenting cecal Bacteroides and short-chain fatty acids while also attenuating the heterophil to lymphocyte ratio in chickens. Moreover, flaxseed accelerates chicken recovery from infection with Salmonella Enteritidis or Eimeria tenella; however, future work is needed to better understand (i) defatted flaxseed’s superior performance against Eimeria species and (ii) Eimeria maxima’s resilience against whole flaxseed. In the context of vitamin B6 antagonism, we propose that 15% whole flaxseed overcomes S. enterica’s insult to estrogen synthesis by sustaining the activity of phosphatidylethanolamine methyltransferase (PEMT) in liver. We also propose that 10% defatted flaxseed (as a metformin homologue) strengthens chicken immunity by safeguarding gonadal physiology and by increasing plasma thymidine bioavailability. The concepts in this review can be used as a template for conducting advanced immunological studies in poultry science.

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Estrogen Regulation of the human PEMT (phosphatidylethanolamine N‐methyltransferase) gene

Cited by 2 publications

References 0 publications

Deficiency of the lipid flippase ATP10A causes diet-induced dyslipidemia in female mice

Deficiency of the lipid flippase ATP10A causes diet-induced dyslipidemia in female mice

Utilizing Flaxseed as an Antimicrobial Alternative in Chickens: Integrative Review for Salmonella enterica and Eimeria

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