2020
DOI: 10.1186/s40170-020-00234-5
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Estrogen-related receptor alpha directly binds to p53 and cooperatively controls colon cancer growth through the regulation of mitochondrial biogenesis and function

Abstract: Background Of the genes that control mitochondrial biogenesis and function, ERRα emerges as a druggable metabolic target to be exploited for cancer therapy. Of the genes mutated in cancer, TP53 remains the most elusive to target. A clear understanding of how mitochondrial druggable targets can be accessed to exploit the underlying mechanism(s) explaining how p53-deficient tumors promote cell survival remains elusive. Methods We performed protein-pr… Show more

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Cited by 15 publications
(12 citation statements)
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“…The orphan acceptor ERRα has been discovered to be related to tumor developmental process, metastasis and chemoresistance [9,10,12,14,26]. Our previous study has pointed out the crucial effect of ERRα in PC development, revealing that ERRα might be a potential diagnosis and treatment target for PC.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…The orphan acceptor ERRα has been discovered to be related to tumor developmental process, metastasis and chemoresistance [9,10,12,14,26]. Our previous study has pointed out the crucial effect of ERRα in PC development, revealing that ERRα might be a potential diagnosis and treatment target for PC.…”
Section: Discussionmentioning
confidence: 99%
“…Emerging evidence suggests that estrogenrelated receptor alpha (ERRα) plays a critical role in carcinogenesis and tumor progression through various mechanisms [8][9][10][11]. In our previous study [10], our team displayed that ERRα was highly expressed in PC patients and promoted the proliferation, migratory and invasive activities of PC cells via MEK/ERK pathway.…”
Section: Introductionmentioning
confidence: 99%
“…Of the known transcription factors involved in mitochondrial biogenesis, p53 is able to bind to phosphorylated CREB and subsequently CREB binding protein (CBP)-a large co-activator complex involved in the majority of cellular processes [195]. Additionally, p53 has been confirmed to bind to the nuclear transcription factor estrogen-related receptor alpha (ERRα) in human embryonic kidney cells [196]. This finding is significant due to ERRα regulating the expression of various OXPHOS and fatty acid oxidation genes, as well as TFAM [197,198].…”
Section: Tumour Protein P53 (P53)mentioning
confidence: 99%
“…Estrogen-related receptor α (ERRα, NR3B1, ESRRA) is a constitutively active ligand-independent orphan nuclear receptor that belongs to the nuclear receptor superfamily 5 . As a transcription factor, ERRα combines with its acknowledged coactivator peroxisome proliferator-activated receptor (PPAR) coactivator-1α (PGC-1α) and plays a central role in the regulation of cellular oxidative phosphorylation and liposome metabolism, resulting in many biological functions 6,7 .…”
Section: Introductionmentioning
confidence: 99%
“…However, the mechanism of lipid metabolism in EC is still unclear.Estrogen-related receptor α (ERRα, NR3B1, ESRRA) is a constitutively active ligand-independent orphan nuclear receptor that belongs to the nuclear receptor superfamily 5 . As a transcription factor, ERRα combines with its acknowledged coactivator peroxisome proliferator-activated receptor (PPAR) coactivator-1α (PGC-1α) and plays a central role in the regulation of cellular oxidative phosphorylation and liposome metabolism, resulting in many biological functions 6,7 .Consistent with an increasing number of studies on breast cancer 8 , colon cancer 9 and ovarian cancer 10 , our previous works con rmed that high expression of ERRα was signi cantly related to a poor prognosis in EC 10 . Moreover, overexpression of ERRα can downregulate the expression of E-cadherin while upregulating the expression of vimentin and inducing epithelial-mesenchymal transformation (EMT), which promotes invasion and migration, indicating that it may be a new biomarker for predicting the risk of deep myometrial invasion and metastasis 11 .…”
mentioning
confidence: 99%