Estrogen related receptor is required for the testicular development and for the normal sperm axoneme/mitochondrial derivatives in Drosophila males

Misra, Snigdha; Pandey, Anuj Kumar; Gupta, Snigdha; Kumar, Ajay; Khanna, Priyanka; Shankar, Jai; Ram, K. Ravi

doi:10.1038/srep40372

Cited by 42 publications

(23 citation statements)

References 72 publications

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“…Finally, Esrrb could be indirectly contributing to germline development by exerting a function in somatic gonadal tissues. A recent study using drosophila as a model to evaluate the effect of depleting genes linked to azoospermia in human males , revealed a role for ERRs in testis morphogenesis . Nonetheless, it should be pointed out that during murine development, Esrrb expression in the gonads is confined to PGCs .…”

Section: The Role Of Esrrb During Development Lessons From Ko Studiesmentioning

confidence: 99%

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Esrrb, an estrogen‐related receptor involved in early development, pluripotency, and reprogramming

2017

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Estrogen-related receptor b (Esrrb) is part of a family of three orphan nuclear receptors with broad expression profiles and a generic function in regulating energy metabolism in mammals. However, Esrrb performs specific functions during early mouse development, in pluripotent and multipotent populations of the embryo as well as in primordial germ cells. Moreover, Esrrb also impinges upon the control of self-renewal in embryo-derived stem cells and enhances reprogramming. Here, we review the function of Esrrb with special emphasis on its role in pluripotency. Esrrb activity at crucial regulatory elements of the pluripotency network, coupled with its role as a mitotic bookmarking factor and the ability to reset cellular metabolism, might explain its potent functions in ensuring the stability of pluripotency and driving the late stages of reprogramming. Hence, we argue that Esrrb represents a key addition to the pantheon of transcription factors sustaining pluripotent stem cell identity in mice. Understanding the mechanisms governing the interplay between different estrogen-related receptors (ERRs) and their specificity of action may clarify the role these factors play during preimplantation development and in pluripotent cells in both mouse and humans.

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Section: The Role Of Esrrb During Development Lessons From Ko Studiesmentioning

confidence: 99%

“…males [64], revealed a role for ERRs in testis morphogenesis [65]. Nonetheless, it should be pointed out that during murine development, Esrrb expression in the gonads is confined to PGCs [41].…”

mentioning

confidence: 99%

Esrrb, an estrogen‐related receptor involved in early development, pluripotency, and reprogramming

2017

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“…Mutations in ERR are lethal in larval development, indicating that the gene plays an essential function. A recent study showed that ERR is required for normal spermatogenesis in the fly [197], but the essential function remains undescribed. ERR orthologs are present in Lophotrochozoa and Echinodermata, but were apparently lost from nematode lineages.…”

Section: Err (Nr3b)mentioning

confidence: 99%

Conserved and Exapted Functions of Nuclear Receptors in Animal Development

Bodofsky¹,

Koitz²,

Wightman³

2017

Nuclear Receptor Research

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The nuclear receptor gene family includes 18 members that are broadly conserved among multiple disparate animal phyla, indicating that they trace their evolutionary origins to the time at which animal life arose. Typical nuclear receptors contain two major domains: a DNA-binding domain and a C-terminal domain that may bind a lipophilic hormone. Many of these nuclear receptors play varied roles in animal development, including coordination of life cycle events and cellular differentiation. The well-studied genetic model systems of Drosophila, C. elegans, and mouse permit an evaluation of the extent to which nuclear receptor function in development is conserved or exapted (repurposed) over animal evolution. While there are some specific examples of conserved functions and pathways, there are many clear examples of exaptation. Overall, the evolutionary theme of exaptation appears to be favored over strict functional conservation. Despite strong conservation of DNA-binding domain sequences and activity, the nuclear receptors prove to be highly-flexible regulators of animal development.

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“…In invertebrates, only one ERR has been discovered thus far ( Sluder, Mathews, Hough, Yin, & Maina, 1999;Dehal et al, 2002;Sullivan & Thummel, 2003;Thomson, Baldwin, Wang, Kwon, & LeBlanc, 2009). A study has shown that ERR may be related to male fertility in Drosophila melanogaster (Misra et al, 2017). In crustaceans, a unique ERR gene has been found in the crab Scylla paramamosain (GenBank: GU290313.1) and Portunus trituberculatus (GenBank: KM189915.1), but reports on the function of ERR in crustaceans are rare.…”

Section: Molecular Characterization Of Estrogen-related Receptor (Errmentioning

confidence: 99%

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Liu¹,

Chen²,

Zhao³

et al. 2019

Turk. J. Fish. Aquat. Sci.

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Nonylphenol (NP) is a xenoestrogen whose estrogenic effects are mediated by the estrogen receptor (ER) in vertebrates. However, the ER appears to be absent in arthropods. Estrogen-related receptor (ERR) may be a candidate that responds to NP. To investigate the effects and mechanisms of NP in giant freshwater prawn Macrobrachium rosenbergii, a unique homolog of mammalian ERR was cloned from M. rosenbergii by rapid amplification of cDNA ends. The full length ERR cDNA consisted of 1897 bp with a 1374 bp open reading frame encoding 457 amino acid residues. RT-PCR analysis revealed that ERR was widely expressed in various tissues of male and female M. rosenbergii, including the brain ganglion, hepatopancreas, heart, and gonads. Interestingly, expression of ERR in ovaries was higher than that in testes. qPCR results showed high expression of ERR in ovaries at early developmental stages. NP exposure up-regulated the expression levels of ERR in the ovaries of M. rosenbergii in a time-dependent manner. The current study provides fundamental data to understand the response of ERR to NP exposure in M. rosenbergii. Aubin, 2001). It has been demonstrated that ERRs are constitutive transcriptional factors that activate expression of target genes via interactions with coactivators in the absence of exogenous ligands (Hong, Yang, & Stallcup, 1999; Schreiber, Knutti, Brogli, Uhlmann, & Kralli, 2003). Although the functions of ERRs are not well understood, they likely play important roles in animal reproduction, growth, development, and metabolism because their expression in embryonic and adult tissues occurs in very restricted spatiotemporal patterns (Giguère, 2002). In mammals, ERRs are involved in ER-dependent pathways related to the formation of bone and cancer development. For

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Estrogen related receptor is required for the testicular development and for the normal sperm axoneme/mitochondrial derivatives in Drosophila males

Cited by 42 publications

References 72 publications

Esrrb, an estrogen‐related receptor involved in early development, pluripotency, and reprogramming

Esrrb, an estrogen‐related receptor involved in early development, pluripotency, and reprogramming

Conserved and Exapted Functions of Nuclear Receptors in Animal Development

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