1998
DOI: 10.1159/000045193
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Estrogen Replacement Therapy with Its Physiological Dose Does Not Eliminate the Aggravating Effect of Ovariectomy on Glomerular Injury in Hypercholesterolemic Female Imai Rats

Abstract: Hypercholesterolemic Imai rats spontaneously develop proteinuria and glomerulosclerosis, especially in males. Estrogen administration attenuated glomerular injury in male Imai rats, and the aggravating effect of ovariectomy in female rats is found. To clarify whether this aggravating effect of ovariectomy is due to a lack of estrogen, we administered estrogen to ovariectomized female Imai rats. At 6 weeks of age, group 1 (control) was sham-operated and group 2 was ovariectomized. Groups 3 and 4 were ovariectom… Show more

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Cited by 11 publications
(16 citation statements)
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“…Because of this higher susceptibility of male Imai rats to focal and segmental glomerulosclerosis, we previously studied the effects of sex hormones on the development of glomerular injury both in male and in female Imai rats [4, 5, 6, 7]. We found that estrogen replacement therapy does not eliminate the aggravating effect of ovariectomy on glomerular injury and rather aggravates it [8]. Furthermore, estrogen treatment of intact female Imai rats enhanced glomerular injury even when injected before or after the ovarian dysfunction may develop [8].…”
Section: Introductionmentioning
confidence: 99%
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“…Because of this higher susceptibility of male Imai rats to focal and segmental glomerulosclerosis, we previously studied the effects of sex hormones on the development of glomerular injury both in male and in female Imai rats [4, 5, 6, 7]. We found that estrogen replacement therapy does not eliminate the aggravating effect of ovariectomy on glomerular injury and rather aggravates it [8]. Furthermore, estrogen treatment of intact female Imai rats enhanced glomerular injury even when injected before or after the ovarian dysfunction may develop [8].…”
Section: Introductionmentioning
confidence: 99%
“…We found that estrogen replacement therapy does not eliminate the aggravating effect of ovariectomy on glomerular injury and rather aggravates it [8]. Furthermore, estrogen treatment of intact female Imai rats enhanced glomerular injury even when injected before or after the ovarian dysfunction may develop [8]. Recently, similar aggravating effect of estrogen replacement therapy has been reported in female analbuminemic rats [9]and in female obese Zucker rats [10]in association with an increase in triglycerides and cholesterol.…”
Section: Introductionmentioning
confidence: 99%
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“…Hiperkolesterolemik ‹mai ratlarda ooferektominin, üriner protein at›l›m›n› önemli derecede de¤ifltirmezken glomerüler hasar› artt›rd›¤›, ooferektomi sonras› histolojik incelemelerde, fokal segmental glomerüler hyalinizasyon ve glomerüler kapiller lümeninde obliterasyonun varl›¤› rapor edilmifltir (23) . Hiperkolesterolemik ‹mai ratlarda yap›lan çal›flmaya ters olarak obez Zucker ratlarda ise anormal proteinürinin, ooferektomi sonras› normale döndü¤ü gösterilmifltir (24) .…”
Section: Ratlarda Yap›lan çAl›flmalarda Ert'nin Hiperlipidemik Analbuunclassified
“…Kardiyovasküler mortalite ile iliflkisi ayn› zamanda diabetik olmayan hastalarda ve Tip II DM'lu hastalarda da rapor edilmifltir (18,26) . (6,23,24) .…”
Section: Reprodüktif Dönemde Oral Kontraseptif (Ok) Veunclassified