Estrogen signaling in healthy and tumor brain

Hirtz, Alex; Rech, Fabien; Dubois-Pot-Schneider, Hélène; Dumond, Hélène

doi:10.1016/j.steroids.2023.109285

Cited by 3 publications

(1 citation statement)

References 76 publications

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“…In addition to interacting with classic nuclear receptors, estrogen can also bind to membranous G protein-coupled estrogen receptor 1 (GPER1) located on the cell membrane [4,5]. GPER1, commonly referred to as GPR30 (G protein-coupled receptor 30), is predominantly situated on the membrane of the endoplasmic reticulum and mitochondria, where it functions in fast nongenomic signaling [6,7]. The presence of the membranous estrogen receptor contributes tremendously to the functional versatility of estrogen.…”

Section: Introductionmentioning

confidence: 99%

Correlation between the RNA Expression and the DNA Methylation of Estrogen Receptor Genes in Normal and Malignant Human Tissues

Rong,

Xie,

Niu

et al. 2024

CIMB

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Estrogen plays a multifaceted function in humans via interacting with the estrogen receptors ERα, ERβ, and G protein-coupled estrogen receptor 1 (GPER1). Previous research has predominantly concentrated on elucidating the signaling route of estrogen. However, the comprehensive understanding of the expression profile and control of these estrogen receptors in various human tissues is not well known. In the present study, the RNA levels of estrogen receptors in various normal and malignant human tissues were retrieved from the human protein atlas, the cancer genome atlas (TCGA), and the genotype-tissue expression (GTEx) databases for analyzing the expression profile of estrogen receptors through gene expression profiling interactive analysis (GEPIA). The status of DNA methylation of estrogen receptor genes from TCGA were analyzed through the software Wanderer and cBioPortal. The MethSurv tool was utilized to estimate the relevance between specific cytosine–guanine (CG) methylation and tumor survival. The expression profile analysis revealed that ERα, ERβ, and GPER1 have unique expression patterns in diverse tissues and malignancies. The interesting results were the higher expression of ERβ RNA in the male testis than in females and the positive association between the RNA level of ERα and the androgen receptor in different human normal tissues. Especially, the significant changes in GPER1 expression in multiple malignancies showed a consistent decrease with no exception, which indicates the role of GPER1 in common tumor inhibition. The finding on the expression profile provides clues for exploring novel potential physiological and pathophysiological functions of estrogen. The DNA methylation analysis manifested that the expression of GPER1 and ERα showed a substantial correlation with the methylation of specific CG sites in the cis-regulating region of the gene. However, no such association was observed for ERβ. When comparing tumor tissues to normal tissues, the DNA methylation of certain CG sites of estrogen receptors showed a correlation with tumor survival but did not always correlate with the expression of that gene or with the expression of DNA methyltransferases. We proposed that the variation in DNA methylation at different CG sites in estrogen receptor genes had other functions beyond its regulatory role in its gene expression, and this might be associated with the progression and therapy efficiency of the tumor based on the modulation of the chromatin configuration.

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Section: Introductionmentioning

confidence: 99%

Correlation between the RNA Expression and the DNA Methylation of Estrogen Receptor Genes in Normal and Malignant Human Tissues

Rong,

Xie,

Niu

et al. 2024

CIMB

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Modeling methamphetamine use disorder and relapse in animals: Short- and long-term epigenetic, transcriptional., and biochemical consequences in the rat brain

Elhadi,

Daiwile,

Cadet

2023

Neuroscience & Biobehavioral Reviews

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Causal relationship between genetically predicted uterine leiomyoma and cancer risk: a two-sample Mendelian randomization

Zhao,

Shang,

et al. 2024

Front. Endocrinol.

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PurposeStudies have demonstrated that hormonal imbalance, such as elevated level of estrogen or reduced level of progesterone, was the main inducing factor of uterine leiomyoma (UL) development and some cancers. UL has been reported to be associated with several cancers in observational studies. However, the causal associations between UL and cancers remain unclear.MethodsA two-sample Mendelian randomization (MR) analysis was conducted to investigate the causal associations between UL and 16 site-specific cancers using the public databases. Four methods, namely, the inverse variance weighting (IVW), MR-Egger, weighted median, and weighted mode, were applied in our MR analysis. Sensitivity tests were also performed to evaluate the robustness of these causal associations.ResultsThe IVW analysis indicated that genetically predicted UL increased the risk of low malignant potential ovarian cancer [odds ratio (OR) = 1.22, 95% confidence interval (CI): 1.06–1.40, p = 0.004], serous ovarian cancer (OR = 1.29, 95% CI: 1.10–1.52, p = 0.002), invasive mucinous ovarian cancer (OR = 1.24, 95% CI: 1.08–1.44, p = 0.003), clear cell ovarian cancer (OR = 1.25, 95% CI: 1.03–1.51, p = 0.023), breast cancer (OR = 1.07, 95% CI: 1.02–1.11, p = 0.002), and brain tumor (OR = 1.23, 95% CI: 1.06–1.42, p = 0.007). Conversely, genetically predicted UL reduced the risk of gastric cancer (OR = 0.91, 95% CI: 0.85–0.98, p = 0.008). The causal effects were consistent in the sensitivity analysis.ConclusionsOur results demonstrated that UL exhibits a causal relationship with high risk of several cancers. We suggest reinforcing the cancer screening in UL patients to enable the early detection of cancers.

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Estrogen signaling in healthy and tumor brain

Cited by 3 publications

References 76 publications

Correlation between the RNA Expression and the DNA Methylation of Estrogen Receptor Genes in Normal and Malignant Human Tissues

Correlation between the RNA Expression and the DNA Methylation of Estrogen Receptor Genes in Normal and Malignant Human Tissues

Modeling methamphetamine use disorder and relapse in animals: Short- and long-term epigenetic, transcriptional., and biochemical consequences in the rat brain

Causal relationship between genetically predicted uterine leiomyoma and cancer risk: a two-sample Mendelian randomization

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