Estrogen sulfurylation as an alternative indicator of hormone dependence in human breast cancer

Pewnim, Thanit; Adams, J.B.; Ho, K.P.

doi:10.1016/0039-128x(82)90124-6

Cited by 28 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For example, Raju et al (1980) indicated that ST activity tended to be lower in ER-negative tumours compared with those that contained the receptor. Other laboratories have suggested that ST activity could be used as an alternative indicator of likely response to endocrine therapy (Pewnim et al 1982, Tseng et al 1983, Adams et al 1989. A single study on the detection of ST protein in breast tumours using immunocyto¬ chemical methods has been published to date.…”

Section: St Functionsmentioning

confidence: 97%

Oestrogen sulphotransferases in malignant and normal human breast tissue

Anderson¹,

Howell²

1995

Endocrine Related Cancer

View full text Add to dashboard Cite

Section: St Functionsmentioning

confidence: 97%

Oestrogen sulphotransferases in malignant and normal human breast tissue

Anderson¹,

Howell²

1995

Endocrine Related Cancer

View full text Add to dashboard Cite

“…It is interesting to mention that some groups report a positive correlation between the expression of SULT1E1 and that of ER in human breast cancer cell lines and tumors. Patients whose tumors presented no SULT activity failed to respond to adrenalectomy and had a poor prognosis 33,35 …”

Section: Sult Expression and Its Control In Breast Cancermentioning

confidence: 99%

“…Patients whose tumors presented no SULT activity failed to respond to adrenalectomy and had a poor prognosis. 33,35 A study on the effects of the progestin promegestone (R-5020) on hEST1 (now named SULT1A3 mRNA) and the formation of estrogen sulfates in the T-47D and MCF-7 cells showed that at low doses of R-5020 there was a significant increase of mRNA levels in these breast cancer cell lines. This was accompanied by an increased formation of estrogen sulfates in these cell lines following the treatment.…”

Section: Sult Expression and Its Control In Breast Cancermentioning

confidence: 99%

Estrogen Sulfotransferases in Breast and Endometrial Cancers

Pasqualini¹

2009

Annals of the New York Academy of Sciences

View full text Add to dashboard Cite

Estrogen sulfotransferase is significantly more active in the normal breast cell (e.g., Human 7) than in the cancer cell (e.g., MCF-7). The data suggest that in breast cancer sulfoconjugated activity is carried out by another enzyme, the SULT1A, which acts at high concentration of the substrates. In breast cancer cells sulfotransferase (SULT) activity can be stimulated by various progestins: medrogestone, promegestone, and nomegestrol acetate, as well as by tibolone and its metabolites. SULT activities can also be controlled by other substances including phytoestrogens, celecoxib, flavonoids (e.g., quercetin, resveratrol), and isoflavones. SULT expression was localized in breast cancer cells, which can be stimulated by promegestone and correlated with the increase of the enzyme activity. The estrogen sulfotransferase (SULT1E1), which acts at nanomolar concentration of estradiol, can inactivate most of this hormone present in the normal breast; however, in the breast cancer cells, the sulfotransferase denoted as SULT1A1 is mainly present, and this acts at micromolar concentrations of E(2). A correlation was postulated among breast cancer cell proliferation, the effect of various progestins, and sulfotransferase stimulation. In conclusion, it is suggested that factors involved in the stimulation of the estrogen sulfotransferases could provide new possibilities for the treatment of patients with hormone-dependent breast and endometrial cancers.

show abstract

“…The finding of a significantly greater proportion of 3H-oestradiol in breast tumours compared with normal tissues after 'H-oestrone infusion suggests that conversion of oestrone to oestradiol is enhanced in tumour tissue. It is likely that oestrone will also be in equilibrium with oestrone sulphate within these tissues as both sulpho-transferase and -kinase enzymes are present in breast tissues (Penwim et al, 1982). This may account for the relatively greater proportion of 'Hoestrone seen in tumour and normal breast tissues after 'H-oestrone infusion.…”

Section: Referencesmentioning

confidence: 99%

A comparison of the in vivo uptake and metabolism of ³H‐oestrone and ³H‐oestradiol by normal breast and breast tumour tissues in post‐menopausal women

McNeill

Reed

Beranek

et al. 1986

Intl Journal of Cancer

View full text Add to dashboard Cite

After infusion of 3H-oestradiol or 3H-oestrone into post-menopausal women with breast cancer, there was a significant uptake of both steroids by breast tumour and normal tissue. The proportion of oestrogen present in tumour tissue as 3H-oestradiol after infusion of 3H-oestradiol (89.4 +/- 3.5%, mean +/- SD, n = 4) was significantly higher (p less than 0.001) than in normal breast tissue (72.8 +/- 3.3%) obtained from the same women. Similarly, after infusion of 3H-oestrone, the proportion of oestrogen present as 3H-oestradiol (48.4 +/- 14.4%) was significantly higher than in normal breast tissue (19.1 +/- 6.4%). These results suggest that conversion of oestrone to oestradiol is enhanced in breast tumour tissue with little metabolism of oestradiol. This would account for the higher concentrations of oestradiol reported in breast tumour tissue in the presence of increased oestradiol 17 beta-hydroxysteroid dehydrogenase activity.

show abstract

Estrogen sulfurylation as an alternative indicator of hormone dependence in human breast cancer

Cited by 28 publications

References 0 publications

Oestrogen sulphotransferases in malignant and normal human breast tissue

Oestrogen sulphotransferases in malignant and normal human breast tissue

Estrogen Sulfotransferases in Breast and Endometrial Cancers

A comparison of the in vivo uptake and metabolism of ³H‐oestrone and ³H‐oestradiol by normal breast and breast tumour tissues in post‐menopausal women

Contact Info

Product

Resources

About

Estrogen sulfurylation as an alternative indicator of hormone dependence in human breast cancer

Cited by 28 publications

References 0 publications

Oestrogen sulphotransferases in malignant and normal human breast tissue

Oestrogen sulphotransferases in malignant and normal human breast tissue

Estrogen Sulfotransferases in Breast and Endometrial Cancers

A comparison of the in vivo uptake and metabolism of 3H‐oestrone and 3H‐oestradiol by normal breast and breast tumour tissues in post‐menopausal women

Contact Info

Product

Resources

About

A comparison of the in vivo uptake and metabolism of ³H‐oestrone and ³H‐oestradiol by normal breast and breast tumour tissues in post‐menopausal women