Estrogenic and Hypocholesterolemic Effects of Aqueous Extract of Nicotiana tabacum (Tobacco) on the Micro-Anatomical Architecture of the Testis in Male Albino Wistar Rats

Abstract

Aim:The aim of this study was to investigate the effect of aqueous extract of Nicotiana tabacum on the testicular function and micro-architectural integrity in male Albino Wistar rats in relation to the serum concentrations of estradiol, cholesterol, testis and body weights. Study Design: The experiment was carried out on Albino Wistar Rats. Methodology: A total of 18 male Albino Wistar rats aged 8 to 10 weeks and weighing 140 to 220 g was used. Aqueous extract of N. tabacum at the doses of 20 and 30 mg/kg body weight were orally administered to groups B and C, respectively while 0.5 ml of distilled water was administered to group A (Control) for 28days. Serum concentration of estradiol (E2) and total cholesterol were estimated using the microplate enzyme

Review: Germinal Cell Apoptosis by Herbal Medicine

“…N. tabacum also acted by suppressing testosterone biosynthesis, reducing mRNA levels, Bcl-2 protein, regulating p53, caspase-3 mRNA, and protein levels that may affect spermatogenesis [108]. Aqueous extract of N. tabacum was considered as a potential endocrine disruptor that may affect the micro-anatomical form and testicular function [109]. However, N. tabacum showed a slight effect on body weight although this effect was significantly low [110].…”