2021
DOI: 10.18370/2309-4117.2021.59.8-12
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Estrogens and female developing brain: two sides of the coin

Abstract: The review highlights current views and hypotheses on the pathogenetic role of natural and xenoestrogens in the disorders of programming of neuroendocrine regulation of reproduction, alaptation, and various forms of instinctive behavior (reproductive, eating, parental, etc.) in the perinatal period of development of the female brain. Catecholestrogens, which are formed in the brain as a result of sequential metabolic conversions of testosterone, are involved in exogenous or endogenous androgen-induced defemini… Show more

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“…Animals were kept on a standard vivarium diet. 26,27 Substances were administered once intraperitoneally (i/p) in the form of a thin aqueous suspension in saline (Tween 80 stabilizer) or as a solution (for water-soluble substances) with a volume not exceeding 1 mL. The four groups of animals were studied, each consisted of 2 animals.…”
Section: Toxicity Testsmentioning
confidence: 99%
“…Animals were kept on a standard vivarium diet. 26,27 Substances were administered once intraperitoneally (i/p) in the form of a thin aqueous suspension in saline (Tween 80 stabilizer) or as a solution (for water-soluble substances) with a volume not exceeding 1 mL. The four groups of animals were studied, each consisted of 2 animals.…”
Section: Toxicity Testsmentioning
confidence: 99%