Estrogens and their receptors in the medial amygdala rapidly facilitate social recognition in female mice

Lymer, Jennifer; Sheppard, Paul A. S.; Kuun, Talya; Blackman, Andrea; Jani, Nilay; Mahbub, Sahnon; Choleris, Elena

doi:10.1016/j.psyneuen.2017.12.021

Cited by 55 publications

(53 citation statements)

References 40 publications

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“…Estrogens and their receptors in the medial AMY rapidly facilitate social recognition in female mice (Lymer et al . ). A recent study in the AMY of the guinea pig reported that in various nuclei of the AMY, small subsets of CB neurons and substantial proportions of PV neurons co‐express ERβ, whereas many of the CR neurons co‐express ERα.…”

Section: Discussionmentioning

confidence: 97%

“…Our previous studies noted that ERa rescue is effective in improving the hippocampal-dependent cognition deficit after long-term ovariectomy (Qu et al 2013(Qu et al , 2016. Estrogens and their receptors in the medial AMY rapidly facilitate social recognition in female mice (Lymer et al 2018). A recent study in the AMY of the guinea pig reported that in various nuclei of the AMY, small subsets of CB neurons and substantial proportions of PV neurons co-express ERb, whereas many of the CR neurons co-express ERa.…”

Section: Discussionmentioning

confidence: 99%

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Evidence of altered depression and dementia‐related proteins in the brains of young rats after ovariectomy

Fang

Zeng

et al. 2018

Journal of Neurochemistry

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Menopause, a risk factor for brain dysfunction in women, is characterized by neuropsychological symptoms including depression and dementia, which are closely related to alterations in different brain regions after menopause. However, little is known about the variability in pathophysiologic changes associated with menopause in the brain. Here, we observed that menopause in rats induced by bilateral ovariectomy (OVX) showed depressive and dementia-related behaviors along with neuronal loss in the prefrontal cortex (PFC), hippocampus (HIP), hypothalamus (HYP), and amygdala (AMY) by Nissl staining. Meanwhile, by immunohistochemical staining, increased microglia in the HIP and AMY and increased astrocytes in the PFC, HYP, and AMY were shown. Using quantitative proteomics, we identified 146 differentially expressed proteins in the brains of OVX rats, for example, 20 in the PFC, 41 in the HIP, 17 in the HYP, and 79 in the AMY, and performed further detection by western blotting. A link between neuronal loss and apoptosis was suggested, as evidenced by increases in adenylate kinase 2 (AK2), B-cell lymphoma 2 associated X (Bax), cleaved caspase 3, and phosphorylated p53 and decreases in Huntingtin-interacting protein K, hexokinase, and phosphorylated B-cell lymphoma 2 (Bcl-2), and apoptosis might be triggered by endoplasmic reticulum stress (probed by increased glucose-regulated protein 78 (GRP78), cleaved caspase 12, phosphorylated protein kinase R (PKR)-like endoplasmic reticulum kinase, inositol-requiring enzyme-1 and activating transcription factor 6), and mitochondrial dysfunction (probed by increased cytochrome c and cleaved caspase 3 and decreased sideroflexin-1 (SFXN1) and NADH dehydrogenase (ubiquinone) 1 α subcomplex 11 (NDUFA11)). Activation of autophagy was also indicated by increased autophagy-related 7, γ-aminobutyric acid (GABA) receptor-associated protein-like 2, and oxysterol-binding protein-related protein 1 and confirmed by increased microtubule-associated protein light chain 3 (LC3II/I), autophagy-related 5, and Beclin1 in the HIP and AMY. In the AMY, which is important in emotion, higher GABA transporter 3 and lower vesicular glutamate transporter 1 levels indicated an imbalance between excitatory and inhibitory neurotransmission, and the increased calretinin and decreased calbindin levels suggested an adjustment of GABAergic transmission after OVX. In addition, cytoskeletal abnormalities including tau hyperphosphorylation, dysregulated Ca² signals, and glutamic synaptic impairments were observed in the brains of OVX rats. Collectively, our study showed the changes in different brain regions related to depression and dementia during menopause.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Evidence of altered depression and dementia‐related proteins in the brains of young rats after ovariectomy

Fang

Zeng

et al. 2018

Journal of Neurochemistry

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“…The most studied ERs are ERα, ERβ and the G protein coupled ER 1 (GPER1) which can mediate both rapid non‐genomic and the more delayed and lasting classical genomic effects . ERα and GPER1 have been shown to rapidly facilitate social recognition and social learning with the effects of ERβ being less well defined . Estrogenic mechanism and ERα and ERβ have been implicated in the expression of disgust and pathogen/toxin avoidance.…”

Section: Neurobiology Of Disgust and Pathogen/toxin Avoidancementioning

confidence: 99%

“…All three ER receptors are expressed in the medial amygdala where they enhance social recognition and likely are associated with the functioning of the OTR . Estrogens in the paraventricular nucleus rapidly facilitate social recognition, an effect that was blocked by OTR antagonists in the amygdala (, in preparation), while estrogens in medial preoptic area of female mice have been associated with the rewarding effects of male odors facilitating dopamine release at the level of the ventral tegmental area . It is possible that such interactive mechanism may be associated with the expression of pathogen and toxin disgust associated with ERs.…”

Section: Neurobiology Of Disgust and Pathogen/toxin Avoidancementioning

confidence: 99%

“…Gonadal steroid hormones have an important role in the regulation of social behaviors with estrogenic systems, in particular, being involved in the regulation of the expression and utilization of social information. 20,87,106,107 This ranges from the detection and processing of olfactory information to odor production, social recognition, social learning to the expression of complex social behaviors including sexual behavior. These effects are mediated through a number of estrogen receptors (ERs).…”

Section: Estrogens Disgust and Pathogen/toxin Avoidancementioning

confidence: 99%

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Social neuroscience of disgust

Kavaliers

Ossenkopp

Choleris

2018

Genes Brain and Behavior

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Disgust can be thought of as an affective system that has evolved to detect signs of pathogens, parasite and toxins as well as to stimulate behaviors that reduce the risk of their acquisition. Disgust incorporates social cognitive mechanisms to regulate exposure to and, or anticipate and avoid exposure to pathogens and toxins. Social cognition entails the acquisition of social information about others (ie, social recognition) and from others (ie, social learning). This involves recognizing and assessing other individuals and the pathogen/parasite/contamination/toxin threat they pose and deciding about when and how to interact with and, or avoid them. Social cognition provides a frame-work for examining the expression of disgust and the associated neurobiological mechanisms. Here, we briefly consider the relations between social cognition and pathogen/parasite/toxin avoidance behaviors. We briefly discuss aspects of: (1) the odor mediated social recognition of actual and potentially infected individuals and the impact of parasite/pathogen threat on disgust mate and social partner choice; (2) the roles of "out-groups" (strangers, unfamiliar individuals) and "in-groups" (familiar individuals) in the expression of disgust and pathogen avoidance behaviors; (3) individual and social learning of disgust and empathy for disgust; (4) toxin elicited disgust and anticipatory disgust; (5) the neurobiological mechanisms, and in particular the roles of the nonapeptide, oxytocin and estrogenic mechanism associated with social cognition and the expression of disgust. These findings on the social neuroscience of disgust have a direct bearing on our understanding of the roles of disgust in shaping human and nonhuman social behavior.

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