Estrous cycle and gastric acid secretion in the rat.

Omole, A. A.

doi:10.1152/jappl.1972.33.6.825

Cited by 6 publications

(8 citation statements)

References 0 publications

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“…Therefore, it is possible that the gastric acid reduction seen in the previous study in response to exogenous female sex hormones is masked in the present study by the presence of the endogenous female sex hormones. This is supported by the reports that ovariectomy causes an increase in acid secretion in the cat (Ojha & Wood, 1950) and the rat (Omole, 1972). A similar argument might be used to explain the lack of change in serum gastrin concentration ( Figure 4) compared with that seen in the earlier study (Albinus et al, 1976).…”

Section: Biliary Secretion Studiessupporting

confidence: 78%

“…There is much epidemiological and experimental evidence that exogenous and endogenous female sex hormones have a beneficial effect on the aetiology of peptic ulceration, and that this effect may be mediated by reduction of gastric acid secretion (Ojha & Wood, 1950;Crean, 1963;Parbhoo & Johnston, 1966;Amure & Omole, 1970;Landor & Wild, 1970;Omole, 1972;Albinus et al, 1976). However, there are many reports where no or inconclusive effects of female sex hormones have been shown (Parbhoo & Johnston, 1966;Doll, Langman & Shawdon, 1968;Kauffmann & Spiro, 1968;Landor & Wild, 1970).…”

Section: Gastric Studiesmentioning

confidence: 99%

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Effects of a Combined Oestrogen‐progestin Preparation on Gastric Acid and Pepsin Secretion, Serum Gastrin Concentration and Biliary Secretion of Bile Acids, Phospholipids, and Cholesterol in the Cat

Hirst

Lund

Sanders

et al. 1979

British J Pharmacology

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4 There was no sign of cholestasis associated with the treatment. Intestinal flow remained constant throughout the study, there was no lithocholic acid or other abnormal bile acids detectable in any samples, and there was no change in serum aspartate aminotransferase concentration. 5 The results suggest that in female cats, treatment with a combined oestrogen-progestin preparation does not exert any beneficial effects on the aetiology of peptic ulceration through the reduction of acid or pepsin secretion, or the lowering of serum gastrin concentration. The preparation shows a tendency to produce more lithogenic bile, and this may partly explain the greater incidence of gall stones in women on the contraceptive pill.

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Section: Biliary Secretion Studiessupporting

confidence: 78%

Section: Gastric Studiesmentioning

confidence: 99%

Effects of a Combined Oestrogen‐progestin Preparation on Gastric Acid and Pepsin Secretion, Serum Gastrin Concentration and Biliary Secretion of Bile Acids, Phospholipids, and Cholesterol in the Cat

Hirst

Lund

Sanders

et al. 1979

British J Pharmacology

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“…Studies in both women and female rat models show that high serum estrogens inhibit gastric acid secretion (Omole 1972, Limlomwongse & Piyachaturawat 1982, Aguwa 1984, Adeniyi 1991, Sakaguchi et al 1991, Girma et al 1997). In the current study, we tested a range of physiological concentrations for 17 -estradiol replacement in Ovx rats and found dose-dependent inhibition up to 60% of stimulated gastric acid output after 1 week of chronic 17 -estradiol therapy in pair-fed animals.…”

Section: Discussionmentioning

confidence: 99%

“…Reciprocal changes in gastric acid secretion versus serum estradiol concentrations were reported during the menstrual cycle (Sakaguchi et al 1991). In rats, basal gastric acid output is similar in females and males, whereas histamine-and pentagastrin-stimulated gastric acid output can be decreased by 17 -estradiol administration (Omole 1972, Limlomwongse & Piyachaturawat 1982, Aguwa 1984, Adeniyi 1991, Girma et al 1997.…”

Section: Introductionmentioning

confidence: 94%

Immunolocalization of estrogen receptor alpha and beta in gastric epithelium and enteric neurons

Campbell-Thompson¹,

Reyher²,

Wilkinson³

2001

Journal of Endocrinology

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A sexual dimorphism in gastric acid secretion has been known for many years, with women secreting less acid (40%) than men. The mechanisms mediating this sex difference are unknown, but a role for estrogens is suggested from animal models. Two estrogen receptor (ER) subtypes, ER and ER , mediate genomic effects of estrogens, and mRNA for both subtypes has been detected in the rat stomach. The objective of this study was to determine the cellular distribution of ER and ER proteins in the rat stomach. ER and ER proteins were detected in nuclei of fundic parietal cells and epithelial cells in the progenitor zone. In the antrum, several cells were immunoreactive for ER in regions containing stem and neuroendocrine cell types but ER protein was not detected in antral glands. Both ER and ER proteins were expressed in enteric neurons within the nucleus and cytoplasm, with specific punctate staining for ER in cell bodies and fibers. These studies are the first to show differences between ER and ER proteins in the epithelial cellular distribution in the fundus and antrum and to detect co-expression in enteric neurons. These results suggest that estrogens may inhibit gastric acid secretion via genomic effects in fundic parietal cells through either ER subtype and in antral neuroendocrine cells via ER . Moreover, co-expression of ER and ER in enteric neurons indicates that estrogenic effects could also be mediated through neurogenic reflexes. Our findings imply that direct regulation of multiple cell types by estrogens may contribute to the modulation of gastric functions that have been recognized during the estrous cycle and between the sexes.

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“…The mechanism by which estrogen reduces acid gastric secretion is still mainly conjectural. Recently it has been shown (Omole, 1972) that during the di-estrous cycle when the level of estrogen circulating in the blood is very low, the stomach of the female rat is more secretorily active than those of rats in pro-estrous or estrous phase. Table I shows that in the present study the concentration of gastrin stored in the antral mucosa during di-estrous is very high, higher than in pro-estrous or estrous when the blood level estrogen is higher.…”

Section: Discussionmentioning

confidence: 99%