Estructura de la rodopsina: luz en las sombras de las degeneraciones retinianas

Background: Mutations at Gly-90 in rhodopsin cause two different phenotypes: retinitis pigmentosa and congenital night blindness. Results: G90V retinitis pigmentosa mutant shows constitutive activity and very low thermal stability in the dark state. Conclusion: Low conformational stability can trigger retinitis pigmentosa associated with rhodopsin mutations. Significance: Retinoids can help to stabilize the conformation of retinitis pigmentosa mutants.

show abstract

Molecular Mechanisms of Disease for Mutations at Gly-90 in Rhodopsin

Toledo

Ramon

Aguilà

et al. 2011

Journal of Biological Chemistry

Self Cite

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Estructura de la rodopsina: luz en las sombras de las degeneraciones retinianas

Cited by 1 publication

References 54 publications

Molecular Mechanisms of Disease for Mutations at Gly-90 in Rhodopsin

Molecular Mechanisms of Disease for Mutations at Gly-90 in Rhodopsin

Contact Info

Product

Resources

About