“…The following are the most important ones: Physicians Health Study (PHS), Women's Health Study (WHS), Honolulu Heart Study, Nurses Health Study, MONICA (Monitoring Trends and Determinants in Cardiovascular Disease), and Cardiovascular Health Study. 7 Based on such evidence, CRP was included in the 4th Brazilian Guideline of Atherosclerosis Prevention as a risk aggravator, that is, high CRP levels could cause an increase in the cardiovascular risk and change the treatment goals. 3 Ridker et al suggested the inclusion of CRP in a clinical score (Reynolds Risk Score) in order to improve the stratification of cardiovascular risk.…”