Estudio de contactos de pacientes con tuberculosis: organización y prevalencia de la infección tuberculosa latente

Blanco, José Antonio Gullón; Sanz, Teresa Rodrigo; Navascués, Fernando Álvarez; Huguet, Eva Tabernero; Mestres, Josefina Sabría; García-García, José-María

doi:10.1016/j.arbres.2020.12.021

Cited by 2 publications

(1 citation statement)

References 9 publications

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“…In our study, only two-thirds (66.3%) of all patients with an indication for treatment completed the course prescribed, similar to rates found in Canada and the USA by Sullivan and Hirsch-Moverman (10,11), and lower than those of 79% reported in Italy and 80%-89% in two multicenter studies in Spain (7,12,13). A systematic review of 83 studies on this topic described rates ranging from 46% to 96%, depending on the characteristics of the population studied, being much lower in homeless people than in healthcare workers (14).…”

Section: Discussionsupporting

confidence: 86%

Latent tuberculosis infection treatment completion in Biscay: differences between regimens and monitoring approaches

Ortiz Laza,

Lopez Aranaga,

Toral Andres

et al. 2023

Front. Med.

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IntroductionContact tracing and treatment of latent tuberculosis infection (LTBI) is a key element of tuberculosis (TB) control in low TB incidence countries. A TB control and prevention program has been active in the Basque Country since 2003, including the development of the nurse case manager role and a unified electronic record. Three World Health Organization-approved LTBI regimens have been used: isoniazid for 6 months (6H), rifampicin for 4 months (4R), and isoniazid and rifampicin for 3 months (3HR). Centralized follow-up by a TB nurse case manager started in January 2016, with regular telephone follow-up, telemonitoring of blood test results, and monitoring of adherence by electronic review of drugs dispensed in pharmacies.ObjectiveTo estimate LTBI treatment completion and toxicity of different preventive treatment regimens in a real-world setting. Secondary objective: to investigate the adherence to different approaches to preventive treatment monitoring.MethodsA multicentre retrospective cohort study was conducted using data collected prospectively on contacts of patients with TB in five hospitals in Biscay from 2003 to 2022.ResultsA total of 3,066 contacts with LTBI were included. The overall completion rate was 66.8%; 86.5% of patients on 3HR (n = 699) completed treatment vs. 68.3% (n = 1,260) of those on 6H (p < 0.0001). The rate of toxicity was 3.8%, without significant differences between the regimens. A total of 394 contacts were monitored by a TB nurse case manager. In these patients, the completion rate was 85% vs. 67% in those under standard care (p < 0.001). A multivariate logistic regression model identified three independent factors associated with treatment completion: being female, the 3HR regimen, and nurse telemonitoring.Conclusion3HR was well tolerated and associated with a higher rate of treatment completion. Patients with nurse telemonitoring follow-up had better completion rates.

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