Estudio de las resistencias primarias a fármacos antituberculosos en Galicia

Álvarez, D.; Valle, José M. González del; Martino, Marini; Gordo, Patricia Mateos; Carreira, José Nunes; Valdés, Luís

doi:10.1016/s0300-2896(15)31058-9

Cited by 12 publications

(6 citation statements)

References 8 publications

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“…These results are similar to those reported by other workers in different geographical areas of Spain [26–28], which has favorable conditions for increases in both the baseline level of resistance to TB and the development of outbreaks of MDR‐TB. Spain also has the highest cumulative incidence of AIDS in Europe, and the highest rates of coinfection with M. tuberculosis and HIV among developed countries [29].…”

Section: Discussionsupporting

confidence: 91%

Patterns of resistance of Mycobacterium tuberculosis in Spanish patients infected with human immunodeficiency virus type 1 (HIV-1)

Guelar

González-Martín

Gatell

et al. 1995

Clinical Microbiology and Infection

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Objective: To evaluate the resistance and mortality rates of multidrug‐resistant tuberculosis (MDR‐TB) in human immunodeficiency virus type 1 (HIV‐1)‐infected patients in a 1000‐bed teaching hospital in inner‐city Barcelona. Methods: A total of 311 patients, recruited between July 1991 and July 1993, had either tuberculosis (TB) with HIV (group A), TB without HIV (group B), or TB without HIV and previous exposure to antituberculosis drugs (group C). Mycobacterium tuberculosis was isolated radiometrically or using Lowenstein‐Jensen media with p‐nitro‐a‐acetylamino‐B‐hidroxypropiphenone (NAP) testing. Antibiograms to isoniazid, rifampicin, pyrazinamide, ethambutol and streptomycin were performed by the critical proportions method with only one strain per patient. Results: Of 197 strains of M. tuberculosis isolated in group A, six (3%) were resistant to one agent and seven (3.5%) were multiresistant vs five (5.7%) and three (3.4%) of 88 strains, respectively, in group B, and three (11.5%) and seven (26.9%) of 26 strains, respectively, in group C. Conclusions: The primary resistance rate of M. tuberculosis in Spain remains relatively low in both HIV‐infected and non‐HIV‐infected patients in contrast to a nearly 30% or higher resistance rate among patients previously exposed to antituberculosis agents.

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Section: Discussionsupporting

confidence: 91%

Patterns of resistance of Mycobacterium tuberculosis in Spanish patients infected with human immunodeficiency virus type 1 (HIV-1)

Guelar

González-Martín

Gatell

et al. 1995

Clinical Microbiology and Infection

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“…13,14 The multi-resistance rate recorded here (1.9%) is lower than that reported by the authors themselves in an earlier study for the same area (5.8%), and considerably lower than the 34.0%, 10.5%, and 10% reported by Aznar (Madrid), Remacha (León), and Alvarez (Galicia), respectively. 13,15,16 With regard to findings for individual anti-TB drugs, resistance to streptomycin (3.0%) was higher than that reported by all except Aznar (16.9%) and Aragó (6.5%); other authors noted rates similar to those obtained here. [17][18][19][20][21][22][23][24][25] Resistance to isoniazid (5.3%) exceeded that recorded by any other author except Aznar (7.4%), while the ethambutol resistance rate (0.2%) was lower than those obtained by all except Aragó (3.9%) and Aznar (3.3%).…”

Section: Discussionsupporting

confidence: 78%

Surveillance of Drug-Resistant Tuberculosis in Spain (2001–2015)

Gutiérrez-Aroca

Ruiz

Vaquero

et al. 2018

Microbial Drug Resistance

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Multidrug-resistant tuberculosis (MDR-TB) is a cause of increasing concern. This study investigated first-line anti-TB drug resistance in Mycobacterium tuberculosis strains submitted to the Tuberculosis Reference Center in Córdoba (Spain) between 2001 and 2015. A total of 1,207 cultures were tested against first-line drugs using the BACTEC MGIT 960 system. Resistance to first-line drugs was detected in 207 strains (17.2%), the greatest resistance being found in INH (5.3%) followed by streptomycin (3%), pyrazinamide (2.2%), rifampicin (1%), and ethambutol (0.2%). A total of 1.9% of strains were MDR-TB. Six strains displayed resistance to four drugs, and three strains to five drugs. In view of resistance observed, careful surveillance of drug resistance is recommended.

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“…The 1.7% of our PR patients resistant to INH, and the 1.3% of those resistant to S constitute, as mentioned above, a lower rate than figures published recently in Spain [12,13,25,26], and there have been no cases of multiresistance. Our data permit us, we believe, to continue the treatment of TB with three drugs within a limited period of 6 months.…”

Section: Discussionmentioning

confidence: 38%

“…The rate oscillated between 7 and 10% in the 1980s [11,12,24], whilst the studies published in the last 2 years give rates near 5% [13,25,26]. This shows that, at this moment, a downward trend in the rate of PR exists in Spain despite the high prevalence of TB.…”

Section: Discussionmentioning

confidence: 99%

Risk factors associated with drug-resistant Mycobacterium tuberculosis in Castilla-la-Mancha (Spain)

Arevalo¹,

Solera²,

Cebrián³

et al. 1996

Eur Respir J

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The aim of this study was to investigate the incidence of primary and secondary resistance to antituberculosis drugs and the risk factors associated with the resistance in southeast Spain.Our research was based on the clinical histories of 276 patients, diagnosed as having tuberculosis by positive culture, who were tested for drug susceptibility between January 1988 and October 1994. The clinical histories were checked by two independent investigators. Drug-resistant strains were isolated from 24 patients (8.7%). Among the 239 patients without previous tuberculosis therapy, 7 (2.9%) were drug-resistant. Among the 37 patients with previous therapy, 17 (46%) were drug-resistant. Seventeen of the 276 patients (6.2%) had resistance to a single drug. Primary resistance to isoniazid was 1.7%. Previous treatment for tuberculosis (odds ratio (OR) 39.2; 95% confidence interval (95% CI) 10.2-150); hepatic cirrhosis (OR 104; 95% CI 12.8-847); and age 45 yrs and older (OR 4.80; 95% CI 1.15-20.1) were considered risk factors associated with drug-resistant tuberculosis.We conclude that primary and secondary resistance is low in the southeast of Spain and we recommend that susceptibility testing be performed on initial M. tuberculosis isolated from patients with a history of previous tuberculosis therapy, hepatic cirrhosis or more than 44 yrs of age.

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Estudio de las resistencias primarias a fármacos antituberculosos en Galicia

Cited by 12 publications

References 8 publications

Patterns of resistance of Mycobacterium tuberculosis in Spanish patients infected with human immunodeficiency virus type 1 (HIV-1)

Patterns of resistance of Mycobacterium tuberculosis in Spanish patients infected with human immunodeficiency virus type 1 (HIV-1)

Surveillance of Drug-Resistant Tuberculosis in Spain (2001–2015)

Risk factors associated with drug-resistant Mycobacterium tuberculosis in Castilla-la-Mancha (Spain)

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