Estudio del colículo inferior de pacientes con esquizofrenia mediante espectroscopía de resonancia magnética

Análise dos efeitos da modulação GLU cortical sobre a expressão da resposta eletrofisiológica eliciada em ratos tratados com KET e testados em um modelo de condicionamento contextual

“…Aside from the effect on behavior and cognitive function, it has been shown that ketamine can disturb auditory evoked potentials (AEPs) in a way consistent with schizophrenia ; an effect probably related to the sensory overload resulting from the weakening of the inhibitory cortical top-down control on the mesencephalic bottom-up processes, resulting in the induction of psychotic-like symptoms . In humans, these auditory hallucinations are reputed to be due to functional and/or structural abnormalities in several regions of the brain auditory system, among them the inferior colliculus (Martinez-Granados et al, 2014), and the frontal and temporal cortex (Lennox et al, 2000).…”

“…In the midbrain, it has been suggested that ketamine changes primarily auditory signaling by disrupting electrophysiological responses recorded in the auditory colliculi , the most important relay involved in several aspects of behavior as sound-oriented action ), emotionality (Brandão et al, 2003, and personality (Martinez-Granados et al, 2014). The influence of the inferior colliculus on ascending auditory information seems to be under modulation of the auditory cortex (AC) and the primary AC undergoes neuroplasticity that modulates the emotional features of auditory information (Recanzone et al, 1993;McGann, 2015).…”