Estudio del ojo seco en pacientes con aniridia congénita, mediante citología de impresión

Rivas, L; Murube, Juan; Rivas, A; Murube, Eduardo

doi:10.4321/s0365-66912003001100008

Cited by 5 publications

(3 citation statements)

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“…Accordingly, squamous metaplasia is a process utilized by humid epithelia to provisionally overcome attacks. This process involves both corneal and conjunctival epithelial cells as well as the conjunctiva's secreting cells (calliciform cells) (29). This is a pathological and reversible transition of the normal, non-keratinized stratified epithelium to keratinized epithelium.…”

Section: Alterations Of the Ocular Surface In Aniridia Patientsmentioning

confidence: 99%

Manejo terapéutico de la queratopatía asociada a aniridia congénita

López-García

García-Lozano²,

Rivas

et al. 2006

Arch Soc Esp Oftalmol

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The management of ocular surface diseases due to limbal stem cell deficiency in aniridia is complex but has changed in recent years, as an understanding of the limbal stem cells and their microenvironment has modified the therapeutic approach. The use of autologous serum eye drops, amniotic membrane transplantation, limbal transplantation or cultivated limbal cell transplantation have all been reported as a treatment for several ocular surface diseases.

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Section: Alterations Of the Ocular Surface In Aniridia Patientsmentioning

confidence: 99%

Manejo terapéutico de la queratopatía asociada a aniridia congénita

López-García

García-Lozano²,

Rivas

et al. 2006

Arch Soc Esp Oftalmol

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“…En este trabajo planteamos un estudio trasversal para determinar las características citológicas del epitelio corneal en diferentes entidades etiológicas que tienen en común la presencia de un cuadro de deficiencia limbal. Sin embargo, esta diversidad etiológica nos ha de hacer ser prudentes a la hora de generalizar los resultados obtenidos, pues no en todas ellas el daño limbal se produce por los mismos mecanismos patogénicos (19)(20)(21) hemos de tener presente que esta respuesta no se produce sólo por la insuficiencia limbal. Según estas consideraciones, y para tratar de homogeneizar lo máximo posible la muestra, hemos clasificado a los pacientes atendiendo fundamentalmente a parámetros clínicos derivados del grado de deficiencia limbal, sin tener en cuenta otros signos o síntomas característicos de cada entidad.…”

Section: Discussionunclassified

Determinación del grado de metaplasia escamosa del epitelio corneal como factor diagnóstico de insuficiencia limbal

López-García

Rivas

García-Lozano³

2006

Arch Soc Esp Oftalmol

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RESUMENObjetivos: Determinar si existe relación entre el grado de metaplasia escamosa de la superficie corneal mediante citología de impresión y la gravedad clínica en pacientes con insuficiencia limbal. Métodos: Hemos estudiado mediante citología de impresión 98 ojos de pacientes con insuficiencia limbal que fueron divididos en cuatro grupos según la gravedad clínica: 14 ojos no presentaban sintomatología alguna, 34 ojos presentaron un grado leve de insuficiencia limbal, 28 ojos un grado moderado y 22 ojos una insuficiencia limbal grave. A todos los pacientes se les realizó una citología corneal en la que se estudió el tamaño celular, tamaño nuclear, alteraciones nucleares y relación núcleo-citoplasma (N:C), así como la presencia de células caliciformes. Resultados: Los pacientes con insuficiencia limbal asintomática presentaron un tamaño celular medio de 477 DE 140 µm 2 , con una relación N:C de 1:5,25 DE 1,5. Los pacientes con insuficiencia limbal leve presentaron un tamaño celular medio de 764 DE 122,6 µm 2 y una relación N:C de 1:8,2 DE 1,4. Nin- ARTÍCULO ORIGINAL ABSTRACTPurpose: To determine the correlation between the squamous metaplasia grade of the corneal surface and the clinical severity of the limbal deficiency in patients with this disorder. Methods: We studied 98 eyes of patients with limbal deficiency by impression cytology. These patients were divided into four groups in relation to their clinical severity: 14 eyes had no symptoms, 34 eyes showed a mild grade of limbal deficiency, 28 eyes had a moderate grade and 22 eyes had severe limbal deficiency. Corneal cytology was performed in each patient. Cellular size, nuclear size, nuclear changes and the nuclear-cytoplasmic (N:C) ratio were defined in corneal epithelial cells, in addition to evaluation for the presence of goblet cells in the corneal epithelium. Results: In patients with limbal deficiency without symptoms, we found that the cellular size was 477 (SD140) µm 2 and the N:C ratio was 1:5.25 (SD1.5). In patients with mild limbal deficiency, the cellular size was 764 (SD122.6) µm 2 and the N:C ratio was 1:8.2 (SD1.4). These patients did not show corneal

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“…146 Other studies have also indicated high prevalence of DED in aniridia. 74,137 Previously, the degree of ocular surface disease in aniridia was explained by low production of tears.100 Subsequently Jastaneiah and Al-Rajhi suggested that DED in these patients is related to poor tear film quality. 74 This relationship was supported by reduced tear break-up time in a high proportion of patients (80.6%).74 Moreover, stenotic meibomian gland orifices were reported in a large percentage of eyes (77.8%).…”

Section: Dry Eye Diseasementioning

confidence: 99%

Congenital aniridia – A comprehensive review of clinical features and therapeutic approaches

Landsend

Lagali

Utheim

2021

Survey of Ophthalmology

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Estudio del ojo seco en pacientes con aniridia congénita, mediante citología de impresión

Cited by 5 publications

References 0 publications

Manejo terapéutico de la queratopatía asociada a aniridia congénita

Manejo terapéutico de la queratopatía asociada a aniridia congénita

Determinación del grado de metaplasia escamosa del epitelio corneal como factor diagnóstico de insuficiencia limbal

Congenital aniridia – A comprehensive review of clinical features and therapeutic approaches

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