Estudio farmacognóstico de Werneria Apiculata y Werneria Marcida S.F. Blake

Zárate, Rosa; Gorriti, Arilmí; Lobaton, M del Carmen Santos; Jurado, Bertha

doi:10.15381/ci.v2i2.5226

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“…The parameters to be evaluated were the latency period (respiratory distress observed with the first cough) and the intensity of the effect (asphyxia due to tracheal occlusion and anaphylaxis). For this, 30 min before the experiment, the extracts and controls were administered in a single dose, after that time, all groups were subjected to nebulization of 1% histamine in an airtight chamber for 30 s at a pressure of 8 L/min (Zárate et al, 1999;Aguilar, 2015).…”

Section: Assessment Of Bronchodilator Activitymentioning

confidence: 99%

In vivo bronchodilator evaluation of the ethanolic extract of the stems of Jatropha macrantha Müll.Arg.

Chávez¹,

Palomino²,

Angelino³

et al. 2021

J Pharm Pharmacogn Res

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Context: Asthma is characterized by hyperresponsiveness and bronchoconstriction, induced by histamine and other noxes, with a prevalence in Peru of 20.7-28.2%, which is why, in traditional medicine, Jatropha macrantha Müll.Arg is used. Aims: To evaluate the in vivo bronchodilator activity of the ethanolic extract of the stems of J. macrantha. Methods: The powdered material of the stem of J. macrantha was extracted with ethanol 96° by maceration; then, the phytochemical screening was carried out. The doses of 200, 400 and 800 mg/kg of the extracts were subjected to in vivo evaluation in guinea pigs (Cavia porcellus) with 1% histamine-induced bronchoconstriction, determining the latency period and the intensity of the effect. Results: Phytochemical sieving showed alkaloids, catechins, flavonoids, tannins and terpenes. The activity was observed at the three doses of the J. macrantha extract, being higher at a single dose of 400 mg/kg, with a latency period of 33.0 ± 1.02 s, asphyxia 84.5 ± 1.08 s and anaphylaxis 105.6 ± 0.59 s. The analysis of variance and Dunnett’s test resulted with p<0.05 as statistically significant. Conclusions: The results showed bronchodilator activity of the ethanolic extract of J. macrantha at an average dose of 400 mg/kg, orally, in Cavia porcellus.

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Section: Assessment Of Bronchodilator Activitymentioning

confidence: 99%