Arsenic (As) was isolated for the first time as a chemical element by Jabir-Ibn-Haiyanb in the year 776, and its name comes etymologically from the Greek arsenicon (masculine). It is gray in color and of a shining metallic appearance, has little metallic properties, is distributed widely in the universe and its toxicity depends on the different chemical forms and states of oxidation that it has:-3, 0, +3 and +5. The historical evolution of the toxicology is intimately united to the use of this nonmetal. At present, arsenical substances are used in industry, agriculture, cattle ranching, and medicine. For that reason, the sources of exposure of man to this metal are diverse; out standing are labor, food and medicaments. In this work a revision is made of the etiology, preventive measures, analysis, diagnosis and treatment of the poisoning by As.