Estudio longitudinal del manejo renal del agua en pacientes diagnosticados de hipercalciuria idiopática en la infancia

Suárez, Germán Pérez; Serrano, Alma; Magallanes, María Victoria; Sancho, Pedro Arango; Yanes, María I. Luis; Nieto, Víctor Manuel García

doi:10.1016/j.nefro.2019.07.003

Cited by 1 publication

(1 citation statement)

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“…Inflammatory mediators such as IL-1 and TNF reduce the epithelial sodium transport due to increased PGE2 synthesis[ 51 ] and reduced expression of the epithelial sodium channel (ENaC) and/or Na + -K + -ATPase in the basolateral membrane[ 52 ]. A slight distal saline loss has been described in some adult patients, and this loss of sodium would increase urinary calcium[ 53 ]. These patients could have a triple origin for IH: bones, intestines and kidneys.…”

Section: Pathogenesis Of Hypercalciuriamentioning

confidence: 99%

Beyond kidney stones: Why pediatricians should worry about hypercalciuria

Penido¹,

Tavares²

2021

WJCP

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The incidence of urolithiasis (UL) is increasing, and it has become more common in children and adolescents over the past few decades. Hypercalciuria is the leading metabolic risk factor of pediatric UL, and it has high morbidity, with or without lithiasis as hematuria and impairment of bone mass. The reduction in bone mineral density has already been described in pediatric idiopathic hypercalciuria (IH), and the precise mechanisms of bone loss or failure to achieve adequate bone mass gain remain unknown. A current understanding is that hypercalciuria throughout life can be considered a risk of change in bone structure and low bone mass throughout life. However, it is still not entirely known whether hypercalciuria throughout life can compromise the quality of the mass. The peak bone mass is achieved by late adolescence, peaking at the end of the second decade of life. This accumulation should occur without interference in order to achieve the peak of optimal bone mass. The bone mass acquired during childhood and adolescence is a major determinant of adult bone health, and its accumulation should occur without interference. This raises the critical question of whether adult osteoporosis and the risk of fractures are initiated during childhood. Pediatricians should be aware of this pediatric problem and investigate their patients. They should have the knowledge and ability to diagnose and initially manage patients with IH, with or without UL.

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Section: Pathogenesis Of Hypercalciuriamentioning

confidence: 99%