Estudio neonatal del crecimiento intrauterino en recién nacidos chilenos de clase media 1978-1987

Background: There is limited information regarding the effects of IGF-I and/or IGFBP-3 on circulating leptin concentrations. Aim: To determine the effects of IGF-I on leptin and insulin concentrations, we examined leptin and insulin nocturnal profiles before and after the administration of the IGF-I/IGFBP-3 complex (Iplex™) to prepubertal, low birth weight children. Methods: We studied 20 prepubertal children (11 boys and 9 girls), born after a full-term pregnancy with a mean birth weight below 2.8 kg. They were studied at the mean age of 7.3 ± 0.5 years (range 4–11 years). Their mean height was –1.8 ± 0.3 SDS and their mean BMI was 0.1 ± 0.2 SDS at the time of the study. The children were studied on 2 separate occasions, the first under basal conditions, and the second time after s.c. administration of 1 mg/kg of Iplex™ at 21.00 h. Blood samples for determination of leptin and insulin were obtained every 60 min between 23.00 h and 07.00 h, while the children were sleeping. In each patient, we calculated the leptin and insulin mean area under the curve, both under basal conditions and after the administration of the IGF-I/IGFBP-3 complex. Results: Mean nocturnal leptin area under the curve exhibited a significant increase (2.7 ± 2.1 vs. 11.2 ± 2.6 ng/ml h, p < 0.05), whereas that for mean insulin showed a slight decrease, which did not reach statistical significance after administration of the IGF-I/IGFBP-3 complex. Conclusion: These findings indicate that administration of the IGF-I/IGFBP-3 complex increases circulating leptin concentrations in short prepubertal, small for gestational age children, suggesting that IGF-I and/or IGFBP-3 may stimulate leptin secretion by adipose tissue.

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Expression and Protein Content of IGF-I and IGF-I Receptor in Placentas from Small, Adequate and Large for Gestational Age Newborns

Íñiguez¹,

González²,

Argandoña³

et al. 2010

Horm Res Paediatr

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In humans, a direct relationship between IGF-I cord blood levels and birth weight has been demonstrated. To determine the placental IGF-I, IGF-II and IGF-IR mRNA and protein contents in full-term pregnancies from appropriate for gestational age (AGA), small for gestational age (SGA) and large for gestational age (LGA) newborns, we studied the placentas from 35 AGA, 30 SGA and 28 LGA pregnancies. The IGF-I, IGF-II and IGF-I receptor (IGF-IR) placental mRNA and protein contents were determined in the basal and chorionic plates of the placenta. IGF1 and IGF1R mRNA was higher in SGA compared to AGA and LGA placentas and lower in LGA compared with AGA placentas. In addition, a higher protein content of IGF-I and IGF-IR was observed in SGA compared with AGA and LGA placentas and lower contents in LGA compared with AGA placentas. These results suggest that the higher IGF-I and IGF-IR contents observed in SGA placentas and the lower contents observed in LGA placentas compared with AGA placentas may be influencing human fetal growth.

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Estudio neonatal del crecimiento intrauterino en recién nacidos chilenos de clase media 1978-1987

Cited by 3 publications

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IGF-IR/ERK content and response to IGF-I and insulin in adipocytes from small for gestational age children

IGF-IR/ERK content and response to IGF-I and insulin in adipocytes from small for gestational age children

Changes in Nocturnal Leptin and Insulin Concentrations in Prepubertal Low Birth Weight Children after Administration of the IGF-I/IGFBP-3 Complex

Expression and Protein Content of IGF-I and IGF-I Receptor in Placentas from Small, Adequate and Large for Gestational Age Newborns

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