Estudio por inmunohistoquímica de la expresión de EGFR en carcinoma de células escamosas de cabeza y cuello

Evaluation of epidermal growth factor receptor expression by a new scoring system in head-and-neck squamous cell carcinoma and its association with various pathological prognostic factors

“…as they too observed no significant association between EGFR expression and tumor stage. [ 11 25 ] Whereas our study was discordant to the study by Issa which concluded that high EGFR expression was associated with advanced tumor stage. [ 23 ] In addition, the study by Reimers et al .…”

“…Overexpression of EGFR has been observed in 40%–80% of cancers of the head and neck. [ 11 ] Similarly, our study showed high percentage of EGFR overexpression. A study conducted by Sarkis et al .…”

“…[ 21 ] However, it was seen that in the study by Reimers et al ., Altuna Mariezkurrena et al ., Issa and Hama et al ., a majority of the cases were of Grade II. [ 11 22 23 24 ]…”

“…EGFR plays an important role in numerous processes that affect cell cycle progression which leads to tumor development, growth, progression, differentiation and development of metastasis. [ 11 ] In many studies, it has been shown to correlate with a poor prognosis[ 12 13 ] and also resistance to radiotherapy in a variety of cancers, especially SCC. [ 14 ] Therefore, this study has been undertaken to evaluate the expression of EGFR in HNSCC cases and find its association with various pathological prognostic factors including grade, stage and lymph node metastasis, hoping that these findings could provide prognostic assessment of the disease and help in designing more appropriate and effective treatment strategies for OSCC.…”