Estudo cardiológico longitudinal em crianças expostas ao vírus da imunodeficiência humana tipo 1 por via perinatal

Diógenes, Maria Suely Bezerra; Succi, Regina Célia de Menezes; Machado, Daisy Maria; Moisés, Valdir Ambrósio; Novo, Neil Ferreira; Carvalho, Antônio Carlos

doi:10.1590/s0066-782x2005001700002

Cited by 12 publications

(8 citation statements)

References 47 publications

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“…É de natureza progressiva, podendo comprometer o aparelho cardiovascular de múltiplas formas. A prevalência das anormalidades cardíacas parece estar subestimada, tanto na população adulta como na infantil, com valores entre 28 e 73% (3,15) . O acometimento cardíaco na criança infectada pelo HIV-1 ocorre em torno de 50% dos casos, após aproximadamente 18 meses.…”

Section: Discussionunclassified

“…O acometimento cardíaco na criança infectada pelo HIV-1 ocorre em torno de 50% dos casos, após aproximadamente 18 meses. As manifestações clínicas mais comuns são a miocardiopatia dilatada e a insuficiência cardíaca -em torno de 12% (3,4,16) . Mesmo em pacientes assintomáticos do ponto de vista cardiovascular, 50% apresentam miocardite linfocítica intersticial nos exames anatomopatológicos.…”

Section: Discussionunclassified

“…O paciente apresentava perfusão periférica lentificada e cianose de extremidades. Os exames laboratoriais evidenciaram anemia (hemoglobina: 10,4g%; hematócrito: 33%); leucocitose (17.000 mm 3 ) com neutrofilia (59%); ureia: 47mg/dL; creatinina: 0,3mg/dL, AST: 39U/L; ALT: 28U/L; eletrólitos normais (Na: 137mmol/L; K: 5,3mmol/L; Ca: 8,9mg/dL; P: 3,1mg/dL; Mg: 2,2mg/dL); e hipoalbuminemia (2,7g/dL). Ao raio X de tórax, notou-se opacidade alvéolo/intersticial na região peri-hilar, e observaram-se base dos pulmões e cardiomegalia com índice cardiotorácico de 65% (Figura 1).…”

Section: Descrição Do Casounclassified

“…As crianças acometidas por infecção vertical têm um período clínico de latência menor e a progressão da doença é mais rápida (2) . O comprometimento cardíaco é decorrente da agressão causada pelo próprio HIV, além das infecções oportunistas, cardiotoxicidade causada pelas drogas antirretrovirais, deficiência nutricional e imunossupressão prolongada (1,(3)(4)(5)(6) . As principais manifestações cardíacas são miocardiopatia dilatada, derrame pericárdico, doença coronariana e insuficiência cardíaca congestiva (ICC) (4,7,8) .…”

Section: Introductionunclassified

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O uso da L-carnitina como adjuvante no tratamento da miocardiopatia dilatada em criança com Aids

Zanoni

Oliveira

Consolo

et al. 2011

Rev. paul. pediatr.

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ResumOObjetivo: Apresentar a resposta cardiovascular à L-carnitina de um paciente com insuficiência cardíaca congestiva decorrente de miocardiopatia dilatada pelo vírus da imunodeficiência humana.Descrição do caso: Criança com quadro clínico de insuficiência cardíaca congestiva grave devido à miocardiopatia dilatada pela síndrome de imunodeficiência adquirida. O tratamento para as manifestações clínicas foi instituído, com pouca resposta clínica. Com objetivo de melhorar o desempenho energético/ metabólico dos cardiomiócitos, foi instituída terapia com Lcarnitina. Observou-se significativa melhora clínica do paciente, em relação ao desempenho cardíaco, mesmo antes do início do tratamento com os fármacos antirretrovirais.Comentários: A L-carnitina é um composto que facilita o transporte dos ácidos graxos de cadeia longa para dentro da mitocôndria. Nesse caso, o uso da L-carnitina parece ser clinica e bioquimicamente justificado.Palavras-chave: L-carnitina; cardiomiopatia dilatada; síndrome de imunodeficiência adquirida; criança. AbstRActObjective: To present the cardiovascular response to Lcarnitine of a patient with congestive heart failure caused by dilated cardiomyopathy and human immunodeficiency virus.Case description: Child with a clinical history of severe congestive heart failure due to dilated cardiomyopathy caused by acquired immunodeficiency syndrome. The treatment for the symptoms resulted in a poor clinical response. In order to improve the energetic performance/metabolism of cardiomyocytes, therapy with L-carnitine was established. There was significant clinical improvement of the cardiac performance of the patient, even before starting the treatment with antiretroviral drugs.Comments: L-carnitine is a compound that facilitates the transport of long-chain fatty acids into the mitochondria. In this case the administration of L-carnitine appears to be clinically and biochemical justified.

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Section: Discussionunclassified

Section: Descrição Do Casounclassified

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O uso da L-carnitina como adjuvante no tratamento da miocardiopatia dilatada em criança com Aids

Zanoni

Oliveira

Consolo

et al. 2011

Rev. paul. pediatr.

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“…However, little is known about the clinical cardiac presentations in the post-HAART stage. There are reports of an increased incidence of peripheral artery diseases and coronary artery involvement in adults 6 as well as of a reduced incidence of cardiomyopathy in children [7][8][9] .…”

Section: Introductionmentioning

confidence: 99%

AIDS na infância: acometimento cardíaco com e sem a terapia anti-retroviral tríplice combinada

Cunha¹,

Filho²,

Santos³

et al. 2008

Arq. Bras. Cardiol.

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SummaryObjective: To describe the prevalence of cardiac abnormalities in the echocardiogram of children with AIDS followed up in a reference service at 18± months of AIDS confirmed diagnosis.Methods: A cross-section study with a cohort after 18± months of AIDS diagnosis. The study included a total of 93 children with a confirmed diagnosis of AIDS with vertical transmission, with no malignancies and who underwent echocardiogram (echo) during cardiologic evaluation. Cardiac abnormalities were assessed in patients who were not treated (G1) and patients who were treated (G2) with combination antiretroviral therapy.Results: When diagnosed with AIDS, the children were on average 3.07 years old and 50.50% were female. The combination regimen with antiretroviral agents was used by 47 patients (G2).

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Systematic Literature Review on the Incidence and Prevalence of Heart Failure in Children and Adolescents

Shaddy

George

Jaecklin³

et al. 2017

Pediatr Cardiol

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While the epidemiology of adult heart failure has been extensively researched, this systematic review addresses the less well characterized incidence and prevalence of pediatric HF. The search strategy used Cochrane methodology and identified 83 unique studies for inclusion. Studies were categorized according to whether the HF diagnosis was reported as primary (n = 10); associated with other cardiovascular diseases (CVDs) (n = 49); or associated with non-CVDs (n = 24). A narrative synthesis of the evidence is presented. For primary HF, the incidence ranged from 0.87/100,000 (UK and Ireland) to 7.4/100,000 (Taiwan). A prevalence of 83.3/100,000 was reported in one large population-based study from Spain. HF etiology varied across regions with lower respiratory tract infections and severe anemia predominating in lower income countries, and cardiomyopathies and congenital heart disease major causes in higher income countries. Key findings for the other categories included a prevalence of HF associated with cardiomyopathies ranging from 36.1% (Japan) to 79% (US); associated with congenital heart disease from 8% (Norway) to 82.2% (Nigeria); associated with rheumatic heart diseases from 1.5% (Turkey) to 74% (Zimbabwe); associated with renal disorders from 3.8% (India) to 24.1% (Nigeria); and associated with HIV from 1% (US) to 29.3% (Brazil). To our knowledge, this is the first systematic review of the topic and strengthens current knowledge of pediatric HF epidemiology. Although a large body of research was identified, heterogeneity in study design and diagnostic criteria limited the ability to compare regional data. Standardized definitions of pediatric HF are required to facilitate cross-regional comparisons of epidemiological data.Electronic supplementary materialThe online version of this article (10.1007/s00246-017-1787-2) contains supplementary material, which is available to authorized users.

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Estudo cardiológico longitudinal em crianças expostas ao vírus da imunodeficiência humana tipo 1 por via perinatal

Cited by 12 publications

References 47 publications

O uso da L-carnitina como adjuvante no tratamento da miocardiopatia dilatada em criança com Aids

O uso da L-carnitina como adjuvante no tratamento da miocardiopatia dilatada em criança com Aids

AIDS na infância: acometimento cardíaco com e sem a terapia anti-retroviral tríplice combinada

Systematic Literature Review on the Incidence and Prevalence of Heart Failure in Children and Adolescents

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