Estudo comparativo da capacidade funcional e qualidade de vida entre idosos com osteoartrite de joelho obesos e não obesos

Gomes‐Neto, Mansueto; Araújo, Anderson Delano; Junqueira, Isabel Dayanne Almeida; Oliveira, Diego; Brasileiro, Alécio; Arcanjo, Fabio Luciano

doi:10.1016/j.rbr.2015.05.004

Cited by 32 publications

(32 citation statements)

References 24 publications

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“…As recorded, the risk of disability caused by OA is approximately 40% in males and 47% in females, which would be higher in obese people ( 3 ). With the rapid aging of population, more and more middle-aged and elderly people are bothered by OA, seriously affecting the quality of life of patients ( 4 , 5 ). Despite the etiology of OA is very complicated and has not been clearly clarified, a variety of factors can lead to the development of OA, like joint trauma, abnormal mechanical burden, poor nutrition and genetic predisposition ( 6 , 7 ).…”

Section: Introductionmentioning

confidence: 99%

Influence of protein kinase RIPK4 expression on the apoptosis and proliferation of chondrocytes in osteoarthritis

Zou

2017

Mol Med Report

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The present study aimed to investigate the expression of receptor-interacting protein kinase 4 (RIPK4) and its effect on the apoptosis and proliferation of chondrocytes in osteoarthritis (OA). A total of 28 OA cartilage tissues and 20 normal cartilage tissues were collected to detect the expression of RIPK4 by using reverse transcription-quantitative polymerase chain reaction and western blot analysis. Chondrocytes were isolated from OA cartilage tissues and divided into OA, NC, si-RIPK4, Wnt3a, and si-RIPK4+Wnt3a groups, and those isolated from normal cartilage tissues were considered the Normal group. Chondrocytes proliferation was detected by MTT assay, cell apoptosis was indicated using flow cytometry and Wnt/β-catenin signaling pathway related-proteins were investigated using western blot analysis. RIPK4 mRNA and protein expression levels in OA cartilage tissues and OA chondrocytes were increased compared with normal controls (all P<0.05). Additionally, OA chondrocytes showed reduced cell proliferation, increased cell apoptosis and upregulated expression levels of Wnt/β-catenin signaling pathway related-proteins (all P<0.05). Once transfected with si-RIPK4, the proliferation ability of chondrocytes was enhanced, but apoptosis was notably decreased. Furthermore, the expression levels of Wnt/β-catenin signaling pathway related-proteins were significantly downregulated (all P<0.05). Results indicated that Wnt3a reversed the effect of si-RIPK4 on chondrocyte proliferation and apoptosis (all P<0.05). Thus, silencing RIPK4 promoted the proliferation and inhibited the apoptosis of chondrocytes. In addition, silencing RIPK4 blocked the Wnt/β-catenin signaling pathway, thus contributing to alleviating the OA pathogenesis.

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Section: Introductionmentioning

confidence: 99%

Influence of protein kinase RIPK4 expression on the apoptosis and proliferation of chondrocytes in osteoarthritis

Zou

2017

Mol Med Report

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“…In the National Survey on Health and Nutrition (PNSN) of 1989, approximately half (50.2%) of the elderly women evaluated were overweight, based on BMI 29 The results of linear regression analysis shown in Table 5 reveal that elderly women who were only obese had a worse 6MWT performance than elderly women with sarcopenia or who were non-obese and non-sarcopenic (β = 24.63; CI= 89.54-138.81, p=0.006). It is believed that a high BMI limits 6MWT performance, as obesity can influence gait and increase workload 31 . In our study, there was no significant difference between obese and nonobese individuals according to BMI in the 6MWT ( p=0.081).…”

Section: Discussionmentioning

confidence: 99%

Sarcopenia, nutritional status and functionality in elderly women living in the community

Neta

Souza

Câmara

et al. 2018

Rev. bras. geriatr. gerontol.

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Objective: to evaluate the relationship between sarcopenia, functional capacity and nutritional status among elderly women living in the community. Method: an observational, cross-sectional study was performed with 100 elderly women aged over 60 years. A questionnaire containing identification and socioeconomic data and information relating to the practice of physical activity was applied, while anthropometric and body composition data were measured through bioimpedance and functionality data was assessed using the six-minute walk test (6MWT). Independent t-tests were performed for the quantitative variables and analysis of variance (ANOVA) was used to compare the means of the variables. Multiple linear regression analyzes were performed to estimate the mean 6MWTfor each of the variables studied. Results: The average age of the elderly women was 67 (± 8.0) years, 41% practiced physical activity, 38% had at least an elementary school education, 48% received up to two minimum wages and 91% were obese according to waist circumference (WC). The prevalence rates for the presence of sarcopenia were: 5% for sarcopenic obesity (SO), 63% for obesity, 14% for sarcopenia and 18% had adequate weight. Elderly women who practiced physical activity, had at least an elementary education and who were non-obese according to WC, performed better in the 6MWT. There were no significant differences in the 6MWTbased on income or Body Mass Index (p>0.05). Non-obese and non-sarcopenic women walked further in the functional test than the other women (p = 0.021). Conclusion: SO was present in 5% of the elderly women and is related to poor physical performance, which was also present in elderly women with sarcopenia and obesity.

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“…Another significant result was the 20% rate of intense pain on standing up and getting in and out of a car, also described in other studies. 11 , 29 These data are of significant interest and have objective and planning repercussions: the care sector for obese patients should be located preferably on the ground floor, not requiring the use of stairs. In addition, reinforced seats should be available in a quantity compatible with the demand.…”

Section: Discussionmentioning

confidence: 99%

Radiographic evaluation and pain symptomatology of the knee in severely obese individuals – controlled transversal study

Martins

Filho²,

Raposo³

et al. 2018

Revista Brasileira de Ortopedia (English Edition)

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ObjectiveTo evaluate the prevalence of pain and radiographic degenerative arthritis in a group of severe obese patients (body mass index [BMI] > 35).Methods41 patients with an indication of bariatric surgery were studied. The group of severely obese patients was subdivided into two subgroups: those with BMI < 50 and those with BMI > 50 (n = 14). They were compared to control group (n = 39). The following parameters were analyzed and correlated: radiographic arthritis by Kellgren-Lawrence's classification, tibiofemoral axis, gender, age, and knee pain (visual analog scale [VAS]). The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) was used to evaluate in 21 severe obese patients and IN 19 controls.ResultsA higher incidence of knee pain was observed in the severely obese group when compared with the control group (p < 0.0001, odds ratio: 2.96). In the severely obese group, increasing levels of pain with aging were observed (p = 0.047). A positive correlation was observed between the incidence of radiographic arthritis and increasing age in the severely obese (p = 0.001) and control (p = 0.037) groups. The WOMAC index results were worse in the severely obese group when compared with the control group (p = 0.001, odds ratio: 18.2).ConclusionA higher incidence of knee pain was observed in the severely obese group when compared with the control group. In the severely obese group, there increasing levels of pain with aging. A positive relation between the incidence of arthritis and increasing age was observed in the severely obese and control groups. The WOMAC index results were worse in the severely obese group.

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Estudo comparativo da capacidade funcional e qualidade de vida entre idosos com osteoartrite de joelho obesos e não obesos

Abstract: OA associated with obesity caused a negative impact on functional capacity; however, quality of life scores were low, and no difference in obese and non-obese subjects was found.

Cited by 32 publications

References 24 publications

Influence of protein kinase RIPK4 expression on the apoptosis and proliferation of chondrocytes in osteoarthritis

Influence of protein kinase RIPK4 expression on the apoptosis and proliferation of chondrocytes in osteoarthritis

Sarcopenia, nutritional status and functionality in elderly women living in the community

Radiographic evaluation and pain symptomatology of the knee in severely obese individuals – controlled transversal study

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