Estudo da termodinâmica da adsorção dos enantiômeros do fármaco secnidazol

Sousa, B. B.; Cremasco, Marco Aurélio

doi:10.19146/pibic-2015-37079

Anais Do Congresso De Iniciação Científica Da Unicamp 2015

DOI: 10.19146/pibic-2015-37079

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Estudo da termodinâmica da adsorção dos enantiômeros do fármaco secnidazol

B. B. Sousa¹,

Marco Aurélio Cremasco²

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Inverse Stochastic Routine Combined to a Stepwise Modeling Approach in the Chromatographic Column Characterization Applied to Simulated Moving Bed-SMB Separation of Verapamil Enantiomers

Bihain

Silva

Oliveira

et al. 2017

DDF

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Simulated Moving Bed (SMB) chromatographic processes for the enantiomers separation of the drug verapamil were evaluated through stepwise modeling approach. Predictions of the model were compared to the dispersive equilibrium model in the simulation of continuous separation process and validated with data taken for both compounds in a SMB experimental set-up. An inverse problem tool was associated to the chromatographic columns aiming at their characterization through the global mass transfer parameters using only the experimental residence times of each enantiomer. According to the study conducted, the proposed approach was shown to be a tool with a good potential to predict the chromatographic behavior of a sample in a test pulse, as well as the simulation of separation of a compound in SMB equipment despite minor discrepancies presented in the first work cycles of the SMB. Moreover, the approach can be easily implemented and applied in the analysis of the process.

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Inverse Stochastic Routine Combined to a Stepwise Modeling Approach in the Chromatographic Column Characterization Applied to Simulated Moving Bed-SMB Separation of Verapamil Enantiomers

Bihain

Silva

Oliveira

et al. 2017

DDF

View full text Add to dashboard Cite

show abstract

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Estudo da termodinâmica da adsorção dos enantiômeros do fármaco secnidazol

Cited by 1 publication

References 0 publications

Inverse Stochastic Routine Combined to a Stepwise Modeling Approach in the Chromatographic Column Characterization Applied to Simulated Moving Bed-SMB Separation of Verapamil Enantiomers

Inverse Stochastic Routine Combined to a Stepwise Modeling Approach in the Chromatographic Column Characterization Applied to Simulated Moving Bed-SMB Separation of Verapamil Enantiomers

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