Estudo de melanoma da coróide no Hospital Regional de São José - Santa Catarina

Júnior, Astor Grumann; Neto, Augusto Adam; Lima, Gina Carriero; Vergini, Franciele; Souza, Thiago de

doi:10.1590/s0004-27492006000400017

Arq. Bras. Oftalmol.

2006

DOI: 10.1590/s0004-27492006000400017

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Estudo de melanoma da coróide no Hospital Regional de São José - Santa Catarina

Astor Grumann Júnior¹,

Augusto Adam Neto²,

Gina Carriero Lima³

et al.

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Cited by 3 publications

References 12 publications

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Molecular and immunohistochemical analyses of uveal melanoma patient cohort

Hc¹,

Pereira²,

Gomes³

et al. 2019

Melanoma Research

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Uveal melanoma is a rare form of melanoma and the most frequent primary eye malignancy in adults. The major molecular alterations underlying uveal melanoma pathogenesis affect mainly the GNAQ, GNA11, SF3B1, and BAP1 genes. In this study, we somatically genotyped 31 Brazilian uveal melanomas for BRAF, GNA11, GNAQ, SF3B1, and BAP1 gene mutations and assessed BRCA2 and p53 protein expression. GNAQ and GNA11 mutations were detected in 60%, and SF3B1 mutation rate was 30%. p53 Immunostaining was markedly positive in 5/31, and 3/31 samples showed negative BRCA2 expression. This study supports the importance of these key genes in uveal melanoma tumorigenesis; p53 and BRCA pathways seem to play a role in a subset of patients, possibly heralding unfavorable prognosis.

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Molecular and immunohistochemical analyses of uveal melanoma patient cohort

Hc¹,

Pereira²,

Gomes³

et al. 2019

Melanoma Research

View full text Add to dashboard Cite

show abstract

Evidências obtidas de um caso de melanoma de íris recidivado

Ferreira¹,

Rolim²,

Leite³

et al. 2009

Rev. bras.oftalmol.

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RESUMOO artigo apresenta uma análise histológica de um caso de melanoma recidivado de íris após sete meses da iridociclectomia, em uma paciente de 45 anos. Após enucleação, o exame histopatológico do globo ocular demonstrou a persistência de um pequeno fragmento do tumor no coto da íris remanescente, evoluindo para recorrência da neoplasia. O caso traz dados para uma discussão sobre a cirurgia conservadora de melanomas oculares, visando uma postura analítica dentro do espírito da Medicina Baseada em Evidência. Um caso raro, com documentação apenas do ponto de vista histopatológico, que motiva a utilização destes achados na discussão do assunto. A não contiguidade do que restou do tumor com as tumorações da recidiva fala em favor da disseminação e proliferação de células neoplásicas nas cirurgias conservadoras.

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Perfil dos pacientes submetidos à reconstrução primária da cavidade orbitária com implante de Mules após enucleação e evisceração

Branco¹,

Júnior²

2012

Rev. bras.oftalmol.

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Estudo de melanoma da coróide no Hospital Regional de São José - Santa Catarina

Cited by 3 publications

References 12 publications

Molecular and immunohistochemical analyses of uveal melanoma patient cohort

Molecular and immunohistochemical analyses of uveal melanoma patient cohort

Evidências obtidas de um caso de melanoma de íris recidivado

Perfil dos pacientes submetidos à reconstrução primária da cavidade orbitária com implante de Mules após enucleação e evisceração

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