Estudo experimental da aplicação retiniana do laser infravermelho via transescleral sob condições de baixa visibilidade

Goulart, Dario Grechi; Sano, Ronaldo Yuti; Cursino, Sylvia Regina Temer; Takahashi, Walter Yukihiko

doi:10.1590/s0004-27492008000300007

Cited by 2 publications

(2 citation statements)

References 8 publications

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“…Even if OCT and laser retinopexy were performed by the same person, a board-certified veterinary ophthalmologist with experience in this procedure, perhaps an incomplete laser retinopexy probe application on the scleral surface might prevent the production of a complete retinal lesion. Previous literature also reports that the absorption of energy in the sclera and pigments in the choroid could function, at least theoretically, as a barrier to the passage of the intraretinal diode laser toward the retina [ 3 ]. The small number of photocoagulation lesions did not allow for a severity score-based statistical analysis of the photocoagulation lesions.…”

Section: Discussionmentioning

confidence: 99%

“…Retinal detachment (RD) occurs due to separation in the neurosensory retina from the underlying retinal pigmented epithelium (RPE) [ 1 ]. Transscleral retinopexy prevents RD by anchoring the retina to the choroid, even in cases with poor retinal visualization [ 2 , 3 ]. However, to the best of the authors’ knowledge, the progression of retinal changes following transscleral retinopexy has not been described using medical imaging [ 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

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Morphological Evaluation of Transscleral Laser Retinopexy in Rabbits: Comparison of Optical Coherence Tomography and Histologic Examinations

Vanore,

Juette,

Benito

et al. 2023

Veterinary Sciences

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Transscleral retinopexy is a preventive technique used against retinal detachment. Fundus examination can allow the monitoring of morphological retinal changes in the progression of photocoagulation lesions, without offering details on the morphological changes by the retinal lesion. The aim of the study was to assess the progression of photocoagulation lesions induced by transscleral retinopexy (840 nm diode laser), by comparing the optical coherence tomography (OCT) and histological images over a period of six weeks on eight pigmented New Zealand healthy rabbits (four males and four females; n = 16 eyes). All rabbits underwent transscleral retinopexy on their left eye on day 0 (D0). Measurements of the photocoagulation lesions were obtained in vivo on D0, D7, D15, D21, and D42 by acquiring OCT images of both eyes from all rabbits. On D1, D7, D21, and D42, two rabbits were euthanized, and their eyes were enucleated. A significant effect by time on the decrease in the central retinal thickness of the photocoagulation lesion was observed from D1 to D7 (p = 0.001); however, no such effect was observed on the horizontal length ((HL) p = 0.584) of the lesion surface. The reliability between the OCT and histological measurements, which were evaluated using intraclass correlation coefficients, was excellent for measuring the retinal thickness at the center (ICC = 0.91, p < 0.001), moderate for the right side of the retinal lesions (ICC = 0.72, p = 0.006), and not significant for the left side and HL (p = 0.055 and 0.500, respectively). The morphological changes observed in the OCT and histopathological images of the photocoagulation lesions were qualitatively described over time. OCT is an effective tool for monitoring changes in photocoagulation lesions. Some measurements and qualitative changes showed an adequate correlation between the OCT and histological findings.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Morphological Evaluation of Transscleral Laser Retinopexy in Rabbits: Comparison of Optical Coherence Tomography and Histologic Examinations

Vanore,

Juette,

Benito

et al. 2023

Veterinary Sciences

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Nanocarriers in Ocular Drug Delivery: An Update Review

Wadhwa¹,

Paliwal²,

Paliwal³

et al. 2009

CPD

173

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Controlled drug delivery to eye is one of the most challenging fields of pharmaceutical research. Low drug-contact time and poor ocular bioavailability due to drainage of solution, tear turnover and its dilution or lacrimation are the problems associated with conventional systems. In addition, anatomical barriers and physiological conditions of eye are also important parameters which control designing of drug delivery systems. Nanosized carriers like micro/nano-suspensions, liposome, niosome, dendrimer, nanoparticles, ocular inserts, implants, hydrogels and prodrug approaches have been developed for this purpose. These novel systems offer manifold advantages over conventional systems as they increase the efficiency of drug delivery by improving the release profile and also reduce drug toxicity. Conventional delivery systems get diluted with tear, washed away through the lacrimal gland and usually require administering at regular time intervals whereas nanocarriers release drug at constant rate for a prolonged period of time and thus enhance its absorption and site specific delivery. This review presents an overview of the various aspects of the ocular drug delivery, with special emphasis on nanocarrier based strategies, including structure of eye, its barriers, delivery routes and the challenges/limitations associated with development of novel nanocarriers. The recent progresses in therapy of ocular disease like gene therapy have also been included so that future options should also be considered from the delivery point of view. Recent progress in the delivery of proteins and peptides via ocular route has also been incorporated for reader benefit.

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Estudo experimental da aplicação retiniana do laser infravermelho via transescleral sob condições de baixa visibilidade

Cited by 2 publications

References 8 publications

Morphological Evaluation of Transscleral Laser Retinopexy in Rabbits: Comparison of Optical Coherence Tomography and Histologic Examinations

Morphological Evaluation of Transscleral Laser Retinopexy in Rabbits: Comparison of Optical Coherence Tomography and Histologic Examinations

Nanocarriers in Ocular Drug Delivery: An Update Review

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