Estudo histopatológico do trajeto de biópsia de tumores musculoesqueléticos malignos

Ribeiro, Marcelo Barbosa; Oliveira, Cláudia de; Filippi, Renée Zon; Baptista, André Mathias; Caiero, Marcelo Tadeu; Saito, Carlos Fernando; Nascimento, Sérgio Antonio Barbosa do; Camargo, Olavo Pires de

doi:10.1590/s1413-78522009000500005

Cited by 12 publications

(28 citation statements)

References 9 publications

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“…Another empirically widespread issue is that the percutaneous biopsy technique, by involving less manipulation of the tumor tissue, also implies a lower contamination of the biopsy tract 4 7 , 16 - 18 It has also been observed that the contamination of the biopsy path is more frequent in soft tissue sarcomas than in cartilaginous and osseous lesions 13 . it is also believed that neoadjuvant chemotherapy has a protective effect in the control of tumor infiltration in the biopsy site, 17 , 19 and that this contamination has a negative value in the prognosis of affected patients 20 …”

Section: Introductionmentioning

confidence: 99%

Neoplasm seeding in biopsy tract of the musculoskeletal system. A systematic review

et al. 2014

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To identify, through a systematic literature review, the characteristics of neoplasm seeding in biopsy performed on the musculoskeletal system. We performed a search on PubMed, MEDLINE, LILACS and SciELO from August to October 2010. We included articles that addressed the neoplasm seeding in biopsy performed on the musculoskeletal system. The search was limited to English, Spanish and Portuguese as publication languages, but it was not limited by year of publication. We retrieved 2858 articles, but only seven were selected based on inclusion and exclusion criteria. Other four papers were found in the references of selected articles, totalizing 11 articles that were used to perform this systematic review. Issues may be raised in the literature: age and gender don't seem to influence the occurrence of neoplasm seeding; without resection of the biopsy tract, the possibility of local recurrence is very real; the influence of the type of tumor in the occurrence of neoplasm seeding is uncertain; it is impossible to conclude whether the closed biopsy technique has a lower chance of neoplasm seeding; it is likely that adjuvant chemotherapy has a protective effect against neoplasm seeding; an unfavorable prognosis is expected according to neoplasm seeding results.

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Section: Introductionmentioning

confidence: 99%

Neoplasm seeding in biopsy tract of the musculoskeletal system. A systematic review

et al. 2014

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“…Ribeiro et al (17) , who studied both bone and soft-tissue tumors, found four cases of contamination (57.1%) among seven cases of soft-tissue tumors and four cases of contamination (22.2%) among 18 cases of bone tumors. These authors suggested that greater cellularity and lower quantities of matrix, which are particular characteristics of soft-tissue sarcomas, would be related to greater cell dissemination, in comparison with bone tumors.…”

Section: Discussionmentioning

confidence: 97%

“…Another issue raised in the literature is the influence of the type of tumor on occurrences of tumor contamination in the biopsy path (17,29) . Ribeiro et al (17) , who studied both bone and soft-tissue tumors, found four cases of contamination (57.1%) among seven cases of soft-tissue tumors and four cases of contamination (22.2%) among 18 cases of bone tumors.…”

Section: Discussionmentioning

confidence: 99%

“…The Many surgeons with experience in treating musculoskeletal tumors advocate removal of the biopsy path at the time of surgically resecting the tumor, taking the view that this path is potentially contaminated by tumor cells (5,6,(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18) . However, no basis for this practice has been found in any scientific studies, and it is based more on personal experience than on the current literature.…”

Section: Introductionmentioning

confidence: 99%

“…It is also believed that implementing neoadjuvant chemotherapy has a protective effect with regard to controlling tumor infiltration at the biopsy site (20,22) and that this contamination has a negative value in the prognosis for affected patients (23) . In the literature, there is a lack of detailed studies on biopsy paths in cases of musculoskeletal tumors (17,20,21) . Knowledge of the characteristics of contamination of biopsy paths within orthopedic oncology may provide important support for improving biopsy techniques and for following up patients affected by these tumors.…”

Section: Introductionmentioning

confidence: 99%

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Contaminação tumoral em trajeto de biópsia de tumores ósseos malignos primários

Oliveira¹,

Lima²,

Mello³

2012

Rev. bras. ortop.

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Objective: To study factors possibly associated with tumor contamination in the biopsy path of primary malignant bone tumors. Method: Thirty-five patients who underwent surgical treatment with diagnoses of osteosarcoma, Ewing's tumor and chondrosarcoma were studied retrospectively. The sample was analyzed to characterize the biopsy technique used, histological type of the tumor, neoadjuvant chemotherapy used, local recurrences and tumor contamination in the biopsy path. Results: Among the 35 patients studied, four cases of contamination occurred (11.43%): one from osteosarcoma, two from Ewing's tumor and one from chondrosarcoma. There was no association between the type of tumor and presence of tumor contamination in the biopsy path (p = 0.65). There was also no association between the presence of tumor conRev Bras Ortop. 2012;47(5):631-7The authors declare that there was no conflict of interest in conducting this work This article is available online in Portuguese and English at the websites: www.rbo.org.br and www.scielo.br/rbort tamination and the biopsy technique (p = 0.06). On the other hand, there were associations between the presence of tumor contamination and local recurrence (p = 0.01) and between tumor contamination and absence of neoadjuvant chemotherapy (p = 0.02). Conclusion: Tumor contamination in the biopsy path of primary malignant bone tumors was associated with local recurrence. On the other hand, the histological type of the tumor and the type of biopsy did not have an influence on tumor contamination. Neoadjuvant chemotherapy had a protective effect against this complication. Despite these findings, tumor contamination is a complication that should always be taken into consideration, and removal of the biopsy path is recommended in tumor resection surgery.

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Needle tract seeding after percutaneous biopsy of sarcoma: Risk/benefit considerations

Berger-Richardson

Swallow

2016

Cancer

126

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To evaluate histologic subtype and grade, which in turn guide the decision making for multimodality therapy, the workup of suspected sarcoma requires more material than can be obtained from a fine-needle aspiration. Either open or percutaneous core needle biopsy is indicated before a management decision is made. Percutaneous biopsy of a potentially malignant lesion is controversial, given the perceived potential for tumor seeding along the needle tract. However, the evidence that the latter is a significant risk is weak at best. To the authors' knowledge, among cases of patients with extremity sarcoma who have undergone core needle biopsy, only a few cases of needle tract seeding have been reported to date. Although en bloc excision of the needle tract with the primary tumor is often performed, this practice is not associated with improved oncologic outcomes; the evidence for excision of the needle tract is poor. For patients with gastrointestinal stromal tumors, there is a theoretical risk of peritoneal dissemination after percutaneous biopsy, but to the authors' knowledge this remains unproven. Although endoscopic ultrasound is the preferred route for biopsy among patients with gastrointestinal stromal tumors, percutaneous biopsy is indicated if endoscopic ultrasound is unsuitable or unavailable. In the setting of retroperitoneal sarcoma, a review of pooled data from 4 large tertiary care referral centers demonstrated a risk of needle tract seeding of 0.37%. The authors concluded that the benefits of pretreatment biopsy in patients with mesenchymal tumors outweigh the potential risks of needle tract seeding. Cancer 2017;123:560-567. © 2016 American Cancer Society.

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Estudo histopatológico do trajeto de biópsia de tumores musculoesqueléticos malignos

Cited by 12 publications

References 9 publications

Neoplasm seeding in biopsy tract of the musculoskeletal system. A systematic review

Neoplasm seeding in biopsy tract of the musculoskeletal system. A systematic review

Contaminação tumoral em trajeto de biópsia de tumores ósseos malignos primários

Needle tract seeding after percutaneous biopsy of sarcoma: Risk/benefit considerations

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