Estudo morfométrico do fígado de ratos submetidos a doses supra-fisiológicas de tiroxina

Engelman, Míriam F.B.; Neto, João Guidugli; Andrade, Carlos H.V.; Hernández, Rosana; Goulart, Lúcia B.N.T.

doi:10.1590/s0004-27302001000200009

Cited by 20 publications

(16 citation statements)

References 27 publications

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“…Considering that cholestasis involves bile ducts, significant changes found in our study might indicate that administration of TP altered the concentration of bile ducts conveyed by said. Moreover, it might have an increase in the volume of capillaries sinusoids by a hepatic congestion (Engelman et al, 2001). Bento-Silva et al (2010) described the occurrence of hepatic congestion in rats that received administration testosterone undecanoate.…”

Section: Discussionmentioning

confidence: 99%

Use of Anabolic Steroid Altered the Liver Morphology of Rats

et al. 2014

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TANASOV, V. S.; NETO, W. K.; GONÇALVES, L.; MAIFRINO, L. B. M.; DE SOUSA, R. R. & GAMA, E. F. Use of anabolic steroid altered the liver morphology of rats. Int. J. Morphol., 32(3):756-760, 2014. SUMMARY:The aim of this research was to investigate the effect of testosterone propionate administration in the liver of rats. The rats were divided in the following groups: Initial control (SC), Aged control (SE) and Anabolic group (SA). Testosterone propionate was administered three times per week during 16 weeks. Using morphoquantitative techniques, we quantified the volume densities of lobular and non-lobular parenchyma, area and number of nuclei of hepatocytes. The data were analyzed statistically using mean and standard deviation, ANOVA one-way and level of significance about p≤0.05. Our results showed an increase in capillaries, perisinusoidal spaces and biliary ducts in SE group compared to SC. SA group showed a decrease in hepatic cells, non-lobular volume density and hepatocytes nuclei area, but also an increase in capillaries, perisinusoidal spaces, biliary ducts, number of hepatocytes and non-hepatocyte nuclei compared to SC. We conclude that a direct toxicity may have occurred, with consequent loss of the cells.

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Section: Discussionmentioning

confidence: 99%

Use of Anabolic Steroid Altered the Liver Morphology of Rats

et al. 2014

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“…Rodents have been increasingly used in this kind of study, once they are prospective regarding the action of chemicals in humans. Furthermore, the organs that are considered vital are good histological biomarkers in toxicity assays [24].…”

Section: Doi: 107243/2055-091x-4-9mentioning

confidence: 99%

“…The histological analysis showed that the hepatic tissue of the individuals belonging to the three control groups was intact, with preserved hepatocytes, arranged in cords and permeated by Kupffer cells, also intact [21,24].…”

Section: Livermentioning

confidence: 99%

“…Another relatively frequent alteration observed was the hypertrophy of the hepatocyte, which could be directly associated with the metabolism increase and the protein synthesis in these cells, stimulated by the release of thyroid hormones, once a histopathologic alteration in the thyroid of the individuals exposed was also detected in this study. Hepatotoxicity studies in rats subjected to supraphysiological doses of thyroxine, reported hypertrophic hepatocytes resulting from the action of thyroid hormones [24].…”

Section: Livermentioning

confidence: 99%

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Histopathological changes in the liver and thyroid of mice (Mus musculus) caused by the acaricides: fipronil and thymol

Cunha¹,

Matos²,

Pereira³

et al. 2017

J Histol Histopathol

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The control of tick Rhipicephalus (Boophilus) microplus, that has the cattle as preferential host, has been performed using products based on different chemical substances. However, the indiscriminate use of these products has caused the selection of resistant populations and damages to the environment, contaminating the soil and water. Tickcides, like fipronil (synthetic chemical) and thymol (natural chemical), are applied on cattle through aspersion, causing the death of the ectoparasites. Nevertheless, the effects of these products on nontarget organisms have not been thoroughly investigated. Thus, this study evaluated the morphology of the liver and thyroid of female Mus musculus mice, divided into 5 treatment groups/5 individuals each, exposed to fipronil (2%) and thymol (2 mg/mL) through aspersion baths. After exposure, the mice were euthanized with anaesthetic overdose and dissected for organ removal. The results showed that both fipronil and thymol caused morphological alterations in the organs: cytoplasmic vacuolation, cell death characteristics in hepatocyte nuclei and structural disorganization of the thyroid gland. Along with body weight measurement, the results suggest that the morphological alterations would be a systemic response of the organism to the toxic action of these products, regardless their origin (synthetic of natural).

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“…Alterações crônicas no fígado podem estar presentes e variam de fibrose portal leve até cirrose e redução da glutationa, com aumento de radicais reativos de oxigênio. 7,8,9 Nem sempre as alterações supracitadas são diagnosticadas pela ultrassonografia abdominal, não sendo possível descartar uma hepatopatia difusa quando o órgão apresenta-se normal ao exame, uma vez que se pode não ocorrer distorção da textura ou da arquitetura interna do parênquima. 10,11 O acúmulo de gordura promove maior reflexão das ondas sonoras elevando a ecogenicidade do parênquima hepático em relação ao ligamento falciforme.…”

Section: Introductionunclassified

Ultrassonografia quantitativa do fígado em gatos com tirotoxicose induzida

Santos

Monteiro

Oliveira

et al. 2009

Braz. J. Vet. Res. Anim. Sci.

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Este estudo avaliou ultrassonograficamente o fígado de gatos submetidos à tirotoxicose induzida pela técnica de histograma dos níveis de cinza com o objetivo de melhor avaliar possíveis alterações hepáticas decorrentes do excesso de hormônios tiroidianos. Para isto, foram utilizados nove gatos hígidos, adulto-jovens, que receberam diariamente 150µg/kg de levotiroxina sódica, por 60 dias. O histograma hepático não demonstrou diferença estatística ao nível de 5% de significância entre os momentos avaliados; entretanto, as variações dos valores das variáveis estudadas sugeriram a promoção de aumento da heterogeneidade e diminuição da ecogenicidade do parênquima hepático quando comparado ao momento inicial. A avaliação citopatológica e histopatológica revelou quadro de hepatite tirotóxica em todos os animais.

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Estudo morfométrico do fígado de ratos submetidos a doses supra-fisiológicas de tiroxina

Cited by 20 publications

References 27 publications

Use of Anabolic Steroid Altered the Liver Morphology of Rats

Use of Anabolic Steroid Altered the Liver Morphology of Rats

Histopathological changes in the liver and thyroid of mice (Mus musculus) caused by the acaricides: fipronil and thymol

Ultrassonografia quantitativa do fígado em gatos com tirotoxicose induzida

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