Estudo prospectivo das complicações da Doença de Kawasaki: análise de 115 casos

Alves, Natália Ribeiro de Magalhães; Magalhães, Cristina Medeiros Ribeiro de; Almeida, Roseane de Fátima R.; Santos, Rosa Maria Nascimento dos; Gandolfi, Lenora; Pratesi, Riccardo

doi:10.1590/s0104-42302011000300012

Cited by 32 publications

(48 citation statements)

References 38 publications

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“…The clinical presentation is characterized by prolonged fever, polymorphous skin rash, nonpurulent conjunctival injection, extremity changes, oral mucosal changes, and cervical lymphadenopathy. The CNS involvement occurs in about 0.4% of children in the form of aseptic meningitis, meningoencephalitis, hypoperfused brain, ischemia, cerebral and cerebellar infarction, and subdural effusion [18, 19]. In the case of aseptic meningitis we must distinguish two different forms, first one being secondary to the disease and second one following IVIG administration [20].…”

Section: Kawasaki Diseasementioning

confidence: 99%

Recent Understanding on Diagnosis and Management of Central Nervous System Vasculitis in Children

Iannetti

Zito

Bruschi

et al. 2012

Clinical and Developmental Immunology

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Central nervous system vasculitides in children may develop as a primary condition or secondary to an underlying systemic disease. Many vasculitides affect both adults and children, while some others occur almost exclusively in childhood. Patients usually present with systemic symptoms with single or multiorgan dysfunction. The involvement of central nervous system in childhood is not frequent and it occurs more often as a feature of subtypes like childhood polyarteritis nodosa, Kawasaki disease, Henoch Schönlein purpura, and Bechet disease. Primary angiitis of the central nervous system of childhood is a reversible cause of severe neurological impairment, including acute ischemic stroke, intractable seizures, and cognitive decline. The first line therapy of CNS vasculitides is mainly based on corticosteroids and immunosuppressor drugs. Other strategies include plasmapheresis, immunoglobulins, and biologic drugs. This paper discusses on current understanding of most frequent primary and secondary central nervous system vasculitides in children including a tailored-diagnostic approach and new evidence regarding treatment.

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Section: Kawasaki Diseasementioning

confidence: 99%

Recent Understanding on Diagnosis and Management of Central Nervous System Vasculitis in Children

Iannetti

Zito

Bruschi

et al. 2012

Clinical and Developmental Immunology

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“…Knott, et al [5] found that 19 of 62 patients experienced SNHL with KD. Similarly, in the most recent and largest study of 115 KD patients by Alves, et al, [7] 33% had SNHL during the acute and subacute phases of the disease. In the present case, the patient's parents failed to identify the hearing problem early after discharge and brought him to our clinic 4 days later, when he failed to correctly recognize words, even when hearing his own speech.…”

Section: Discussionmentioning

confidence: 80%

Kawasaki Disease and Labyrinthitis: An Underdiagnosed Complication

Kim

Park

et al. 2017

J Audiol Otol

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Sensorineural hearing loss (SNHL) that is seldom cited as a Kawasaki disease (KD) complication is known as an additional, potentially severe, and frequently irreversible sequel. Furthermore the vestibular functions of KD have been underestimated and it could be an important complication combined with SNHL in KD. We described a case that a 4 year-old boy who developed vestibular loss with SNHL has recovered successfully with a combined treatment.

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“…KD is known to be associated with lesion of small-to-medium size arteries in most of the patients. But thoracic aortic aneurysms as the complication of KD are reported in 0.9% of patients with KD30) and aortic root dilatations are reported in 8% of patients with KD31). Also, there is another report that a 33 years-old man suffered from incomplete KD had a coronary artery bypass surgery because of the multiple-vessel coronary artery disease.…”

Section: Discussionmentioning

confidence: 99%

Transforming growth factor beta receptor II polymorphisms are associated with Kawasaki disease

et al. 2012

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PurposeTransforming growth factor beta receptor 2 (TGFBR2) is a tumor suppressor gene that plays a role in the differentiation of striated cells and remodeling of coronary arteries. Single nucleotide polymorphisms (SNPs) of this gene are associated with Marfan syndrome and sudden death in patients with coronary artery disease. Cardiovascular remodeling and T cell activation of TGFBR2 gene suggest that the TGFBR2 gene SNPs are related to the pathogenesis of Kawasaki disease (KD) and coronary artery lesion (CAL).MethodsThe subjects were 105 patients with KD and 500 healthy adults as controls. Mean age of KD group was 32 months age and 26.6% of those had CAL. We selected TGFBR2 gene SNPs from serum and performed direct sequencing.ResultsThe sequences of the eleven SNPs in the TGFBR2 gene were compared between the KD group and controls. Three SNPs (rs1495592, rs6550004, rs795430) were associated with development of KD (P=0.019, P=0.026, P=0.016, respectively). One SNP (rs1495592) was associated with CAL in KD group (P=0.022).ConclusionEleven SNPs in TGFBR2 gene were identified at that time the genome wide association. But, with the change of the data base, only six SNPs remained associated with the TGFBR2 gene. One of the six SNPs (rs6550004) was associated with development of KD. One SNP associated with CAL (rs1495592) was disassociated from the TGFBR2 gene. The other five SNPs were not functionally identified, but these SNPs are notable because the data base is changing. Further studies involving larger group of patients with KD are needed.

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Estudo prospectivo das complicações da Doença de Kawasaki: análise de 115 casos

Cited by 32 publications

References 38 publications

Recent Understanding on Diagnosis and Management of Central Nervous System Vasculitis in Children

Recent Understanding on Diagnosis and Management of Central Nervous System Vasculitis in Children

Kawasaki Disease and Labyrinthitis: An Underdiagnosed Complication

Transforming growth factor beta receptor II polymorphisms are associated with Kawasaki disease

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