Estudo toxicológico agudo do extrato etanólico de partes aéreas de Jatropha gossypiifolia L. em ratos

Chronic toxicologic study of the ethanolic extract of the aerial parts of Jatropha gossypiifolia in rats

“…In the evaluation of the animals' motor activity, through the Rota Rod, the only relevant alteration was the reduction (54.5% in relation to the control) of the time of permanence, of females (405 mg/kg) during the third experimental week (Figure 2). These results confirm the signs of activity reduction of CNS, including the decrease of locomotor function already reported during -the evaluation of the acute toxicity of the extract (Mariz et al, 2006). A sign of hyperglycemic potential was also observed.…”

“…In the animals treated with 135 mg/kg and, more intensely, in those treated with 405 mg/kg, besides the effects mentioned before, it was observed: prostration, abdominal contortions; increase in evacuation; dyspnea; moderate eyelid ptosis and hindlimb paralysis, a sign which is associated with gradual weight loss and starvation, were previous characteristics of death. These effects had already been reported previously during the acute exposition of rats to high doses of ethanolic extracts of J. gossypiifolia and seem to confirm the signs of reduction of CNS activity and gastrointestinal disturbances (Mariz et al, 2006).…”

“…It becomes clear that the changes in these parameters cannot be considered the only ones responsible for the changes in the weight evolution, considering that, during most part of the treatment, there was no correspondence between the alteration of gain and weight loss and those observed in the consumption of food and water. That is, other metabolic parameters must have been affected by the extract, mainly in males treated with the higher dose, where the significant weight loss corroborates the findings of the acute study (Mariz et al, 2006).…”

“…In recent publications, we showed that the ethanolic extract of aerial parts (leaves and stem) of this species produced a relatively low oral acute toxicity in rats, though pointing out that the signs of hepatic, renal and pulmonary toxicity should be better evaluated through chronic toxicological studies (Mariz et al, 2006;Mariz et al, 2008).…”

Avaliação histopatológica em ratos após tratamento agudo com o extrato etanólico de partes aéreas de Jatropha gossypiifolia L.

“…Apesar de o extrato ter produzido mortalidade entre machos tratados com as doses de 4 g/kg (16,6%) e 5 g/kg (66,6%) e do 3º ao 10º dia após o tratamento, o exame macroscópico das vísceras permitiu observar-se alterações apenas em alguns órgãos dos animais tratados com a maior dose experimental (5 g/kg) e que morreram ao longo do experimento (machos). Tais alterações se constituíram em mudanças na coloração e consistência de coração, pulmão e fígado, fato que já ressaltava a importância da realização de exames histopatológicos para uma melhor avaliação do potencial infl amatório e necrosante do produto (Mariz et al, 2006). O presente trabalho apresenta um estudo histopatológico de vísceras de ratos após tratamento agudo com o produto avaliado, realizado não apenas para atender as exigências da resolução № 90 da Agência Nacional de Vigilância Sanitária (Brasil, 2004), mas, principalmente, com o intuito de investigar a capacidade do extrato em produzir alterações histológicas em fígado, pulmão, rins e coração destes animais.…”