Estudos de associação genética no transtorno obsessivo-compulsivo

Sampaio, Aline Santos; Lins, Rita Márcia Pacheco; Daltro-Oliveira, Renato; Quarantini, Lucas de Castro; Rosário, Maria Conceição do; Miguel, Eurí­pedes Constantino; Hounie, Ana Gabriela

doi:10.1590/s0101-60832013000500003

Cited by 9 publications

(11 citation statements)

References 163 publications

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“…Although the mechanisms of altered WM microstructure in OCD are far from clear, a number of lines of research 35,36 and prior genetic association studies have described specific genes related to myelination 37 , while there is evidence that genetic variants related to glutamatergic, dopaminergic, and neurodevelopmental pathways determine WM microstructure in children and adolescents with OCD 38 . Although no genes related to myelination have yet reached genome wide-significance, given preliminary findings from small samples, it is possible that such significance will be reached with better powered GWASs.…”

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confidence: 99%

White Matter Microstructure and its Relation to Clinical Features of Obsessive-Compulsive Disorder: Findings from the ENIGMA OCD Working Group

Piras¹,

Piras²,

Abe

et al. 2019

Preprint

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KEY POINTSQuestion: Do patients with Obsessive-Compulsive Disorder (OCD) show white matter microstructural alterations, and are these alterations related to clinical features?Findings: Data from 19 sites of the ENIGMA-OCD Consortium were included, involving 700 adult patients and 645 adult controls, 174 pediatric patients and 144 pediatric controls. Diffusion tensor imaging data were meta-analyzed using a harmonized data processing and analysis protocol. Adult, but not pediatric, 6 patients showed alterations in the sagittal stratum and posterior thalamic radiation; sagittal stratum differences were associated with clinical features.Meaning: Microstructural abnormalities found in adult but not in the pediatric cohort, are related to illness duration and medication status. 7 ABSTRACT Importance: Microstructural alterations in cortico-subcortical connections are thought to be present in Obsessive-Compulsive Disorder (OCD). However, prior studies have yielded inconsistent findings, perhaps because small sample sizes provided insufficient power to detect subtle abnormalities. Objective: To investigate microstructural white matter alterations and their relation to clinical features in the largest dataset of adult and pediatric OCD to date. Design, Setting, and Participants: In this cross-sectional case-control magnetic resonance study, we investigated diffusion tensor imaging metrics from 700 adult patients and 645 adult controls, as well as 174 pediatric patients and 144 pediatric controls across 19 sites participating in the ENIGMA-OCD Working Group. Main Outcomes and Measures:We extracted measures of fractional anisotropy (FA) as main outcome, and mean diffusivity, radial diffusivity, and axial diffusivity as secondary outcomes for 25 white matter regions. We meta-analyzed patient-control group differences (Cohen's d) across sites, after adjusting for age and sex, and investigated associations with clinical characteristics.Results: Adult OCD patients showed significant FA reduction in the sagittal stratum (d=-0.21, z=-3.21, p=0.001) and posterior thalamic radiation (d=-0.26, z=-4.57, p<0.0001). In the sagittal stratum only, lower FA was associated with a younger age of onset (z=2.71, p=0.006), longer duration of illness (z=-2.086, p=0.036) and a higher percentage of medicated patients in the cohorts studied (z=-1.98, p=0.047). No significant association with

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confidence: 99%

White Matter Microstructure and its Relation to Clinical Features of Obsessive-Compulsive Disorder: Findings from the ENIGMA OCD Working Group

Piras¹,

Piras²,

Abe

et al. 2019

Preprint

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“…Segundo Sampaio et al (2013), se a frequência dos probandos estudados for significativamente maior que dos indivíduos portadores dessa doença, pode-se afirmar que ela apresenta um caráter familial.…”

Section: Resultados E Discussõesunclassified

Transtorno Obsessivo-Compulsivo: Aspectos Genéticos E O Tratamento Com Base Na Terapia Cognitivo-Comportamental

Araujo¹,

Gomes²,

Neto³

et al. 2019

A Pesquisa Em Psicologia Em Foco

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“…Dados de 28 estudos de gêmeos no TOC têm mostrado convincentemente que os sintomas obsessivo-compulsivo (SOC) são hereditários, com contribuições genéticas médias de 45% a 65% em crianças e de 27% a 47% em adultos (SAMPAIO et al, 2013). c. Estudos de Segregação nos casos de TOC Gonzalez (1999), concluiu que o modelo de transmissão mais compatível seria o autossômico dominante com penetrância em mulheres, pontua que os estudos de análise de segregação sugerem o envolvimento de um gene de efeito maior na etiologia do transtorno.…”

Section: B Estudos Com Gêmeosunclassified

“…O modelo de transmissão mais aceito para o TOC é o modelo misto ou complexo, que envolve a influência de diversos genes de pequeno efeito em interação com o ambiente (SAMPAIO et al, 2013). As estratégias comumente utilizadas são a eliciação e a discussão dos pensamentos automáticos e intrusivos, do medo disfuncional e dos esquemas de responsabilidade;…”

Section: B Estudos Com Gêmeosunclassified