ESWT and Ultrasound Imaging of the Musculoskeletal System

Bachmann, Christine E.; Konermann, W.; Arnold, Astrid; Gruber, Gerd; Ueberle, Friedrich; Gerdesmeyer, Ludger

doi:10.1007/978-3-642-48805-4

Cited by 12 publications

(11 citation statements)

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“…Extracorporeal pressure pulse therapy (frequently called ESWT extracorporeal shock wave therapy) was originally established in 1993 for the treatment of calcied shoulders and tendonitis in elbows and heel spur with focused lithotripter sources [1]. Due to the instantaneous and continuing success of the method, it was soon extended to the treatment of orthopedic pain situations in various body parts.…”

Section: Introductionmentioning

confidence: 99%

Unfocused/Weakly Focused Pressure Pulse Sources for Pain Therapy: Measurements in Water and in a Dry Test Bench

Ueberle¹,

Jamshidi-Rad²

2015

Acta Phys. Pol. A

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Unfocused/weakly focused pressure pulses (UPP) are generated by an air-gun like mechanism, with a projectile accelerated by pressurized air and impinging on a metal applicator. They were introduced in 1998 for the treatment of orthopedic soft tissue pain. The patient side of the applicator (a circular piston of 630 mm diameter) releases single pressure pulses of 210 MPa and 45 µs duration. Up today, there is no standard for the measurement of UPP sources (UPPS), so data are often reported on the basis of the focused lithotripter standard IEC61846. The purpose of this research is to establish methods to reliably measure UPPS acoustic parameters and establish a parameter set based on denitions from focused lithotripsy sources as applicable. Therefore, acoustic characteristics and wave elds of the pressure pulses of UPPS from dierent manufacturers were measured in a water bath and in a dry test bench. It was demonstrated by comparison with optical hydrophones that piezoelectric hydrophones are appropriate for the measurements of UPP. For on-axis measurements at a xed distance, measurements in the dry test bench can replace water-bath measurements. Additionally, the dry test bench allows for reliable results at pulse rates > 1 Hz.

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Section: Introductionmentioning

confidence: 99%

Unfocused/Weakly Focused Pressure Pulse Sources for Pain Therapy: Measurements in Water and in a Dry Test Bench

Ueberle¹,

Jamshidi-Rad²

2015

Acta Phys. Pol. A

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“…in the shoulder, the tennis elbow, or heel spur. ESWT was first developed using focused lithotripsy pressure pulse sources [1]. In 1999, an alternative technology, called "Radial Shock Waves" was introduced ("RESWT" devices).…”

Section: Introductionmentioning

confidence: 99%

Characterization of Unfocused / Weakly Focused Pressure Pulse Sources for Extracorporeal Pain Therapy (“Radial Shock Wave Therapy” Sources)

Ueberle

Rad

2013

Biomedical Engineering / Biomedizinische Technik

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Extracorporeal "Shock Wave" Therapy (ESWT) is widely and successfully used for the treatment of orthopedic pain situations. Based on measurements of different pressure pulse devices, a set of parameters for the characterization of unfocused / weakly focused pressure pulse sources is proposed, which may be used to initiate an internationally harmonized (IEC) standard for the measurement and characterization of these devices and to further develop an appropriate safety standard.

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“…Suitable FSW devices are commercially available and thus no complicated HIPU devices are needed for CNS applications. Similar to HIPU, FSW is well known to produce cavitation (Bachmann et al, 2001), which is believed to be the major mechanism responsible for BBB opening caused by negative pressureinduced cavitation (Wu, 2016;Hsu et al, 2018). However, BBB opening requires high FSW pressure levels required, and its safety has yet to be clarified.…”

Section: Introductionmentioning

confidence: 99%

A Single High-Intensity Shock Wave Pulse With Microbubbles Opens the Blood-Brain Barrier in Rats

Kung

Huang

Liao

et al. 2020

Front. Bioeng. Biotechnol.

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Focused extracorporeal shockwave (FSW), one kind of focused high-intensity pulsed ultrasound, has been shown to induce blood-brain barrier (BBB) opening in targeted brain areas in rat animal models with minimal detrimental effects below threshold intensity levels or iterations. In the current study, we found that the thresholds could be further reduced by the addition of microbubbles (ultrasound contrast agents or UCA; SonoVue). FSW with 2 × 10 6 MBs/kg of UCA (20% of clinical dosage) at an intensity level of 0.1 (peak positive pressure 5.4 MPa; peak negative pressure −4.2 MPa; energy flux density 0.03 mJ/mm 2) resulting in a 100% BBB opening rate without detectable hemorrhage or apoptosis in the brain. Significantly reduced free radical production was found compared with 0.5 MHz focused ultrasound at a peak negative pressure of 0.44 MPa (1% duty cycle and 4 × 10 7 MBs/kg of UCA). FSW devices offer advantages of commercial availability and high safety, and thus may facilitate future research and applications of focal BBB opening for oncological and pharmacological purposes.

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ESWT and Ultrasound Imaging of the Musculoskeletal System

Cited by 12 publications

References 0 publications

Unfocused/Weakly Focused Pressure Pulse Sources for Pain Therapy: Measurements in Water and in a Dry Test Bench

Unfocused/Weakly Focused Pressure Pulse Sources for Pain Therapy: Measurements in Water and in a Dry Test Bench

Characterization of Unfocused / Weakly Focused Pressure Pulse Sources for Extracorporeal Pain Therapy (“Radial Shock Wave Therapy” Sources)

A Single High-Intensity Shock Wave Pulse With Microbubbles Opens the Blood-Brain Barrier in Rats

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