ESX-3 secretion system in Mycobacterium: An overview

Granados-Tristán, Ana Laura; Hernández-Luna, Carlos Eduardo; González-Escalante, Laura Adiene; Camacho-Moll, María Elena; Silva-Ramírez, Beatriz; Bermúdez de León, Mario; Peñuelas-Urquides, Katia

doi:10.1016/j.biochi.2023.10.013

Cited by 4 publications

(2 citation statements)

References 99 publications

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“…In contrast, IdeR was expressed in the presence of excess iron in the cell. HupB and IdeR precisely regulate siderophores biosynthesis under low and high iron concentrations, respectively ( Pandey and Rodriguez, 2014 ; Pandey et al., 2014a ; Granados-Tristán et al., 2023 ). HupB promotes the expression of MBT and cMBT, and it induces the Th2 immune response.…”

Section: Metal Ion-dependent Proteinsmentioning

confidence: 99%

“…ESX-3 secretion system is required for MBT-mediated iron acquisition ( Siegrist et al., 2009 ), and expression of the esx-3 operon is regulated by Zur and IdeR, to maintain the dynamic balance of Zn and iron, respectively ( Rodriguez et al., 2002 ; Serafini et al., 2013 ; Kim et al., 2017 ; Li et al., 2020 ). Under high iron and Zn concentrations, metalloproteins negatively regulate ESX-3 transcription ( Granados-Tristán et al., 2023 ). In M. smegmatis , ESX-3 T7SS is involved in metal dynamic homeostasis, therefore, we hypothesized that ESX-3 T7SS is closely related to the virulence of MTB.…”

Section: Metal Ion-dependent Proteinsmentioning

confidence: 99%

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The role of transcriptional regulators in metal ion homeostasis of Mycobacterium tuberculosis

Wang,

Fang,

Wang

et al. 2024

Front. Cell. Infect. Microbiol.

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Metal ions are essential trace elements for all living organisms and play critical catalytic, structural, and allosteric roles in many enzymes and transcription factors. Mycobacterium tuberculosis (MTB), as an intracellular pathogen, is usually found in host macrophages, where the bacterium can survive and replicate. One of the reasons why Tuberculosis (TB) is so difficult to eradicate is the continuous adaptation of its pathogen. It is capable of adapting to a wide range of harsh environmental stresses, including metal ion toxicity in the host macrophages. Altering the concentration of metal ions is the common host strategy to limit MTB replication and persistence. This review mainly focuses on transcriptional regulatory proteins in MTB that are involved in the regulation of metal ions such as iron, copper and zinc. The aim is to offer novel insights and strategies for screening targets for TB treatment, as well as for the development and design of new therapeutic interventions.

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Section: Metal Ion-dependent Proteinsmentioning

confidence: 99%

Section: Metal Ion-dependent Proteinsmentioning

confidence: 99%

The role of transcriptional regulators in metal ion homeostasis of Mycobacterium tuberculosis

Wang,

Fang,

Wang

et al. 2024

Front. Cell. Infect. Microbiol.

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Stealing survival: Iron acquisition strategies of Mycobacterium tuberculosis

Shankar,

Akhter

2024

Biochimie

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Protease shaving ofMycobacterium tuberculosisfacilitates vaccine antigen discovery and delivery of novel cargoes to the Mtb surface

Lepe,

Zheng,

Leddy

et al. 2024

Preprint

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Tuberculosis (TB), caused byMycobacterium tuberculosis(Mtb), is the leading cause of infectious disease death and lacks a vaccine capable of protecting adults from pulmonary TB. Studies have shown that Mtb uses a variety of mechanisms to evade host immunity. Secreted Mtb proteins such as Type VII secretion system substrates have been characterized for their ability to modulate anti-Mtb immunity; however, studies of other pathogens such asSalmonellaTyphi andStaphylococcus aureushave revealed that outer membrane proteins can also interact with the innate and adaptive immune system. The Mtb outer membrane proteome has received relatively less attention due to limited techniques available to interrogate this compartment. We filled this gap by deploying protease shaving and quantitative mass spectrometry to identify Mtb outer membrane proteins which serve as nodes in the Mtb-host interaction network. These analyses revealed several novel Mtb proteins on the Mtb surface largely derived from the PE/PPE class of Mtb proteins, including PPE18, a component of a leading Mtb vaccine candidate. We next exploited the localization of PPE18 to decorate the Mtb surface with heterologous proteins and deliver these surface-engineered Mtb to the phagosome. Together, these studies reveal potential novel targets for new Mtb vaccines as well as facilitate new approaches to study difficult to study cellular compartments during infection.

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ESX-3 secretion system in Mycobacterium: An overview

Cited by 4 publications

References 99 publications

The role of transcriptional regulators in metal ion homeostasis of Mycobacterium tuberculosis

The role of transcriptional regulators in metal ion homeostasis of Mycobacterium tuberculosis

Stealing survival: Iron acquisition strategies of Mycobacterium tuberculosis

Protease shaving ofMycobacterium tuberculosisfacilitates vaccine antigen discovery and delivery of novel cargoes to the Mtb surface

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