Et₄NCl-Promoted Electrochemical Atherton-Todd Type Reaction to Construct P(O)–F Bonds

Abstract

An electrochemical synthetic strategy to construct P(O)−F bonds was developed via the Atherton−Todd reaction. Promoted by Et 4 NCl, a series of biologically active phosphoric fluorides were synthesized by use of commercially available P(O)−H feedstocks and Et 3 N•3HF as the F-source. With this protocol, some potentially functional P(O)−OR and P(O)−SR motifs could also be smoothly forged. This sustainable fluorination approach features step-economy, is chemicaloxidant-and metal-catalyst-free, and offers low cost and mild conditions. Additionally, cyclic voltammetry and control experiments were conducted to propose a reasonable mechanism. Article pubs.acs.org/joc