Etanercept Inhibits Pro-inflammatory Cytokines Expression in Titanium Particle-Stimulated Peritoneal Macrophages

Abstract

Purpose: To investigate the inhibitory role of Etanercept in pro-inflammatory cytokines such as (34.79 ± 7.83 pg/mL, p > 0.05), 21.06 % at 100 ng/mL (28.98 ± 4.81 pg/mL, p < 0.01) and 29.83 % at 1000 ng/mL (25.76 ± 5.23 pg/ml, p < 0.001), and IL-6 release by 38.69 % at 10 ng/mL (256.8 ± 99.56 pg/mL, p < 0.01), by 42.13 % at 100 ng/mL (242.4 ± 33.26 pg/mL, p < 0.01) and 53.4 % at 1000 ng/ml (195.2 ± 48.82 pg/mL, p < 0.001). Conclusion: Etanercept has potent ability to prevent wear debris-induced osteolysis and may be valuable as a therapeutic agent for the treatment of prosthetic loosening in humans.

Inhibitory effect of quercetin on titanium particle induced endoplasmic reticulum stress related apoptosis and in vivo osteolysis

“…However, aseptic loosening due to periprosthetic osteolysis, induced by the adverse biological responses to wear particles, can damage the efficacy and longevity of the prosthetic components [ 3 , 4 ]. The particles generated from the mechanical wear of prosthetic components can be phagocytosed by macrophages and other inflammatory cells [ 5 ]. During the pathological process, the macrophages activated by Ti particles release proinflammatory cytokines including interleukin (IL)-6, IL-1β and tumor necrosis factor α (TNF-α).…”