Etanercept or Methotrexate Withdrawal in Rheumatoid Arthritis Patients Receiving Combination Therapy: Comment on the Article by Curtis et al

Roongta, Rashmi; Mondal, Sumantro; Ghosh, Alakendu

doi:10.1002/art.41719

Cited by 1 publication

(1 citation statement)

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“…A biological TNF antagonist inhibiting the interaction of TNF-α and lymphotoxin (TNF-β) with cell-surface receptors, whereby TNF-mediated cellular responses and the activity of other pro-inflammatory cytokines are modulated. [181][182][183][184]…”

Section: Etanercept)mentioning

confidence: 99%

Recent Advances in Understanding the Pathogenesis of Rheumatoid Arthritis: New Treatment Strategies

Mueller

Payandeh

Mohammadkhani

et al. 2021

Cells

122

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Rheumatoid arthritis (RA) is considered a chronic systemic, multi-factorial, inflammatory, and progressive autoimmune disease affecting many people worldwide. While patients show very individual courses of disease, with RA focusing on the musculoskeletal system, joints are often severely affected, leading to local inflammation, cartilage destruction, and bone erosion. To prevent joint damage and physical disability as one of many symptoms of RA, early diagnosis is critical. Auto-antibodies play a pivotal clinical role in patients with systemic RA. As biomarkers, they could help to make a more efficient diagnosis, prognosis, and treatment decision. Besides auto-antibodies, several other factors are involved in the progression of RA, such as epigenetic alterations, post-translational modifications, glycosylation, autophagy, and T-cells. Understanding the interplay between these factors would contribute to a deeper insight into the causes, mechanisms, progression, and treatment of the disease. In this review, the latest RA research findings are discussed to better understand the pathogenesis, and finally, treatment strategies for RA therapy are presented, including both conventional approaches and new methods that have been developed in recent years or are currently under investigation.

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Section: Etanercept)mentioning

confidence: 99%