Etanol y carcinogénesis cólica experimental

Aguilar, J. L.; García, Ángel Cuadrado

doi:10.4321/s1130-01082007000800002

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…CYP2E1 has been unambiguously shown to be an important enzyme involved in DMH/AOM metabolism [111]. It has also been found that simultaneous administration of DMH/AOM and alcohol inhibits colon carcinogenesis, probably due to suppression of DMH/AOM activation in the liver [112, 113]. DMH/AOM-induced colon carcinogenesis may thus be either inhibited or enhanced by substances that are administered during the initiation stage.…”

Section: Limitations Of the Dmh/aom Rat Modelmentioning

confidence: 99%

Morphological and Molecular Alterations in 1,2 Dimethylhydrazine and Azoxymethane Induced Colon Carcinogenesis in Rats

Perše

Cerar

2010

BioMed Research International

205

184

View full text Add to dashboard Cite

The dimethyhydrazine (DMH) or azoxymethane (AOM) model is a well-established, well-appreciated, and widely used model of experimental colon carcinogenesis. It has many morphological as well as molecular similarities to human sporadic colorectal cancer (CC), which are summarized and discussed in this paper. In addition, the paper combines present knowledge of morphological and molecular features in the multistep development of CC recognized in the DMH/AOM rat model. This understanding is necessary in order to accurately identify and interpret alterations that occur in the colonic mucosa when evaluating natural or pharmacological compounds in DMH/AOM rat colon carcinogenesis. The DMH/AOM model provides a wide range of options for investigating various initiating and environmental factors, the role of specific dietary and genetic factors, and therapeutic options in CC. The limitations of this model and suggested areas in which more research is required are also discussed.

show abstract

Section: Limitations Of the Dmh/aom Rat Modelmentioning

confidence: 99%