2023
DOI: 10.3390/ijms24054759
|View full text |Cite
|
Sign up to set email alerts
|

ETC-159, an Upstream Wnt inhibitor, Induces Tumour Necrosis via Modulation of Angiogenesis in Osteosarcoma

Abstract: There is an increasing urgency in the search for new drugs to target high-grade cancers such as osteosarcomas (OS), as these have limited therapeutic options and poor prognostic outlook. Even though key molecular events leading to tumorigenesis are not well understood, it is widely agreed that OS tumours are Wnt-driven. ETC-159, a PORCN inhibitor that inhibits the extracellular secretion of Wnt, has recently progressed on to clinical trials. In vitro and in vivo murine and chick chorioallantoic membrane xenogr… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1

Citation Types

0
1
0

Year Published

2023
2023
2025
2025

Publication Types

Select...
5
1

Relationship

0
6

Authors

Journals

citations
Cited by 6 publications
(1 citation statement)
references
References 50 publications
0
1
0
Order By: Relevance
“…Inhibitors of Porcupine prevent the secretion of Wnt ligands, thereby obstructing the activation of Wnt signaling. Several such inhibitors, including LGK974 and ETC-159, are presently under evaluation in clinical trials for the treatment of Wnt-driven cancers, including CRC [ 128 , 129 , 130 ].…”
Section: The Role Of the Wnt Signaling Pathway In Crc Tumor Stroma De...mentioning
confidence: 99%
“…Inhibitors of Porcupine prevent the secretion of Wnt ligands, thereby obstructing the activation of Wnt signaling. Several such inhibitors, including LGK974 and ETC-159, are presently under evaluation in clinical trials for the treatment of Wnt-driven cancers, including CRC [ 128 , 129 , 130 ].…”
Section: The Role Of the Wnt Signaling Pathway In Crc Tumor Stroma De...mentioning
confidence: 99%