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Braun, Michael; Clemmons, M. A.; Lurie, Gordon; Simunich, K. L.; Timmerman, D.; VanderZee, H.; Widing,

doi:10.2172/821665

Cited by 3 publications

(3 citation statements)

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“…Siderophore chelates the ferric ion with high affinity and establishes a soluble complex that can be taken up by a specific membrane transporter. [1] It has been reported that actinomycetes produce a wide variety of siderophores. [2] Desferroxiamine was isolated from Streptomyces pilous and has been used as an effective medical agent to cure hemochromatosis.…”

Section: Introductionmentioning

confidence: 99%

A New Siderophore Isolated from Streptomyces sp. TM‐34 with Potent Inhibitory Activity Against Angiotensin‐Converting Enzyme

Kodani¹,

Ohnishi‐Kameyama

Yoshida

et al. 2011

Eur J Org Chem

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A new siderophore named tsukubachelin was isolated from an iron-deficient culture medium of newly isolated strain Streptomyces sp. TM-34. The chemical structure of tsukubachelin was established by the interpretation of 2D NMR and TOF-Mass spectroscopic data. The structure of tsukubachelin consists of six amino acid residues, including three serine, and one each of N-α-methyl-N-δ-hydroxy-N-δ-formylornithine, N-α-methyl-N-δ-hydroxyornithine, and cyclic Nhydroxyornithine. Because the structurally related sidero-

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Section: Introductionmentioning

confidence: 99%

A New Siderophore Isolated from Streptomyces sp. TM‐34 with Potent Inhibitory Activity Against Angiotensin‐Converting Enzyme

Kodani¹,

Ohnishi‐Kameyama

Yoshida

et al. 2011

Eur J Org Chem

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“…Hence, the introduction of a catecholate mask connected via an alkyl chain (15) or via enzyme-cleavable linkers (13,14), was realized. [13][14][15][16][17][18]…”

Section: Prodrug Design Strategymentioning

confidence: 99%

Bacterial RNAP Inhibitors: Synthesis and Evaluation of Prodrugs of Aryl‐ureidothiophene‐carboxylic acids

et al. 2017

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Recently, aryl‐ureidothiophene carboxylates were shown to inhibit the RNA polymerase and reduce the growth of Gram positive bacteria. We now aimed to extend the efficacy spectrum and address presumed permeation deficiencies of these agents by applying different prodrug‐approaches. Chemical syntheses yielded 12 prodrugs of three different categories featuring neutral, cationic and FeIII ‐coordinating properties. Their promising characteristics regarding stabilities, enzyme‐activation and iron coordination performance encouraged their study in growth inhibition assays of different Gram positive and Gram negative bacterial strains. These studies pointed to a positively charged, choline‐like motif being beneficial for these compounds especially for Gram‐negative bacterial cell growth inhibition.

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“…Moreover, bacteria that infect humans and animals may use iron sources of their hosts, such as heme, hemoglobin, hemopexin, and iron bound to transferrin and lactoferrin [4]. In Gram-negative bacteria, which contain an outer membrane, all iron sources are bound to highly speci¢c proteins that serve as transporters across the outer membrane [5]. In Gram-positive bacteria, which contain a permeable cell wall, the iron sources gain direct access to the cytoplasmic membrane.…”

Section: Introductionmentioning

confidence: 99%

Iron Transport In Escherichia coli

Braun

Killmann³

Advances in Experimental Medicine and Biology

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Bacteria solve the iron supply problem caused by the insolubility of Fe 3+ by synthesizing iron-complexing compounds, called siderophores, and by using iron sources of their hosts, such as heme and iron bound to transferrin and lactoferrin. Escherichia coli, as an example of Gram-negative bacteria, forms sophisticated Fe 3+^s iderophore and heme transport systems across the outer membrane. The crystal structures of three outer membrane transport proteins now allow insights into energy-coupled transport mechanisms. These involve large longrange structural transitions in the transport proteins in response to substrate binding, including substrate gating. Energy is provided by the proton motive force of the cytoplasmic membrane through the activity of a protein complex that is inserted in the cytoplasmic membrane and that contacts the outer membrane transporters. Certain transport proteins also function in siderophore-mediated signaling cascades that start at the cell surface and £ow to the cytoplasm to initiate transcription of genes encoding proteins for transport and siderophore biosynthesis. ß

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ETEdit v.8.1 user's manual.

Cited by 3 publications

References 0 publications

A New Siderophore Isolated from Streptomyces sp. TM‐34 with Potent Inhibitory Activity Against Angiotensin‐Converting Enzyme

A New Siderophore Isolated from Streptomyces sp. TM‐34 with Potent Inhibitory Activity Against Angiotensin‐Converting Enzyme

Bacterial RNAP Inhibitors: Synthesis and Evaluation of Prodrugs of Aryl‐ureidothiophene‐carboxylic acids

Iron Transport In Escherichia coli

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