Ethanol administration results in a prolonged decrease in blood ionized calcium levels in the rat

Keiver, Kathy; Duggal, Shalu; Simpson, M.E.

doi:10.1016/j.alcohol.2005.07.008

Cited by 18 publications

(26 citation statements)

References 31 publications

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“…The BEC determinations were made using the NAD-ADH enzymatic assay (Sigma). BEC was measured using a spectrophotometric method based on the conversion of ethanol to acetaldehyde by alcohol dehydrogenase (Keiver et al, 2005). The concentration of ethanol in the blood samples was calculated using an ethanol standard curve.…”

Section: Determination Of Blood Ethanol Concentration (Bec)mentioning

confidence: 99%

Viral-Mediated Knockdown of mGluR7 in the Nucleus Accumbens Mediates Excessive Alcohol Drinking and Increased Ethanol-Elicited Conditioned Place Preference in Rats

Bahí

2012

Neuropsychopharmacol

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Whether metabotropic glutamate 7 (mGluR7) -activation enhances or diminishes the reinforcing properties of psychostimulants remains unclear. We have previously shown that systemic mGluR7 activation reduced alcohol consumption and preference as well as locomotorstimulating and rewarding properties of ethanol. In this study, we further examined the contribution of mGluR7 on the effect of ethanol within the nucleus accumbens (NAcc), a neural target for many drugs of abuse. Using short hairpin RNA (shRNA)-expressing lentiviral vectors (LV) to alter locally the activity of mGluR7 in male rats, we have shown that blocking mGluR7 expression increased ethanol consumption and preference in a two-bottle choice drinking paradigm with no effect either on saccharin or on quinine used for taste discrimination. In addition, mGluR7 knockdown increases preference for environments previously paired with low doses of ethanol in the conditioned place preference (CPP) test, as it shifted the dose-response curve for ethanol CPP to the left, indicating alterations in the rewarding effects of alcohol. More importantly, mGluR7 blockade in the dorsal striatum (DS) neither affected ethanol consumption nor ethanol-elicited CPP. These results show that levels of mGluR7 in the NAcc regulate responsiveness to alcohol. Taken together, these findings clearly demonstrate that mGluR7 signaling within the NAcc is a key modulator of functional responses to ethanol and offer an important target for regulating the addictive effects of alcohol.

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Section: Determination Of Blood Ethanol Concentration (Bec)mentioning

confidence: 99%

Viral-Mediated Knockdown of mGluR7 in the Nucleus Accumbens Mediates Excessive Alcohol Drinking and Increased Ethanol-Elicited Conditioned Place Preference in Rats

Bahí

2012

Neuropsychopharmacol

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“…Estudos em ratas demonstraram uma redução dose-dependente e duradoura dos níveis de cálcio no sangue associados ao consumo de etanol, sugerindo que a resposta hormonal de regulação deste mineral é afetada pelo etanol e que, possivelmente, reflita na formação óssea (Kayath et al, 1999;Keiver et al, 2005 (Quarles, 2008).…”

Section: Revisão De Literaturaunclassified

“…A exposição crônica a altas concentrações de etanol pode acarretar atraso no crescimento e desenvolvimento ósseo (Keiver et al, 2005;Lauing et al, 2008), redução da remodelação e da resistência óssea (Turner, 2000;Chakkalakal et al, 2005), e piora na qualidade do reparo ósseo (Chakkalakal, 2005;Deco, 2009). Por causa desta relação entre etanol e osso, a ruptura do equilíbrio mineral ósseo pode refletir nos parâmetros bioquímicos de cálcio e fosfato ósseo e elevar o risco de osteoporose (Keiver et al, 2005).…”

Section: Parâmetros Bioquímicosunclassified

“…Por causa desta relação entre etanol e osso, a ruptura do equilíbrio mineral ósseo pode refletir nos parâmetros bioquímicos de cálcio e fosfato ósseo e elevar o risco de osteoporose (Keiver et al, 2005).…”

Section: Parâmetros Bioquímicosunclassified

“…Alguns autores postulam que a hipocalcemia plasmática provocada pelo consumo elevado de etanol é transitória (Diez et al, 1997) e dependente da ação do PTH (Keiver et al, 2005). Sabe-se que o PTH é secretado numa taxa inversamente proporcional à concentração do cálcio, e que sob alcoolemia elevada, o sistema que regula esta homeostasia é rompido.…”

Section: Parâmetros Bioquímicosunclassified

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Repercussões minerais ósseas no alcoolismo crônico associado à deficiência hormonal em ratos

Lodi¹

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Principles of Safety Pharmacology

2015

Handbook of Experimental Pharmacology

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Ethanol administration results in a prolonged decrease in blood ionized calcium levels in the rat

Cited by 18 publications

References 31 publications

Viral-Mediated Knockdown of mGluR7 in the Nucleus Accumbens Mediates Excessive Alcohol Drinking and Increased Ethanol-Elicited Conditioned Place Preference in Rats

Viral-Mediated Knockdown of mGluR7 in the Nucleus Accumbens Mediates Excessive Alcohol Drinking and Increased Ethanol-Elicited Conditioned Place Preference in Rats

Repercussões minerais ósseas no alcoolismo crônico associado à deficiência hormonal em ratos

Principles of Safety Pharmacology

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