Ethanol and Hormesis

Calabrese, Edward J.; Baldwin, Linda A.

doi:10.1080/713611043

Cited by 57 publications

(33 citation statements)

References 103 publications

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“…They also stated that regardless of actual response mechanisms, the similarity of dose-response characteristics likely reflected an important overall regulatory strategy built into the framework of a homeostatic control system. Calabrese and Baldwin (2003c) further noted that these collective findings closely resembled the biphasic hormetic responses to a wide range of toxic chemical agents that they had previously reported (Calabrese and Baldwin, 1997).…”

Section: Hormetic Alcohol (Ethanol)supporting

confidence: 71%

“…For non-human mammalian biological end points (including, amongst others, the liver, kidney, heart, spleen, endocrine, embryonic development and birth weight), Calabrese and Baldwin's (2003c) assessment of the toxicological and pharmacological literature demonstrated ethanol-induced biphasic dose responses over a wide range. In most cases, the low-dose hormetic responses were judged to be statistically significant and reliable.…”

Section: Hormetic Alcohol (Ethanol)mentioning

confidence: 99%

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Nutritional hormesis

Hayes

2006

Eur J Clin Nutr

111

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Objective: Hormesis, the biological and toxicological concept that small quantities have opposite effects from large quantities, is reviewed with emphasis on its relevance to nutrition. Results: Hormetic and other dose-response relationships are categorized, depicted, and discussed. Evidence for nutritional hormesis is presented for essential vitamin and mineral nutrients, dietary restriction, alcohol (ethanol), natural dietary and some synthetic pesticides, some herbicides, and acrylamide. Some of the different hormetic mechanisms that have been proposed are reviewed. Conclusions:The credence and relevance of hormesis to nutrition are considered to be established. The roles of hormesis in nutritional research and in formulating nutritional guidelines are discussed.

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Section: Hormetic Alcohol (Ethanol)supporting

confidence: 71%

Section: Hormetic Alcohol (Ethanol)mentioning

confidence: 99%

Nutritional hormesis

Hayes

2006

Eur J Clin Nutr

111

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“…The relationship between smoking or drinking dose and risk for stomach cancer has also attracted great interest as to whether strict dose-dependence or a U-shaped curve might be evident 77 . Recently, the risk of stomach cancer was reported to increase linearly with the smoking dose, but not with the drinking dose.…”

Section: Hormetic Effects Observed With Ethanolmentioning

confidence: 99%

Hormesis in Carcinogenicity of Non-genotoxic Carcinogens

et al. 2006

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Abstract:Recently the idea of hormesis, a biphasic dose-response relationship in which a chemical exerts opposite effects dependent on the dose, has attracted interest in the field of carcinogenesis. With non-genotoxic agents there is considerable experimental evidence in support of hormesis and the present review highlights current knowledge of doseresponse effects. In particular, several in vivo studies have provided support for the idea that non-genotoxic carcinogens may inhibit hepatocarcinogenesis at low doses. Here, we survey the examples and discuss possible mechanisms of hormesis with cytochrome P450 inducers, such as phenobarbital, 1,1-bis(p-chlorophenyl)-2,2,2-trichloroethane (DDT), α-benzene hexachloride (α-BHC), and other non-genotoxins. Epigenetic processes differentially can be affected by agents that impinge on oxidative stress, DNA repair, cell proliferation, apoptosis, intracellular communication and cell signaling. Non-genotoxic carcinogens may target nuclear receptors, cause aberrant DNA methylation at the genomic level and induce post-translational modifications at the protein level, thereby impacting on the stability or activity of key regulatory proteins, including oncoproteins and tumor suppressor proteins. Via multiple epigenetic lesions, nongenotoxic carcinogens can elicit a variety of changes contributing to cellular carcinogenesis. (J Toxicol Pathol 2006; 19: 111-122)

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“…Thereafter, for the purposes of this book, we will focus on chemical hormesis alone. Some of the most familiar examples of biphasic dose-responses include vitamins, alcohol, essential minerals, and many drugs (16,17,18,19,20). Hormesis has been measured using diverse endpoints in multiple biological systems (8).…”

Section: Introductionmentioning

confidence: 99%