Ethanol and Pain Sensitivity: Effects in Healthy Subjects Using an Acute Pain Paradigm

Perrino, Albert C.; Ralevski, Elizabeth; Acampora, Gregory; Edgecombe, Javon; Limoncelli, Diana; Petrakis, Ismene L.

doi:10.1111/j.1530-0277.2008.00653.x

Cited by 51 publications

(53 citation statements)

References 32 publications

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“…Alcohol has analgesic effects, elevating pain tolerance in healthy volunteers (Perrino et al, 2008). However, withdrawal from alcohol is associated with increased pain sensitivity (Jochum et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

Pain is associated with risky drinking over time among HIV-infected persons in St. Petersburg, Russia

Tsui¹,

Cheng²,

Coleman³

et al. 2014

Drug and Alcohol Dependence

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Background Pain is highly prevalent among persons with HIV. Alcohol may be used to “self-medicate” pain. This study examined the association between pain and risky alcohol use over time in a cohort of HIV-infected Russian drinkers. Methods This secondary analysis utilized longitudinal data from a randomized trial of a behavioral intervention. Subjects included HIV-infected adults who reported past 6-month risky drinking and unprotected sex and were recruited from HIV and addiction treatment sites in St. Petersburg, Russia. The main independent variable was pain that at least moderately interfered with daily living. The primary outcome was past month risky drinking amounts based on NIAAA guidelines. General estimating equations (GEE) logistic regression models were used to calculate odds ratios and 95% confidence intervals for the association between pain and risky drinking over time (i.e., baseline, 6- and 12-months), adjusting for potential confounders. Results Baseline characteristics of participants (n=699) were mean age of 30 (SD±5) years, 41% female, and 22% < 9th grade education. Nearly one quarter (24%) had a CD4 cell count <200 cells/μ/l, and only 17% were on antiretroviral therapy. Nearly half (46%) reported at least moderate pain interference in the past month and 81% were drinking risky amounts. In adjusted longitudinal GEE models, pain was significantly associated with greater odds of reporting past month risky drinking (AOR=1.34, 95% CI: 1.05-1.71, p-value=0.02). Conclusions Among a cohort of HIV-infected Russian drinkers, pain that at least moderately interfered with daily living was associated with higher odds of reporting risky drinking amounts over time.

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Section: Discussionmentioning

confidence: 99%

Pain is associated with risky drinking over time among HIV-infected persons in St. Petersburg, Russia

Tsui¹,

Cheng²,

Coleman³

et al. 2014

Drug and Alcohol Dependence

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show abstract

“…Only a few cases (about 15%) reported very mild and transient headache in the hours after a 3-hour clamp, perhaps as a function of withdrawal (Zimmermann US, O'Connor S, 2010, personal communications). Another alcohol-clamping procedure study in 60 medically and neurologically healthy patients did not report headache among patients within 1 h [30]. Experiments with this technique in migraineurs should be of much interest.…”

Section: Is Alcohol Per Se or A Component Of Alcoholic Drinks The Hmentioning

confidence: 93%

“…Rats that received dural stimulation followed by alcohol showed an initial analgesic effect within the first 2 h after alcohol ingestion, but 4-6 h later, their pain sensitivity increased. Similarly, experiments in humans have shown that intravenous alcohol has an analgesic effect with increased pain sensitivity found in alcohol withdrawal [30,31].…”

Section: Is Alcohol Per Se or A Component Of Alcoholic Drinks The Hmentioning

confidence: 98%

Alcohol and Migraine: What Should We Tell Patients?

Panconesi

Bartolozzi

Guidi

2011

Curr Pain Headache Rep

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Alcoholic drinks are a migraine trigger in about one third of patients with migraine in retrospective studies on trigger factors. Many population studies show that patients with migraine consume alcohol in a smaller percentage than the general population. Moreover, research has shown a decreased prevalence of headache with increasing number of alcohol units consumed. The classification criteria of alcohol-related headaches remain problematic. We discuss the role and mechanism of action of alcohol or other components of alcoholic drinks in relation to alcohol-induced headache. In accordance with data from a recent prospective study, we believe that reports overestimate the role of alcohol, as well as other foods, in the triggering of migraine. If a relationship between the intake of alcohol and the migraine attack is not clear, a small dose of alcohol is not contraindicated either for enjoyment or its protective effect on cardiovascular disease.

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“…Even a single episode of excessive ethanol drinking can lead to negative outcomes such as violent crimes, aggression and increased risk of accidents, injury and death [3], [4]. These negative outcomes are linked to ethanol's impact on complex behaviors such as ability to induce behavioral disinhibition [5], sedation [6], [7], analgesia [8] and learning and memory deficits [9]. The mechanisms underlying these effects require further investigation in humans and model organisms.…”

Section: Introductionmentioning

confidence: 99%

Ethanol-Induced Effects on Sting Extension Response and Punishment Learning in the Western Honey Bee (Apis mellifera)

et al. 2014

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Acute ethanol administration is associated with sedation and analgesia as well as behavioral disinhibition and memory loss but the mechanisms underlying these effects remain to be elucidated. During the past decade, insects have emerged as important model systems to understand the neural and genetic bases of alcohol effects. However, novel assays to assess ethanol's effects on complex behaviors in social or isolated contexts are necessary. Here we used the honey bee as an especially relevant model system since bees are typically exposed to ethanol in nature when collecting standing nectar crop of flowers, and there is recent evidence for independent biological significance of this exposure for social behavior. Bee's inhibitory control of the sting extension response (SER) and a conditioned-place aversion assay were used to study ethanol effects on analgesia, behavioral disinhibition, and associative learning. Our findings indicate that although ethanol, in a dose-dependent manner, increases SER thresholds (analgesic effects), it disrupts the ability of honey bees to inhibit SER and to associate aversive stimuli with their environment. These results suggest that ethanol's effects on analgesia, behavioral disinhibition and associative learning are common across vertebrates and invertebrates. These results add to the use of honey bees as an ethanol model to understand ethanol's effects on complex, socially relevant behaviors.

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Ethanol and Pain Sensitivity: Effects in Healthy Subjects Using an Acute Pain Paradigm

Abstract: The findings support the hypothesis that in healthy subjects intravenous ethanol administration has a concentration effect on pain tolerance but not on pain threshold. Additional studies are planned to further elucidate the mechanisms of ethanol's analgesic effects.

Cited by 51 publications

References 32 publications

Pain is associated with risky drinking over time among HIV-infected persons in St. Petersburg, Russia

Pain is associated with risky drinking over time among HIV-infected persons in St. Petersburg, Russia

Alcohol and Migraine: What Should We Tell Patients?

Ethanol-Induced Effects on Sting Extension Response and Punishment Learning in the Western Honey Bee (Apis mellifera)

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