Ethanol and thermal ablation for malignant thyroid tumours

Jeong, Sang Ho; Baek, Jung Hwan; Choi, Young Jun; Lee, Jeong Hyun

doi:10.1080/02656736.2017.1361048

Cited by 30 publications

(48 citation statements)

References 68 publications

(210 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recently, treatment of mPTC with ablative techniques such as laser, radiofrequency, microwave or percutaneous ethanol injection has been reported (38)(39)(40)(41). Although studies have demonstrated the shortterm efficacy and safety of these procedures, it is the current opinion of this panel that there is no evidence of their superiority over active surveillance in patients who are candidates for the latter, or of their superiority over surgery when it is indicated and feasible.…”

Section: Recommendationmentioning

confidence: 99%

Thyroid nodules ≤ 1 cm and papillary thyroid microcarcinomas: Brazilian experts opinion

Rosário¹,

Ward²,

Graf³

et al. 2019

Archives of Endocrinology and Metabolism

View full text Add to dashboard Cite

The indolent evolution of low-risk papillary thyroid microcarcinoma (mPTC) in adult patients and the consequences of thyroidectomy require a revision of the management traditionally recommended. Aiming to spare patients unnecessary procedures and therapies and to optimize the health system in Brazil, we suggest some measures. Fine-needle aspiration of nodules ≤ 1 cm without extrathyroidal extension on ultrasonography should be performed only in nodules classified as "very suspicious" (i.e., high suspicion according to ATA, high risk according to AACE, TI-RADS 5) and in selected cases [age < 40 years, nodule adjacent to the trachea or recurrent laryngeal nerve (RLN), multiple suspicious nodules, presence of hypercalcitoninemia or suspicious lymph nodes]. Active surveillance (AS) rather than immediate surgery should be considered in adult patients with low-risk mPTC. Lobectomy is the best option in patients with unifocal low-risk mPTC who are not candidates for AS because of age, proximity of the tumor to the trachea or RLN, or because they opted for surgery. The same applies to patients who started AS but had a subsequent surgical indication not due to a suspicion of tumor extension beyond the gland or multicentricity. Molecular tests are not necessary to choose between AS and surgery or, in the latter case, between lobectomy and total thyroidectomy. The presence of RAS or other RAS-like mutations or BRAFV600E or other BRAF V600E-like mutations should not modify the management cited above; however, the rare cases of mPTC exhibiting high-risk mutations, like in the TERT promoter or p53, are not candidates for AS.

show abstract

Section: Recommendationmentioning

confidence: 99%

Thyroid nodules ≤ 1 cm and papillary thyroid microcarcinomas: Brazilian experts opinion

Rosário¹,

Ward²,

Graf³

et al. 2019

Archives of Endocrinology and Metabolism

View full text Add to dashboard Cite

show abstract

“…As an alternative option to surgery, image guided ablation has the advantage of minimal invasiveness, and had been successfully performed using different techniques in the past few years, including ethanol ablation [7], radiofrequency ablation (RFA) [8], microwave ablation [9], laser ablation [10] and so on. Among those techniques, RFA was most commonly applied and had been proved to be safe and effective for the treatment of benign thyroid nodules [8], and a recently published guideline based on Delphi method suggested that thermal ablation may be proposed as a first line treatment for solid nonfunctioning thyroid nodules that are benign at cytology when they become symptomatic [11].…”

Section: Introductionmentioning

confidence: 99%

Ultrasound-guided radiofrequency ablation for papillary thyroid microcarcinoma: a retrospective analysis of 198 patients

Luo

Tang

et al. 2020

International Journal of Hyperthermia

View full text Add to dashboard Cite

Purpose: To evaluate the safety and efficacy of ultrasound-guided RFA for the treatment of papillary thyroid microcarcinoma (PTMC). Materials and methods: The data of 204 nodules from 198 PTMC patients who were treated using RFA were retrospectively reviewed in this study. Demographic variables, complication details and CEUS results in different time points were collected. The volumes and volume reduction rate (VRR) of the ablated area under CEUS at different follow-up time points were calculated and compared. Results: All the patients were successfully treated without major complication. Mild complications included cervical discomfort in three cases, postoperative cervical pain in one case, and transient hoarse voice in five cases. The volume of the ablated area in the 1st, 3rd, 6th, 12th, 18th and 24th month postoperatively were 241.7 ± 298.3mm 3 , 89.8 ± 147.2 mm 3 , 37.6 ± 87.2 mm 3 , 13.6 ± 59.8 mm 3 , 2.4 ± 14.4 mm 3 , and 0.2 ± 2.0 mm 3 respectively, with a statistically significant decrease (F ¼ 138.1, p ¼ .000), and the VRR in those time points were 73.9 ± 13.7%, 90.5 ± 8.2%, 96.1 ± 5.9%, 98.8 ± 3.2%, 99.6 ± 1.9% and 99.8 ± 1.0% respectively, with a statistically significant decrease (F ¼ 695.3, p ¼ .000). Conclusions: US-guided RFA is safe and effective for PTMC, with a good oncological outcome and VRR. Further randomized controlled prospective trials are still needed to compare the value of RFA and surgery.

show abstract

“…The rate of tumor complete disappearance ranged from 25% to 94% of cancers with an improvement in therapeutic success and symptoms ranging from 75% to 97% and 64%, respectively. Moreover, in many patients a decrease in serum thyroglobulin concentration was described (88,(102)(103)(104)(105)(106)(107)(108)(109)(110)(111). A recent metaanalysis made by Suh et al compared the effectiveness and safety of RFA and PEI for the treatment of total sample size of recurrent thyroid cancers in 270 patients with a VRR ≥50% rate of 100.0% after RFA and of 89.5% after PEI associated to a rate of complete disappearance of the nodules of 68.8% and 53.4%, respectively.…”

Section: Resultsmentioning

confidence: 99%

Interventional radiology of the thyroid gland: critical review and state of the art

et al. 2018

View full text Add to dashboard Cite

Thyroid nodules are a common incidental finding during a routinely ultrasound (US) exam unrelated to the thyroid gland in the healthy adult population with a prevalence of 20-76%. As treated before with surgery, in the last years new minimally invasive techniques have been developed as an alternative to surgery. The aim of this review, based on newly revised guidelines, is to provide some information regarding the basic principles, indications, materials, techniques, and results of mini-invasive procedures or treatments for thyroid nodules. We performed a narrative review including both newest and representative papers and guidelines based on the different procedures of ablation techniques developed in the last years for the diagnosis and the treatment of thyroid nodules. All examined papers referred very good results in term of volume nodule reduction, improvement in related symptoms and cosmetic problems, with a very low rate of complications and side effects for all the minimally invasive technique analyzed. Obviously, some differents between technique based on different kind of thyroid nodules and different indication were found. In conclusion, many thyroid nodules nowadays could be treated thanks to the advent of new mini-invasive technique that are less expensive and present a lower risk of major complications and side effects compared to surgery.

show abstract

Ethanol and thermal ablation for malignant thyroid tumours

Cited by 30 publications

References 68 publications

Thyroid nodules ≤ 1 cm and papillary thyroid microcarcinomas: Brazilian experts opinion

Thyroid nodules ≤ 1 cm and papillary thyroid microcarcinomas: Brazilian experts opinion

Ultrasound-guided radiofrequency ablation for papillary thyroid microcarcinoma: a retrospective analysis of 198 patients

Interventional radiology of the thyroid gland: critical review and state of the art

Contact Info

Product

Resources

About