Ethanol consumption synergistically increases ultraviolet radiation induced skin damage and immune dysfunction

Brand, Rhonda M.; Stottlemyer, J. Mark; Paglia, Melissa; Carey, Cara Donahue; Falo, Louis D.

doi:10.1016/j.jdermsci.2020.11.001

Cited by 7 publications

(6 citation statements)

References 49 publications

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“…According to an Irish research study, 74% of school-age children (10-17 years) experienced sunburn in 2017, with 10% reporting ≥5 sunburns [18]. Ultraviolet radiation exposure is an important risk factor for skin inflammation and skin cancer, while ultraviolet overexposure and a history of associated solar dermatitis are important risk factors for skin cancer [19]. That is why the number of hospital outpatient emergency room visits to treat sunburns has increased as knowledge about the subject has become more widespread.…”

Section: Discussionmentioning

confidence: 99%

Liquiritin Carbomer Gel Cold Paste Promotes Healing of Solar Dermatitis in Mice

Huang,

Li,

Pan

et al. 2024

IJMS

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Ultraviolet radiation (UVR) has various effects on human cells and tissues, which can lead to a variety of skin diseases and cause inconvenience to people’s lives. Among them, solar dermatitis is one of the important risk factors for malignant melanoma, so prevention and treatment of solar dermatitis is very necessary. Additionally, liquiritin (LQ) has anti-inflammatory effects. In this study, we aimed to evaluate the anti-inflammatory and pro-wound healing effects of liquiritin carbomer gel cold paste (LQ-CG-CP) in vitro and in vivo. The results of MTT experiments showed no cytotoxicity of LQ at concentrations of 40 μg/mL and below and cell damage at UVB irradiation doses above 60 mJ/cm2. Moreover, LQ can promote cell migration. ELISA results also showed that LQ inhibited the elevation of the inflammatory factors tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6) after UVB irradiation. In the mouse model of solar dermatitis, 2% LQ-CG-CP showed the best therapeutic efficacy for wound healing and relief of itching compared to MEIBAO moist burn moisturizer (MEBO). What is more, the results of skin histopathological examination show that LQ-CG-CP promotes re-epithelialization, shrinks wounds, and promotes collagen production, thus promoting wound healing. Simultaneously, LQ-CG-CP reduced TNF-α, IL-1β, and IL-6 expression. In addition, LQ-CG-CP was not observed to cause histopathological changes and blood biochemical abnormalities in mice. Overall, LQ-CG-CP has great potential for the treatment of solar dermatitis.

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Section: Discussionmentioning

confidence: 99%

Liquiritin Carbomer Gel Cold Paste Promotes Healing of Solar Dermatitis in Mice

Huang,

Li,

Pan

et al. 2024

IJMS

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“…A possible synergistic effect of simultaneous exposure to UV radiation and excessive alcohol consumption on sunburn and skin damage has previously been raised in epidemiological studies (reviewed in [ 47 ]). New work in mouse models and using human skin explants suggests that this is not due to alcohol-induced risky sun exposure behaviour, but rather that synergistic metabolic pathways induce more DNA mutations and immune dysfunction [ 47 ].…”

Section: Harms Of Exposure To Uv Radiationmentioning

confidence: 99%

The effects of exposure to solar radiation on human health

Neale

Lucas

Byrne

et al. 2023

Photochem Photobiol Sci

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This assessment by the Environmental Effects Assessment Panel (EEAP) of the Montreal Protocol under the United Nations Environment Programme (UNEP) evaluates the effects of ultraviolet (UV) radiation on human health within the context of the Montreal Protocol and its Amendments. We assess work published since our last comprehensive assessment in 2018. Over the last four years gains have been made in knowledge of the links between sun exposure and health outcomes, mechanisms, and estimates of disease burden, including economic impacts. Of particular note, there is new information about the way in which exposure to UV radiation modulates the immune system, causing both harms and benefits for health. The burden of skin cancer remains high, with many lives lost to melanoma and many more people treated for keratinocyte cancer, but it has been estimated that the Montreal Protocol will prevent 11 million cases of melanoma and 432 million cases of keratinocyte cancer that would otherwise have occurred in the United States in people born between 1890 and 2100. While the incidence of skin cancer continues to rise, rates have stabilised in younger populations in some countries. Mortality has also plateaued, partly due to the use of systemic therapies for advanced disease. However, these therapies are very expensive, contributing to the extremely high economic burden of skin cancer, and emphasising the importance and comparative cost-effectiveness of prevention. Photodermatoses, inflammatory skin conditions induced by exposure to UV radiation, can have a marked detrimental impact on the quality of life of sufferers. More information is emerging about their potential link with commonly used drugs, particularly anti-hypertensives. The eyes are also harmed by over-exposure to UV radiation. The incidence of cataract and pterygium is continuing to rise, and there is now evidence of a link between intraocular melanoma and sun exposure. It has been estimated that the Montreal Protocol will prevent 63 million cases of cataract that would otherwise have occurred in the United States in people born between 1890 and 2100. Despite the clearly established harms, exposure to UV radiation also has benefits for human health. While the best recognised benefit is production of vitamin D, beneficial effects mediated by factors other than vitamin D are emerging. For both sun exposure and vitamin D, there is increasingly convincing evidence of a positive role in diseases related to immune function, including both autoimmune diseases and infection. With its influence on the intensity of UV radiation and global warming, the Montreal Protocol has, and will have, both direct and indirect effects on human health, potentially changing the balance of the risks and benefits of spending time outdoors. Graphical abstract

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“…To elucidate the synergistic effects of ethanol and UV exposure on skin cells, Brand et al used mouse models and human skin explants [ 153 ]. They demonstrated that combined ethanol consumption and UV exposure increased immune dysfunction and skin damage by decreasing DNA repair capacity and inhibiting protective mechanisms such as melanin production and anti-oxidants against UV exposure.…”

Section: Potential Roles Of Ethanol On Melanoma Initiation and Progre...mentioning

confidence: 99%

Alcohol as a Non-UV Social-Environmental Risk Factor for Melanoma

Yamauchi

Shangraw²,

Zhai³

et al. 2022

Cancers

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Although cancer mortality has declined among the general population, the incidence of melanoma continues to rise. While identifying high-risk cohorts with genetic risk factors improves public health initiatives and clinical care management, recognizing modifiable risk factors such as social-environmental risk factors would also affect the methods of patient outreach and education. One major modifiable social-environmental risk factor associated with melanoma is ultraviolet (UV) radiation. However, not all forms of melanoma are correlated with sun exposure or occur in sun-exposed areas. Additionally, UV exposure is rarely associated with tumor progression. Another social-environmental factor, pregnancy, does not explain the sharply increased incidence of melanoma. Recent studies have demonstrated that alcohol consumption is positively linked with an increased risk of cancers, including melanoma. This perspective review paper summarizes epidemiological data correlating melanoma incidence with alcohol consumption, describes the biochemical mechanisms of ethanol metabolism, and discusses how ethanol and ethanol metabolites contribute to human cancer, including melanoma.

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Ethanol consumption synergistically increases ultraviolet radiation induced skin damage and immune dysfunction

Cited by 7 publications

References 49 publications

Liquiritin Carbomer Gel Cold Paste Promotes Healing of Solar Dermatitis in Mice

Liquiritin Carbomer Gel Cold Paste Promotes Healing of Solar Dermatitis in Mice

The effects of exposure to solar radiation on human health

Alcohol as a Non-UV Social-Environmental Risk Factor for Melanoma

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