Ethanol extract of Bergenia ciliata (Haw.) Sternb. (rhizome) impedes the propagation of the malaria parasite

Chemistry and Pharmacology of Bergenin or Its Derivatives: A Promising Molecule

“…Singh et al [ 39 ] experimentally induced P. berghei infection intraperitoneally in mice and, after 7 days of infection, treated with bergenin (isolated from F. virosa leaves) at concentrations of 25 to 100 mg/kg for 8 days, it caused an 85.13% suppression of parasitemia on the eighth day at a concentration of 100 mg/kg bergenin. These results are similar to the findings of Gorky et al [ 15 ].…”

“…The crude extract presented an IC 50 of 2.35 µg/mL for 3D7 and 4.73 µg/mL for K1, while the fractions presented an IC 50 of 1.73 to 8.61 µg/mL for 3D7 and 2.32 to 20 µg/mL for K1 against 5.5 and 2.54 nM of the positive control (chloroquine), respectively [ 39 ]. Other studies with the same approach, using extracts with bergenin as one of the constituents, had satisfactory results in vitro: ethanolic and methanolic extract of stems and leaves of H. balsamifera against a culture of BHz 26/28 of P. falciparum resistant to chloroquine, IC 50 ranging from 8.37 to 49.65 µg/mL [ 13 ]; ethanolic extract of the rhizome of W. bignonia against strains of P. falciparum RKL-9 2, IC 50 of 5 µg/mL [ 15 ]; ethanolic extract of B. ciliata rhizome against P. falciparum strains RKL-9 and MRC-2, IC 50 of 5 µg/mL [ 15 ]; methanolic extract of D. Sanza-Minika stem bark against P. falciparum K1, IC 50 of 0.6 µg/mL [ 36 ].…”

Bridging Tradition and Modern Pharmacology of Bergenia ciliata (Haw.) Sternb: A Review

“…Among the diverse solvents and plant parts utilized for extract preparation, methanol extract from the rhizome emerged as the most effective in controlling these pathogenic bacteria 4,66 . The plant was also found to be effective in supressing the malarial parasites -Plasmodium falciparum and P. berghei 68,69 . Leaf extract exhibited considerable antimalarial activity against P. falciparum 70 .…”

“…Recent in vivo studies of the ethanol extract of rhizome exhibited considerable inhibition of schizont maturation of two strains of P. falciparum 69 . The efficacy of the rhizome extract was found to be comparatively higher than the chloroquine.…”