Ethanol extract of Caesalpinia bonduc (L.) Roxb root improves the sexual performance of male Wistar rats

Sindete, Mariette; Gbankoto, Adam; Ganfon, Habib; Yemoa, Achille; Dramane, K.; Laleye, Anatole

doi:10.5455/ijmsph.2020.1030702122019

Cited by 2 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our previous studies showed the presence of flavonoids, alkaloids, tannins, saponins, free anthracenics, quinoid derivatives, phenolics, coumarins, anthocyans, leucoanthocyans, triterpenoids, steroids, and mucilages in CB root [ 20 , 22 ]. Studies confirmed that herbal extracts, a mixture of Scutellariae radix and Platycodi radix, containing the active ingredients baicalin and saponin were able to decrease body weight in rats [ 44 ].…”

Section: Discussionmentioning

confidence: 99%

“…Isolated flavonoids from young twigs and leaves of CB have been reported to exhibit anticancer activity and high antioxidant capacity [ 19 ]. Researchers have reported the aphrodisiac property of aqueous and ethanolic extract of CB root as well as the acute and subacute (28 days) oral toxicity of ethanolic extract of CB root [ 20 – 22 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A 90-Day Oral Toxicity Study of an Ethanolic Root Extract of Caesalpinia bonduc (L.) Roxb. in Wistar Rats

Sindete

Gbankoto

Osseni

et al. 2021

Evidence-Based Complementary and Alternative Medicine

Self Cite

View full text Add to dashboard Cite

Background. Plant medicine is the oldest form of health care known to mankind; hence, studies on their safety for use are essential for the control of adverse drug effects. In Benin, Caesalpinia bonduc is one of many medicinal plants used as aphrodisiac, and for treatment of various ailments including prostatic hyperplasia. Despite its numerous ethnomedicinal benefits, toxicological information associated with its chronic use is currently limited. Objective. The present study therefore assessed the toxicity of an ethanolic root extract of Caesalpinia bonduc in Wistar rats. Methods. Caesalpinia bonduc root extract was administered by oral gavage at doses of 31.25, 125, and 500 mg/kg/day for 90 days to male Wistar rats, after which body weight changes, food consumption, urinary parameters, hematological and blood biochemical parameters, organ weights changes, gross pathology, and histopathology of vital organs were assessed. Results. There were no death or abnormal clinical signs, no significant changes in body weight gain or urinary parameters, and no changes in necropsy and histopathology findings of vital organs associated with extract treatment. However, some indices such as erythrocytes, total cholesterol, and aspartate amino transferase increased in rats treated with high doses of the extract, as well as relative weight of testes, followed by a decrease in food intake and prostate relative weight. Conclusion. The results indicate that an ethanolic root extract of Caesalpinia bonduc does not cause significant adverse effects and suggest its tolerability up to 500 mg/kg for daily administration of 90 days.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A 90-Day Oral Toxicity Study of an Ethanolic Root Extract of Caesalpinia bonduc (L.) Roxb. in Wistar Rats

Sindete

Gbankoto

Osseni

et al. 2021

Evidence-Based Complementary and Alternative Medicine

Self Cite

View full text Add to dashboard Cite

show abstract

Unleashing the Potential of Medicinal Plants in Benin: Assessing the Status of Research and the Need for Enhanced Practices

Agbodjento

Lègba

Dougnon

et al. 2023

Plants

View full text Add to dashboard Cite

Medicinal plants play a crucial role in the primary health care of the population in developing countries such as Benin. The national universities of Benin conduct research on the pharmacological, toxicological, and phytochemical properties of these plants, but the resulting knowledge often does not lead to the development of phytomedicines for the improvement of public health. This study aims to assess the current status of research on medicinal plants in Benin. A literature review was conducted using various search engines, and the collected data was analyzed. The results indicate that research on the biological properties of medicinal plants is still in its early stages, with limited and inadequate methodological approaches. These limitations highlight the urgent need to enhance research practices and facilitate the development of effective and safe phytomedicines.

show abstract

Ethanol extract of Caesalpinia bonduc (L.) Roxb root improves the sexual performance of male Wistar rats

Cited by 2 publications

References 0 publications

A 90-Day Oral Toxicity Study of an Ethanolic Root Extract of Caesalpinia bonduc (L.) Roxb. in Wistar Rats

A 90-Day Oral Toxicity Study of an Ethanolic Root Extract of Caesalpinia bonduc (L.) Roxb. in Wistar Rats

Unleashing the Potential of Medicinal Plants in Benin: Assessing the Status of Research and the Need for Enhanced Practices

Contact Info

Product

Resources

About