Ethanol extract of Centella asiatica alleviated dextran sulfate sodium-induced colitis: Restoration on mucosa barrier and gut microbiota homeostasis

Li, Huibiao; Chen, Xiaohong; Liu, Jiayao; Chen, Muyuan; Huang, Ming; Huang, Guoxin; Chen, Xinlin; Du, Qingyou; Su, Juanjuan; Lin, Rong-Feng

doi:10.1016/j.jep.2020.113445

Cited by 45 publications

(29 citation statements)

References 46 publications

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“…For example, Helicobacter , a potentially virulent pathogen, was rich in the model group but reduced its quantity in the GA-H group in this study. It could disrupt the intestinal barrier and intestinal microbes, promoting the development of intestinal inflammation [ 28 ]. In addition, the data show that GA-H treatment greatly increases the relative abundance of Lactobacillus , Caldicoprobacter , and Bifidobacterium .…”

Section: Discussionmentioning

confidence: 99%

The Protective Effects of Ganoderic Acids from Ganoderma lucidum Fruiting Body on Alcoholic Liver Injury and Intestinal Microflora Disturbance in Mice with Excessive Alcohol Intake

Cao

Huang

You

et al. 2022

Foods

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This study aimed to investigate the protective effects of ganoderic acids (GA) from Ganoderma lucidum against liver injury and intestinal microbial disorder in mice with excessive alcohol intake. Results showed GA supplement significantly inhibited the abnormal elevation of the liver index, serum lipid parameters, aspartate aminotransferase and alanine aminotransferase in mice exposed to alcohol intake, and also significantly protected the excessive lipid accumulation and pathological changes. Alcohol-induced oxidative stress in the liver was significantly ameliorated by GA intervention through reducing the levels of maleic dialdehyde and lactate dehydrogenase and increasing the levels of glutathione, catalase, superoxide dismutase and alcohol dehydrogenase. Intestinal microbiota profiling demonstrated GA intervention modulated the composition of intestinal microflora by increasing the levels of Lactobacillus, Faecalibaculum, Romboutsia, Bifidobacterium and decreasing the Helicobacter level. Furthermore, liver metabolomic profiling suggested GA intervention had a remarkable regulatory effect on liver metabolism with excessive alcohol consumption. Moreover, GA intervention regulated mRNA levels of alcohol metabolism, fatty lipid metabolism, oxidative stress, bile acid biosynthesis and metabolism-related genes in the liver. Conclusively, these findings demonstrate GA intervention can significantly relieve alcoholic liver injury and it is hopeful to become a new functional food ingredient for the prevention of alcoholic liver injury.

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Section: Discussionmentioning

confidence: 99%

The Protective Effects of Ganoderic Acids from Ganoderma lucidum Fruiting Body on Alcoholic Liver Injury and Intestinal Microflora Disturbance in Mice with Excessive Alcohol Intake

Cao

Huang

You

et al. 2022

Foods

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“…The aerial parts of Centella asiatica (L.) Urban, a herbal brain tonic for mental disorders [ 80 ], significantly reduced stress-related depression and anxiety [ 81 ]. C. asiatica is rich in triterpenoids, specifically asiaticoside, and has shown gut microbiota-modulating properties in a murine colitis model [ 82 ].…”

Section: Resultsmentioning

confidence: 99%

“…Taken together, as shown in Figure 3 , the available data suggest that triterpenes may modulate an imbalanced microbiome–gut–brain communication during impaired brain functions and promote mental health [ 207 , 209 , 210 , 211 , 212 , 213 ]. G. pentaphyllum , C. asiatica , and P. ginseng exerted prebiotic-like effects and led to a recovered intestinal flora diversity or mitigated gut dysbiosis compared with control groups in rodent models [ 82 , 115 , 116 , 120 , 142 , 144 , 149 ].…”

Section: Resultsmentioning

confidence: 99%

Medicinal Plants and Their Impact on the Gut Microbiome in Mental Health: A Systematic Review

et al. 2022

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Background: Various neurocognitive and mental health-related conditions have been associated with the gut microbiome, implicating a microbiome–gut–brain axis (MGBA). The aim of this systematic review was to identify, categorize, and review clinical evidence supporting medicinal plants for the treatment of mental disorders and studies on their interactions with the gut microbiota. Methods: This review included medicinal plants for which clinical studies on depression, sleeping disorders, anxiety, or cognitive dysfunction as well as scientific evidence of interaction with the gut microbiome were available. The studies were reported using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Results: Eighty-five studies met the inclusion criteria and covered thirty mental health-related medicinal plants with data on interaction with the gut microbiome. Conclusion: Only a few studies have been specifically designed to assess how herbal preparations affect MGBA-related targets or pathways. However, many studies provide hints of a possible interaction with the MGBA, such as an increased abundance of health-beneficial microorganisms, anti-inflammatory effects, or MGBA-related pathway effects by gut microbial metabolites. Data for Panax ginseng, Schisandra chinensis, and Salvia rosmarinus indicate that the interaction of their constituents with the gut microbiota could mediate mental health benefits. Studies specifically assessing the effects on MGBA-related pathways are still required for most medicinal plants.

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“…Given the potential risk of administering conventional medications, such as antibiotics, TCM has attracted increasing interest for many disease treatments, such as diabetes ( 153 ), ulcerative colitis (UC) ( 154 ) and kidney diseases ( 155 ), the mechanisms of which have been further demonstrated to be associated with the intestinal microbiota. The treatment of diabetes mellitus is one of the most typical examples showing that TCM’s regulatory effect on the intestinal flora exerts a therapeutic role ( 153 , 156 ).…”

Section: Commonly Used Methods To Regulate the Microbiotamentioning

confidence: 99%

“…The same mechanisms were also found during the treatment of antibiotic-associated diarrhoea (AAD) with Xianglian pill (XLP), a traditional Chinese pharmaceutical preparation synthesized from BBR as a raw material ( 157 ). Centella asiatica (CA) is a traditional medicinal herb with a long history of anti-inflammatory application that was demonstrated to reshape the gut microbiota in UC mice by increasing the α-diversity and shifting the community by depleting colitis-associated genera to repair the intestinal mucosal barrier ( 154 ). The Baitouweng (BTW) decoction also improved inflammatory symptoms in mice with UC by modulating the intestinal microflora, including decreasing the proportion of Firmicutes to Bacteroidetes and the ratio of Proteobacteria , decreasing the relative abundance of Escherichia-Shigella and increasing the relative abundance of Lactobacillus and Akkermansia ( 158 ).…”

Section: Commonly Used Methods To Regulate the Microbiotamentioning

confidence: 99%

Intestinal Microbiota—A Promising Target for Antiviral Therapy?

Yang

et al. 2021

Front. Immunol.

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The intestinal microbiota is thought to be an important biological barrier against enteric pathogens. Its depletion, however, also has curative effects against some viral infections, suggesting that different components of the intestinal microbiota can play both promoting and inhibitory roles depending on the type of viral infection. The two primary mechanisms by which the microbiota facilitates or inhibits viral invasion involve participation in the innate and adaptive immune responses and direct or indirect interaction with the virus, during which the abundance and composition of the intestinal microbiota might be changed by the virus. Oral administration of probiotics, faecal microbiota transplantation (FMT), and antibiotics are major therapeutic strategies for regulating intestinal microbiota balance. However, these three methods have shown limited curative effects in clinical trials. Therefore, the intestinal microbiota might represent a new and promising supplementary antiviral therapeutic target, and more efficient and safer methods for regulating the microbiota require deeper investigation. This review summarizes the latest research on the relationship among the intestinal microbiota, anti-viral immunity and viruses and the most commonly used methods for regulating the intestinal microbiota with the goal of providing new insight into the antiviral effects of the gut microbiota.

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Ethanol extract of Centella asiatica alleviated dextran sulfate sodium-induced colitis: Restoration on mucosa barrier and gut microbiota homeostasis

Cited by 45 publications

References 46 publications

The Protective Effects of Ganoderic Acids from Ganoderma lucidum Fruiting Body on Alcoholic Liver Injury and Intestinal Microflora Disturbance in Mice with Excessive Alcohol Intake

The Protective Effects of Ganoderic Acids from Ganoderma lucidum Fruiting Body on Alcoholic Liver Injury and Intestinal Microflora Disturbance in Mice with Excessive Alcohol Intake

Medicinal Plants and Their Impact on the Gut Microbiome in Mental Health: A Systematic Review

Intestinal Microbiota—A Promising Target for Antiviral Therapy?

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